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Identification of Novel Functionally Important Aromatic Residue Interactions in the Extracellular Domain of the Glycine Receptor.
Expression of functional inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 by astrocytes of inferior colliculus and hippocampus.
Elsa Ghirardini, Simon L Wadle, Vanessa Augustin, Jasmin Becker, Sina Brill, Julia Hammerich, Gerald Seifert, Jonathan Stephan
Jun 25, 2018
Neuronal inhibition is mediated by glycine and/or GABA. Inferior colliculus (IC) neurons receive glycinergic and GABAergic inputs, whereas inhibition in hippocampus (HC) predominantly relies on GABA. Astrocytes heterogeneously...
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
Erik Volz, Verity Hill, John T McCrone, Anna Price, David Jorgensen, Áine O'Toole, Joel Southgate, Robert Johnson, Ben Jackson, Fabricia F Nascimento, Sara M Rey, Samuel M Nicholls, Rachel M Colquhoun, Ana da Silva Filipe, James Shepherd, David J Pascall, Rajiv Shah, Natasha Jesudason, Kathy Li, Ruth Jarrett, Nicole Pacchiarini, Matthew Bull, Lily Geidelberg, Igor Siveroni, COG-UK Consortium, Ian Goodfellow, Nicholas J Loman, Oliver G Pybus, David L Robertson, Emma C Thomson, Andrew Rambaut, Thomas R Connor
Jan 12, 2021
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection...
Proline provides site-specific flexibility for in vivo collagen.
Wing Ying Chow, Chris J Forman, Dominique Bihan, Anna M Puszkarska, Rakesh Rajan, David G Reid, David A Slatter, Lucy J Colwell, David J Wales, Richard W Farndale, Melinda J Duer
Sep 08, 2018
Enhancing the mechanical properties of natural jute yarn suitable for structural applications
Abstract
Manufacturing natural-based high-performance composites are becoming of greater interest to the composite manufacturers and to their end-users due to their...
A cross-platform approach identifies genetic regulators of human metabolism and health.
Luca A Lotta, Maik Pietzner, Isobel D Stewart, Laura BL Wittemans, Chen Li, Roberto Bonelli, Johannes Raffler, Emma K Biggs, Clare Oliver-Williams, Victoria PW Auyeung, Jian'an Luan, Eleanor Wheeler, Ellie Paige, Praveen Surendran, Gregory A Michelotti, Robert A Scott, Stephen Burgess, Verena Zuber, Eleanor Sanderson, Albert Koulman, Fumiaki Imamura, Nita G Forouhi, Kay-Tee Khaw, MacTel Consortium, Julian L Griffin, Angela M Wood, Gabi Kastenmüller, John Danesh, Adam S Butterworth, Fiona M Gribble, Frank Reimann, Melanie Bahlo, Eric Fauman, Nicholas J Wareham, Claudia Langenberg
Jan 12, 2021
In cross-platform analyses of 174 metabolites, we identify 499 associations (P < 4.9 × 10-10) characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and enrichment for nonsynonymous variation. We...
Diabetes mellitus Type 2 Eye Diseases Gene Frequency Genetic Loci Genetic Pleiotropy Genome Human Glucagon-Like Peptide-2 Receptor Glycine HEALTH Humans Linear Models Mendelian Randomization Analysis metabolism metabolism Inborn Errors Metabolome Mutation Missense Phenotype Polymorphism Single Nucleotide Retinal Telangiectasis Sample Size Serine
Assessing the causal association of glycine with risk of cardio-metabolic diseases.
Laura BL Wittemans, Luca A Lotta, Clare Oliver-Williams, Isobel D Stewart, Praveen Surendran, Savita Karthikeyan, Felix R Day, Albert Koulman, Fumiaki Imamura, Lingyao Zeng, Jeanette Erdmann, Heribert Schunkert, Kay-Tee Khaw, Julian L Griffin, Nita G Forouhi, Robert A Scott, Angela M Wood, Stephen Burgess, Joanna MM Howson, John Danesh, Nicholas J Wareham, Adam S Butterworth, Claudia Langenberg
Feb 18, 2019
Astroglial D-serine is the endogenous co-agonist at the presynaptic NMDA receptor in rat entorhinal cortex
Presynaptic NMDA receptors facilitate the release of glutamate at excitatory cortical synapses and are involved in regulation of synaptic dynamics and plasticity. At synapses in the entorhinal cortex these receptors are...
Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene
Hisham Ziauddeen, Liam J Nestor, Naresh Subramaniam, Chris Dodds, Pradeep J Nathan, Sam R Miller, Bhopinder K Sarai, Kay Maltby, Disala Fernando, Liling Warren, Louise K Hosking, Dawn Waterworth, Anna Korzeniowska, Beta Win, Duncan B Richards, Lakshmi Vasist Johnson, Paul C Fletcher, Edward T Bullmore
Apr 22, 2016
Astroglial D-serine is the endogenous co-agonist at the presynaptic NMDA receptor in rat entorhinal cortex
Presynaptic NMDA receptors facilitate the release of glutamate at excitatory cortical synapses and are involved in regulation of synaptic dynamics and plasticity. At synapses in the entorhinal cortex these receptors are...
Serine Is an Essential Metabolite for Effector T Cell Expansion.
Eric H Ma, Glenn Bantug, Takla Griss, Stephanie Condotta, Radia M Johnson, Bozena Samborska, Nello Mainolfi, Vipin Suri, Hannah Guak, Maria L Balmer, Mark J Verway, Thomas C Raissi, Harmony Tsui, Giselle Boukhaled, Sofia Henriques da Costa, Christian Frezza, Connie M Krawczyk, Adam Friedman, Mark Manfredi, Martin J Richer, Christoph Hess, Russell G Jones
Jan 12, 2018
During immune challenge, T lymphocytes engage pathways of anabolic metabolism to support clonal expansion and the development of effector functions. Here we report a critical role for the non-essential amino acid serine in...
Phgdh Shmt T cell Glycolysis immunometabolism Immunotherapy Metabolic reprogramming metabolism Serine serine biosynthesis Animals Carbon Cell Cycle Checkpoints Cell Proliferation Diet Energy Metabolism Extracellular Space Glycine Listeria monocytogenes Metabolic Networks and Pathways Metabolome Mice Inbred C57BL Purine Nucleotides Serine T-Lymphocytes
Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages
Milos Gojkovic, Pedro P Cunha, Gabriella S Darmasaputra, Laura Barbieri, Helene Rundqvist, Pedro Veliça, Randall S Johnson
Jun 10, 2021
Myeloid cell interactions with cells of the adaptive immune system are an essential aspect of immunity. A key aspect of that interrelationship is its modulation by the microenvironment. Oxygen is known to influence...
HIF Nitric oxide prolyl hydroxylase inhibitors Hypoxia immunosuppression Myeloid Cells von Hippel-Lindau. Adaptive Immunity Animals CD8-Positive T-Lymphocytes Cell Hypoxia Cell Line Tumor Cell Proliferation Coculture Techniques Glycine Humans Hypoxia-Inducible Factor 1 alpha Subunit Isoquinolines MACROPHAGES Mice Mice Transgenic Oxygen Von Hippel-Lindau Tumor Suppressor Protein
Enhancing the mechanical properties of natural jute yarn suitable for structural applications
Md. Ashadujjaman, Abu Saifullah, Darshill U Shah, Minglonghai Zhang, Mahmudul Akonda, Nazmul Karim, Forkan Sarker
May 12, 2021
Abstract: Manufacturing natural-based high-performance composites are becoming of greater interest to the composite manufacturers and to their end-users due to their bio-degradability, low cost and availability. Yarn based...
Single-site glycine-specific labeling of proteins.
Landa Purushottam, Srinivasa Rao Adusumalli, Usha Singh, VB Unnikrishnan, Dattatraya Gautam Rawale, Mansi Gujrati, Ram Kumar Mishra, Vishal Rai
Jan 25, 2021
Labeling of native proteins invites interest from diverse segments of science. However, there remains the significant unmet challenge in precise labeling at a single site of a protein. Here, we report the site-specific labeling...
Diversity in kinetics correlated with structure in nano body-stabilized LacY.
Hemant Kumar, Janet Finer-Moore, Irina Smirnova, Vladimir Kasho, Els Pardon, Jan Steyaert, H Ronald Kaback, Robert M Stroud
May 07, 2020
Amino Acid Substitution Antigen-Antibody Reactions Binding Sites Crystallography X-Ray Escherichia coli Proteins Galactose Glycine Hydrogen Bonding Kinetics Models Molecular Monosaccharide Transport Proteins Mutation Missense Point Mutation Protein Binding Protein Conformation Protein Stability Single-Domain Antibodies Structure-Activity Relationship Symporters Thiogalactosides Tryptophan
Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa.
Douglas J Fraser-Pitt, Stephen K Dolan, David Toledo-Aparicio, Jessica G Hunt, Daniel W Smith, Niamh Lacy-Roberts, Piumi Sara Nupe Hewage, Teodora N Stoyanova, Erin Manson, Kevin McClean, Neil F Inglis, Derry K Mercer, Deborah A O'Neil
Oct 06, 2021
Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that...
Enhancing the mechanical properties of natural jute yarn suitable for structural applications
Md. Ashadujjaman, Abu Saifullah, Darshill U Shah, Minglonghai Zhang, Mahmudul Akonda, Nazmul Karim, Forkan Sarker
May 12, 2021
Abstract: Manufacturing natural-based high-performance composites are becoming of greater interest to the composite manufacturers and to their end-users due to their bio-degradability, low cost and availability. Yarn based...
Exploiting tumour addiction with a serine and glycine-free diet.
Understanding cancer metabolism is key to unveil the Achilles’ heel of cancer cells and provide novel therapeutic interventions for patients. While the rerouting of metabolic pathways during development1 or cancer transformation...