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Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.
Anna L Godfrey, Peter J Campbell, Cathy MacLean, Georgina Buck, Julia Cook, Julie Temple, Bridget S Wilkins, Keith Wheatley, Jyoti Nangalia, Jacob Grinfeld, Mary Frances McMullin, Cecily Forsyth, Jean-Jacques Kiladjian, Anthony R Green, Claire N Harrison, United Kingdom Medical Research Council Primary Thrombocythemia-1 Study, United Kingdom National Cancer Research Institute Myeloproliferative Neoplasms Subgroup, French Intergroup of Myeloproliferative Neoplasms, the Australasian Leukaemia and Lymphoma Group.
Sep 29, 2018
Adult Aspirin Australia Disease Progression Dose-Response Relationship Drug Drug Administration Schedule Drug Therapy Combination Female France Humans Hydroxyurea Internationality Ireland Janus Kinase 2 Kaplan-Meier Estimate Male Middle Aged New Zealand Prognosis Proportional Hazards Models Prospective Studies Risk Assessment Severity of Illness Index Thrombocythemia Essential Thrombosis Treatment Outcome United Kingdom
Resolving $\textit{TYK2}$ locus genotype-to-phenotype differences in autoimmunity
CA Dendrou, A Cortes, L Shipman, HG Evans, KE Attfield, L Jostins, T Barber, G Kaur, SB Kuttikkatte, OA Leach, C Desel, SL Faergeman, J Cheeseman, MJ Neville, S Sawcer, A Compston, AR Johnson, C Everett, JI Bell, F Karpe, M Ultsch, C Eigenbrot, G McVean, L Fugger
Feb 23, 2017
Animals Autoimmune Diseases Autoimmunity CD4-Positive T-Lymphocytes Cytokines Epigenesis Genetic Female Genetic Association Studies genetic variation Genomics Genotype HEK293 Cells Homozygote Humans Immune System Janus Kinase 2 Leukocytes Mononuclear Male Mice Mutation Missense Phenotype Polymorphism Single Nucleotide Protein Conformation Quantitative Trait Loci Recombination Genetic Sequence Analysis RNA Signal Transduction TYK2 Kinase Transcriptome
The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms
Beatrice Drexler, Jakob R Passweg, Alexandar Tzankov, Martin Bigler, Alexandre Pa Theocharides, Nathan Cantoni, Peter Keller, Georg Stussi, Axel Ruefer, Rudolf Benz, Geneviève Favre, Pontus Lundberg, Ronny Nienhold, Andrea Fuhrer, Christine Biaggi, Markus G Manz, Mario Bargetzi, Simon Mendez-Ferrer, Radek C Skoda, Swiss Group for Clinical Cancer Research (SAKK)
Dec 13, 2018
The β-3 sympathomimetic agonist BRL37344 restored nestin-positive cells within the stem cell niche, and thereby normalized blood counts and improved myelofibrosis in a mouse model of JAK2-V617F-positive myeloproliferative...
High prevalence of heparin induced thrombocytopenia with thrombosis among patients with essential thrombocytemia carrying V617F mutation.
Roberto Castelli, Paolo Gallipoli, Riccardo Schiavon, Thomas Teatini, Giorgio Lambertenghi Deliliers, Luigi Bergamaschini
Dec 12, 2018
Arterial and venous complications are major causes of morbidity and mortality in myeloproliferative neoplasms (MPNs). MPNs patients, frequently receive heparin. Heparin-induced thrombocytopenia (HIT) is a rare but potentially...
Essential thrombocythemia Heparin treatment Heparin-induced thrombocytopenia (HIT) Myeloproliferative neoplasms (MPNs) V617F mutation Adult Aged Antibodies Female Heparin Humans Janus Kinase 2 Male Middle Aged Mutation Missense Platelet Count prevalence Retrospective Studies Thrombocythemia Essential Thrombocytopenia Thrombosis
BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms.
BS Wyspiańska, AJ Bannister, I Barbieri, J Nangalia, A Godfrey, FJ Calero-Nieto, S Robson, I Rioja, J Li, M Wiese, E Cannizzaro, MA Dawson, B Huntly, RK Prinjha, AR Green, B Gottgens, T Kouzarides
Jun 13, 2014
MARIMO cells harbor a CALR mutation but are not dependent on JAK2/STAT5 signaling.
K Kollmann, J Nangalia, W Warsch, H Quentmeier, A Bench, E Boyd, M Scott, HG Drexler, AR Green
Dec 18, 2014
Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms.
Jingyuan Tong, Ting Sun, Shihui Ma, Yanhong Zhao, Mankai Ju, Yuchen Gao, Ping Zhu, Puwen Tan, Rongfeng Fu, Anqi Zhang, Ding Wang, Di Wang, Zhijian Xiao, Jiaxi Zhou, Renchi Yang, Stephen J Loughran, Juan Li, Anthony R Green, Emery H Bresnick, Dong Wang, Tao Cheng, Lei Zhang, Lihong Shi
Feb 24, 2021
The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F+ myeloproliferative neoplasms (MPNs), harboring the same mutation in hematopoietic stem cells (HSCs), display diverse...
Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma.
Justyna A Kucia-Tran, Valtteri Tulkki, Cinzia G Scarpini, Stephen Smith, Maja Wallberg, Marta Paez-Ribes, Angela M Araujo, Jan Botthoff, Maria Feeney, Katherine Hughes, Maria M Caffarel, Nicholas Coleman
Feb 13, 2018
The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the...
STAT3 cervix head and neck metastasis neutralizing antibodies oncostatin M receptor squamous cell carcinoma Animals Antineoplastic Agents Immunological Autocrine Communication Cell Line Tumor Female Gene Expression Regulation Neoplastic Head and Neck Neoplasms Humans Janus Kinase 2 Lung Neoplasms Mice Inbred NOD Mice SCID Oncostatin M Oncostatin M Receptor beta Subunit Phosphorylation STAT3 Transcription Factor Signal Transduction Squamous Cell Carcinoma of Head and Neck Suppressor of Cytokine Signaling 3 Protein Up-Regulation Uterine Cervical Neoplasms Xenograft Model Antitumor Assays
Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines.
James R Matthews, Susan MR Watson, Maxine CL Tevendale, Christine J Watson, Alan R Clarke
Jun 16, 2011
Myeloproliferative neoplasms
Substantial progress has been made in our understanding of the pathogenetic basis of myeloproliferative neoplasms. The discovery of mutations in JAK2 over a decade ago heralded a new age for patient care as a consequence of...
The JAK-STAT signaling pathway is differentially activated in CALR-positive compared with JAK2V617F-positive ET patients.
This is a metadata record relating to an article that cannot be shared due to publisher copyright.
Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.
Justyna A Kucia-Tran, Valtteri Tulkki, Stephen Smith, Cinzia G Scarpini, Katherine Hughes, Angela M Araujo, Ka Yin Matthew Yan, Jan Botthof, Eduardo Pérez-Gómez, Miguel Quintanilla, Kate Cuschieri, Maria M Caffarel, Nicholas Coleman
Jun 23, 2016
MicroRNA-101 expression is associated with JAK2V617F activity and regulates JAK2/STAT5 signaling.
Francesca Pagano, Federico Comoglio, Jacob Grinfeld, Juan Li, Anna Godfrey, Joanna Baxter, Yvonne Silber, Anthony R Green
Mar 19, 2018
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.
Paolo Gallipoli, Amy Cook, Susan Rhodes, Lisa Hopcroft, Helen Wheadon, Anthony D Whetton, Heather G Jørgensen, Ravi Bhatia, Tessa L Holyoake
Aug 11, 2017
Animals Antigens CD34 Antineoplastic Combined Chemotherapy Protocols Apoptosis Drug Synergism Fusion Proteins bcr-abl Humans Janus Kinase 2 Leukemia Myelogenous Chronic BCR-ABL Positive Mice Mice Inbred NOD Mice SCID Protein Kinase Inhibitors Pyrazoles Pyrimidines STAT5 Transcription Factor Signal Transduction Tumor Cells Cultured Tumor Stem Cell Assay Xenograft Model Antitumor Assays
Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms.
Animals Cell Division Cell Transformation Neoplastic Clone Cells Cytokines Epigenesis Genetic evolution Molecular Gene Dosage Gene Knock-In Techniques Genetic Heterogeneity Hematopoietic Stem Cells Humans Janus Kinase 2 Leukemia Myeloid Models Genetic Multipotent Stem Cells Mutation Missense Myeloproliferative Disorders Neoplasm Proteins Neoplastic Stem Cells Phenotype Point Mutation RNA Splicing selection Genetic Signal Transduction Transcription Factors
STAT1 activation in association with JAK2 exon 12 mutations.
Anna L Godfrey, Edwin Chen, Charles E Massie, Yvonne Silber, Francesca Pagano, Beatriz Bellosillo, Paola Guglielmelli, Claire N Harrison, John T Reilly, Frank Stegelmann, Fontanet Bijou, Eric Lippert, Jean-Michel Boiron, Konstanze Döhner, Alessandro M Vannucchi, Carlos Besses, Anthony R Green
Oct 06, 2015
Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal.
Mairi S Shepherd, Juan Li, Nicola K Wilson, Caroline A Oedekoven, Jiangbing Li, Miriam Belmonte, Juergen Fink, Janine CM Prick, Dean C Pask, Tina L Hamilton, Dirk Loeffler, Anjana Rao, Timm Schröder, Berthold Göttgens, Anthony R Green, David G Kent
Nov 01, 2018
Classification and Personalized Prognosis in Myeloproliferative Neoplasms.
Jacob Grinfeld, Jyoti Nangalia, E Joanna Baxter, David C Wedge, Nicos Angelopoulos, Robert Cantrill, Anna L Godfrey, Elli Papaemmanuil, Gunes Gundem, Cathy MacLean, Julia Cook, Laura O'Neil, Sarah O'Meara, Jon W Teague, Adam P Butler, Charlie E Massie, Nicholas Williams, Francesca L Nice, Christen L Andersen, Hans C Hasselbalch, Paola Guglielmelli, Mary F McMullin, Alessandro M Vannucchi, Claire N Harrison, Moritz Gerstung, Anthony R Green, Peter J Campbell
Oct 03, 2018
Determination of complex subclonal structures of hematological malignancies by multiplexed genotyping of blood progenitor colonies.
Alleles Clone Cells Cluster Analysis DNA Mutational Analysis DNA Neoplasm Erythroid Precursor Cells Genotyping Techniques Granulocytes Hematologic Neoplasms High-Throughput Nucleotide Sequencing Humans Janus Kinase 2 Mutation Mutation Missense Polycythemia Vera Polymorphism Single Nucleotide Sequence Analysis DNA
JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation.
Apoptosis Cell Line Tumor DNA Damage Female Forkhead Box Protein O3 Gene Expression Regulation Neoplastic Hematopoietic Stem Cells Humans Janus Kinase 2 Male Mutation Myeloproliferative Disorders Neoplasms Phosphatidylinositol 3-Kinases Reactive Oxygen Species Sodium-Hydrogen Exchangers bcl-X Protein
Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment
K Kirschner, T Chandra, V Kiselev, D Flores-Santa Cruz, IC Macaulay, HJ Park, J Li, DG Kent, R Kumar, DC Pask, TL Hamilton, M Hemberg, W Reik, AR Green
Jul 26, 2017
Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown. Using single-cell transcriptomics, we identified a distinct...
Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.
Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Sylwia Flis, Bac Viet Le, Martyna Solecka, Elizaveta A Belyaeva, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, Huaqing Zhao, Josef T Prchal, Katarzyna Piwocka, Alison R Moliterno, Mariusz Wasik, Steffen Koschmieder, Tony R Green, Radek C Skoda, Tomasz Skorski
May 31, 2018
Myeloproliferative neoplasms (MPNs) often carry JAK2(V617F), MPL(W515L), or CALR(del52) mutations. Current treatment options for MPNs include cytoreduction by hydroxyurea and JAK1/2 inhibition by ruxolitinib, both of which are...
Edwin Chen, Jong Sook Ahn, David B Sykes, Lawrence J Breyfogle, Anna L Godfrey, Jyoti Nangalia, Amy Ko, Daniel J DeAngelo, Anthony R Green, Ann Mullally
Oct 28, 2015
Animals Apoptosis Cell Line Tumor Cell Survival DNA Breaks Double-Stranded DNA Replication Furans Gene Knock-In Techniques Genomic Instability Humans Hydroxyurea Janus Kinase 2 Mice Mice Inbred C57BL Mutagenesis Site-Directed Neoplasms Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Pyridines Pyrimidines RNA Interference RNA Small Interfering RecQ Helicases Signal Transduction
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.
Shivam Rai, Elodie Grockowiak, Nils Hansen, Damien Luque Paz, Cedric B Stoll, Hui Hao-Shen, Gabriele Mild-Schneider, Stefan Dirnhofer, Christopher J Farady, Simón Méndez-Ferrer, Radek C Skoda
Oct 15, 2022
Interleukin-1β (IL-1β) is a master regulator of inflammation. Increased activity of IL-1β has been implicated in various pathological conditions including myeloproliferative neoplasms (MPNs). Here we show that IL-1β serum levels...