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Results: 11
EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors.
Aurelie Lenaerts, Iwo Kucinski, Ward Deboutte, Marta Derecka, Pierre Cauchy, Thomas Manke, Berthold Göttgens, Rudolf Grosschedl
Oct 01, 2022
Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina.
Lázaro Centanin, Janina-J Ander, Burkhard Hoeckendorf, Katharina Lust, Tanja Kellner, Isabel Kraemer, Cedric Urbany, Eva Hasel, William A Harris, Benjamin D Simons, Joachim Wittbrodt
Sep 30, 2014
Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.
Eric M Pietras, Damien Reynaud, Yoon-A Kang, Daniel Carlin, Fernando J Calero-Nieto, Andrew D Leavitt, Joshua M Stuart, Berthold Göttgens, Emmanuelle Passegué
Jun 11, 2015
Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors.
Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor.
Martin Wahlestedt, Vasileios Ladopoulos, Isabel Hidalgo, Manuel Sanchez Castillo, Rebecca Hannah, Petter Säwén, Haixia Wan, Monika Dudenhöffer-Pfeifer, Mattias Magnusson, Gudmundur L Norddahl, Berthold Göttgens, David Bryder
Jun 27, 2018
Gene regulation Hematopoiesis Lineage commitment lymphopoiesis Myelopoiesis Transcription factor Animals Basic-Leucine Zipper Transcription Factors Cell Differentiation Cell Lineage Gene Expression Regulation Hematopoiesis Hematopoietic Stem Cells Leukemia Lymphopoiesis Mice Multipotent Stem Cells Myeloid Cells
Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms.
Animals Cell Division Cell Transformation Neoplastic Clone Cells Cytokines Epigenesis Genetic evolution Molecular Gene Dosage Gene Knock-In Techniques Genetic Heterogeneity Hematopoietic Stem Cells Humans Janus Kinase 2 Leukemia Myeloid Models Genetic Multipotent Stem Cells Mutation Missense Myeloproliferative Disorders Neoplasm Proteins Neoplastic Stem Cells Phenotype Point Mutation RNA Splicing selection Genetic Signal Transduction Transcription Factors
Clonal dynamics of haematopoiesis across the human lifespan.
Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J Dawson, Nicole Mende, Emily F Calderbank, Hyunchul Jung, Thomas Mitchell, Tim HH Coorens, David H Spencer, Heather Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A Fabre, Krishnaa Mahbubani, Federico Abascal, Alex Cagan, George S Vassiliou, Joanna Baxter, Inigo Martincorena, Michael R Stratton, David G Kent, Krishna Chatterjee, Kourosh Saeb Parsy, Anthony R Green, Jyoti Nangalia, Elisa Laurenti, Peter J Campbell
Jul 02, 2022
Aline Wuidart, Marielle Ousset, Steffen Rulands, Benjamin D Simons, Alexandra Van Keymeulen, Cédric Blanpain
Jun 09, 2016
Niche stiffness underlies the ageing of central nervous system progenitor cells.
Michael Segel, Björn Neumann, Myfanwy FE Hill, Isabell P Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C Agley, Amelia J Thompson, Ginez A Gonzalez, Amar Sharma, Steffan Holmqvist, David H Rowitch, Kristian Franze, Robin Jm Franklin, Kevin J Chalut
Aug 21, 2019
Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells.
Xiaoping Bao, Xiaojun Lian, Kaitlin K Dunn, Mengxuan Shi, Tianxiao Han, Tongcheng Qian, Vijesh J Bhute, Scott G Canfield, Sean P Palecek
Jun 21, 2018
Human pluripotent stem cell (hPSC)-derived endothelial cells and their progenitors are important for vascular research and therapeutic revascularization. Here, we report a completely defined endothelial progenitor...
Distinct routes of lineage development reshape the human blood hierarchy across ontogeny.
Faiyaz Notta, Sasan Zandi, Naoya Takayama, Stephanie Dobson, Olga I Gan, Gavin Wilson, Kerstin B Kaufmann, Jessica McLeod, Elisa Laurenti, Cyrille F Dunant, John D McPherson, Lincoln D Stein, Yigal Dror, John E Dick
Oct 27, 2015