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Results: 176
Properties of the tapasin homologue TAPBPR
Recombinant amyloid beta-peptide production by coexpression with an affibody ligand.
Bertil Macao, Wolfgang Hoyer, Anders Sandberg, Ann-Christin Brorsson, Christopher M Dobson, Torleif Härd
Jun 14, 2011
Evidence for biased agonists and antagonists at the endothelin receptors.
Janet J Maguire
Feb 18, 2016
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.
Yuteng Wu, Lasse B Olsen, Yu Heng Lau, Claus Hatt Jensen, Maxim Rossmann, Ysobel R Baker, Hannah F Sore, Súil Collins, David R Spring
Mar 01, 2016
Serine-Selective Bioconjugation.
Julien C Vantourout, Srinivasa Rao Adusumalli, Kyle W Knouse, Dillon T Flood, Antonio Ramirez, Natalia M Padial, Alena Istrate, Katarzyna Maziarz, Justine N deGruyter, Rohan R Merchant, Jennifer X Qiao, Michael A Schmidt, Michael J Deery, Martin D Eastgate, Philip E Dawson, Gonçalo JL Bernardes, Phil S Baran
Sep 25, 2020
This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides, which uses a reagent platform based on the P(V) oxidation state. This...
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Irina Kufareva, Benoit Bestgen, Paul Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Celine F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan
Nov 03, 2020
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by...
Adenosine Triphosphate Binding Sites Casein Kinase II Catalytic Domain Cell Line Tumor Cell Movement Cell Proliferation Crystallography X-Ray Holoenzymes Humans Kinetics Molecular Docking Simulation Peptides Phosphorylation Protein Kinase Inhibitors Protein Subunits Substrate Specificity Surface Plasmon Resonance
Efficient and exact sampling of transition path ensembles on Markovian networks.
The problem of flickering trajectories in standard kinetic Monte Carlo (kMC) simulations prohibits sampling of the transition path ensembles (TPEs) on Markovian networks representing many slow dynamical processes of interest. In...
DIA label-free proteomic analysis of murine bone-marrow-derived macrophages.
Christa P Baker, Iain R Phair, Alejandro J Brenes, Abdelmadjid Atrih, Dylan G Ryan, Roland Bruderer, Albena T Dinkova-Kostova, Douglas J Lamont, J Simon C Arthur, Andrew JM Howden
Oct 28, 2022
Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation...
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy.
Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein, Roger Pocock
Dec 10, 2019
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival....
C. elegans Autophagy Biochemistry chemical biology Genetics Genomics human cells mammalian cells microRNA protein aggregation 3' Untranslated Regions Animals Autophagy Base Sequence Caenorhabditis elegans Caenorhabditis elegans Proteins GTPase-Activating Proteins HeLa Cells Humans Huntingtin Protein Interferon-beta Mice MicroRNAs Mutant Proteins Peptides Protein Aggregates RNA Messenger rab GTP-Binding Proteins rab7 GTP-Binding Proteins
Peptide dendrimer/lipid hybrid systems are efficient DNA transfection reagents
Efficient DNA delivery into cells is the prerequisite of the genetic manipulation of organisms in molecular and cellular biology as well as, ultimately, in nonviral gene therapy. Current reagents, however, are relatively...
Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice.
Ryan A Lafferty, Neil Tanday, R Charlotte Moffett, Frank Reimann, Fiona M Gribble, Peter R Flatt, Nigel Irwin
Jan 29, 2021
Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY(1-36) (SL-PYY(1-36)), are believed to improve glucose regulation in diabetes by targeting pancreatic islets. In this study...
Diabetes Peptide YY sea lamprey PYY streptozotocin transdifferentiation Animals Bacterial Proteins Blood Glucose Cell Differentiation Diabetes mellitus Experimental Glucagon Glucagon-Secreting Cells Insulin Insulin-Secreting Cells Islets of Langerhans Luminescent Proteins Mice Mice Inbred C57BL Neuropeptide Y Peptides Petromyzon Streptozocin Transgenes
Organoid Sample Preparation and Extraction for LC-MS Peptidomics.
Emily L Miedzybrodzka, Rachel E Foreman, Sam G Galvin, Pierre Larraufie, Amy L George, Deborah A Goldspink, Frank Reimann, Fiona M Gribble, Richard G Kay
Mar 18, 2021
This protocol describes the peptidomic analysis of organoid lysates, FACS-purified cell populations, and 2D culture secretions by liquid chromatography mass spectrometry (LC-MS). Currently, most peptides are quantified by ELISA...
The Road to Stockholm: [Dr. Bruce Merrifield]
Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual...
Merrifield Bruce Rockefeller University Scientists Peptides Peptide Hormones solid-phase peptide synthesis Life Sciences
Published by: The Rockefeller University
Light-triggered syneresis of a water insoluble peptide-hydrogel effectively removes small molecule waste contaminants.
A short peptide based hydrogel exhibits aqueous insolubility, thixotropy and efficient light induced syneresis. Upon irradiation with UV light, the hydrogel shrinks and expells ∼50% of the solvent. Syneresis is caused by...
Improved Ribo-seq enables identification of cryptic translation events.
Florian Erhard, Anne Halenius, Cosima Zimmermann, Anne L'Hernault, Daniel J Kowalewski, Michael P Weekes, Stefan Stevanovic, Ralf Zimmer, Lars Dölken
May 04, 2018
Ribosome profiling has been used to predict thousands of short open reading frames (sORFs) in eukaryotic cells, but it suffers from substantial levels of noise. PRICE (https://github.com/erhard-lab/price) is a computational...
TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst.
Clemens Hermann, Andy van Hateren, Nico Trautwein, Andreas Neerincx, Patrick J Duriez, Stefan Stevanović, John Trowsdale, Janet E Deane, Tim Elliott, Louise H Boyle
Aug 09, 2017
Assessing the degradation of ancient milk proteins through site-specific deamidation patterns.
Abigail Ramsøe, Mia Crispin, Meaghan Mackie, Krista McGrath, Roman Fischer, Beatrice Demarchi, Matthew J Collins, Jessica Hendy, Camilla Speller
Feb 02, 2022
The origins, prevalence and nature of dairying have been long debated by archaeologists. Within the last decade, new advances in high-resolution mass spectrometry have allowed for the direct detection of milk proteins from...
TAPBPR
TAPBPR/TAPBPL antigen processing and presentation disease association human major histocompatibility complex (MHC) tapasin Amino Acid Sequence Antigen Presentation Antigen-Presenting Cells Cell Membrane Endoplasmic Reticulum Gene Expression Histocompatibility Antigens Class I Humans Immunoglobulins Membrane Proteins Membrane Transport Proteins Models Molecular Molecular Sequence Data Peptides Protein Transport Signal Transduction
Predicted mouse peroxisome-targeted proteins and their actual subcellular locations.
Unique charge-dependent constraint on collagen recognition by integrin α10β1.
Samir W Hamaia, Daisy Luff, Emma J Hunter, Jean-Daniel Malcor, Dominique Bihan, Donald Gullberg, Richard W Farndale
Oct 31, 2016
C2C12 cells Cartilage GROGER Integrin I domain Triple-helical peptides Amino Acid Motifs Amino Acid Sequence Animals Binding Sites cations Divalent Cell Line Collagen Type II Edetic Acid Gene Expression Humans Integrin alpha Chains Magnesium Mice Models Molecular Muscle Fibers Skeletal Peptides Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Recombinant Proteins Sequence Alignment Static Electricity
Inhibition of Ral GTPases Using a Stapled Peptide Approach.
Jemima C Thomas, Jonathan M Cooper, Natasha S Clayton, Chensu Wang, Michael A White, Chris Abell, Darerca Owen, Helen R Mott
Aug 01, 2016
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans.
Romain F Laine, Tessa Sinnige, Kai Yu Ma, Amanda J Haack, Chetan Poudel, Peter Gaida, Nathan Curry, Michele Perni, Ellen AA Nollen, Christopher M Dobson, Michele Vendruscolo, Gabriele S Kaminski Schierle, Clemens F Kaminski
May 24, 2019
The nematode worm Caenorhabditis elegans has emerged as an important model organism in the study of the molecular mechanisms of protein misfolding diseases associated with amyloid formation because of its small size, ease of...
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