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The Impact of the C-Terminal Region on the Interaction of Topoisomerase II Alpha with Mitotic Chromatin.
Type II topoisomerase enzymes are essential for resolving DNA topology problems arising through various aspects of DNA metabolism. In vertebrates two isoforms are present, one of which (TOP2A) accumulates on chromatin during...
C-terminal domain SUMO Centromere CHROMOSOME Mitosis Phosphorylation post-translational modification topoisomerase II alpha Anaphase Cell Line Centromere Chromatin DNA Topoisomerases Type II DNA-Binding Proteins HEK293 Cells Humans Metaphase Phosphorylation Poly-ADP-Ribose Binding Proteins Protein Processing Post-Translational Small Ubiquitin-Related Modifier Proteins Sumoylation
Trafficking and processing of bacterial proteins by mammalian cells
Elizabeth Muir, Mansoor Raza, Clare Ellis, Emily Burnside, Fiona Love, Simon Heller, Matthew Elliot, Esther Daniell, Debayan Dasgupta, Nuno Alves, Priscilla Day, James Fawcett, Roger Keynes
Feb 07, 2018
BACKGROUND: There is very little reported in the literature about the relationship between modifications of bacterial proteins and their secretion by mammalian cells that synthesize them. We previously reported that the...
Bilateral giant retinal tears in Osteogenesis Imperfecta.
Humans osteogenesis imperfecta Retinal Detachment Retinal Perforations Collagen Type I Collagen Type II Collagen Type V Proteoglycans Membrane Glycoproteins Protein Processing Post-Translational Genes Recessive Child Male Genetic Testing Prolyl Hydroxylases
Published by: BMC medical genetics
Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Theodoros Goulas, Danuta Mizgalska, Irene Garcia-Ferrer, Tomasz Kantyka, Tibisay Guevara, Borys Szmigielski, Aneta Sroka, Claudia Millán, Isabel Usón, Florian Veillard, Barbara Potempa, Piotr Mydel, Maria Solà, Jan Potempa, F Xavier Gomis-Rüth
Oct 19, 2020
Citrullination is a post-translational modification of higher organisms that deiminates arginines in proteins and peptides. It occurs in physiological processes but also pathologies such as multiple sclerosis, fibrosis...
Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle.
John A Halsall, Simon Andrews, Felix Krueger, Charlotte E Rutledge, Gabriella Ficz, Wolf Reik, Bryan M Turner
Apr 12, 2021
Chromatin configuration influences gene expression in eukaryotes at multiple levels, from individual nucleosomes to chromatin domains several Mb long. Post-translational modifications (PTM) of core histones seem to be involved...
Chemical and Enzymatic Methods for Post-Translational Protein-Protein Conjugation.
Fusion proteins play an essential role in the biosciences but suffer from several key limitations, including the requirement for N-to-C terminal ligation, incompatibility of constituent domains, incorrect folding, and loss of...
Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin.
Shirong Yu, Katie Evans, Patrick van Eijk, Mark Bennett, Richard M Webster, Matthew Leadbitter, Yumin Teng, Raymond Waters, Stephen P Jackson, Simon H Reed
Sep 13, 2016
Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.
Michael S Nahorski, Sateesh Maddirevula, Ryosuke Ishimura, Saud Alsahli, Angela F Brady, Anaïs Begemann, Tsunehiro Mizushima, Francisco J Guzmán-Vega, Miki Obata, Yoshinobu Ichimura, Hessa S Alsaif, Shams Anazi, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Dorota Monies, Mohamed Abouelhoda, Brian F Meyer, Majid Alfadhel, Wafa Eyaid, Markus Zweier, Katharina Steindl, Anita Rauch, Stefan T Arold, C Geoffrey Woods, Masaaki Komatsu, Fowzan S Alkuraya
Apr 30, 2018
The post-translational modification of proteins through the addition of UFM1, also known as ufmylation, plays a critical developmental role as revealed by studies in animal models. The recent finding that biallelic mutations in...
Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.
Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, RA John Challiss, Flaviano Giorgini, Joern R Steinert
Jul 18, 2018
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as...
Adaptor Proteins Vesicular Transport Aldehyde Oxidoreductases Animals Brain Cyclic GMP Drosophila Proteins Drosophila melanogaster Glutamate-Cysteine Ligase Glutathione Larva Nerve Tissue Proteins Neuromuscular Junction Neurotransmitter Agents Nitric oxide Phenotype Prenylation Protein Processing Post-Translational SNARE Proteins Synaptic Transmission Synaptic Vesicles
Differential expression of selected histone modifier genes in human solid cancers.
Hilal Ozdağ, Andrew E Teschendorff, Ahmed Ashour Ahmed, Sarah J Hyland, Cherie Blenkiron, Linda Bobrow, Abhi Veerakumarasivam, Glynn Burtt, Tanya Subkhankulova, Mark J Arends, V Peter Collins, David Bowtell, Tony Kouzarides, James D Brenton, Carlos Caldas
Jun 14, 2011
Breast Neoplasms Carcinoma Cell Transformation Neoplastic Cluster Analysis Colorectal Neoplasms DNA Complementary DNA Neoplasm Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Histone Acetyltransferases Histone Code Histone Deacetylases Histone Methyltransferases Histone-Lysine N-Methyltransferase Histones Humans Linear Models Lung Neoplasms Male Neoplasm Proteins Neoplasms Ovarian Neoplasms Pancreatic Neoplasms Polymerase Chain Reaction Polymorphism Single-Stranded Conformational Protein Methyltransferases Protein Processing Post-Translational
Disordered domains in chromatin-binding proteins.
Chromatin comprises proteins, DNA and RNA, and its function is to condense and package the genome in a way that allows the necessary transactions such as transcription, replication and repair to occur in a highly organised and...
A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
Petra Mlcochova, Katherine A Sutherland, Sarah A Watters, Cosetta Bertoli, Rob Am de Bruin, Jan Rehwinkel, Stuart J Neil, Gina M Lenzi, Baek Kim, Asim Khwaja, Matthew C Gage, Christiana Georgiou, Alexandra Chittka, Simon Yona, Mahdad Noursadeghi, Greg J Towers, Ravindra K Gupta
Sep 18, 2019
An unresolved question is how HIV-1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle-associated proteins...
Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization.
Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in a variety of tumor types, most notably in Anaplastic Large Cell Lymphoma (ALCL) where a chromosomal translocation generates the oncogenic...
Anaplastic Lymphoma Kinase Animals Cell Adhesion Cell Cycle Cell Proliferation Cell Transformation Neoplastic Cells Cultured Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Embryo Mammalian FIBROBLASTS Humans Mice Models Biological Mutation Protein Processing Post-Translational Protein Stability Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases Retinoblastoma Protein Transcription Genetic Tumor Suppressor Protein p53
Ribosome collisions trigger cis-acting feedback inhibition of translation initiation.
Szymon Juszkiewicz, Greg Slodkowicz, Zhewang Lin, Paula Freire-Pritchett, Sew-Yeu Peak-Chew, Ramanujan S Hegde
Jul 25, 2020
Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate protein and mRNA quality control pathways. Here we...
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways.
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C Costa, Samantha HY Loh, L Miguel Martins
Jul 20, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson's disease caused by...
Drosophila Drosophila protein kinase RNA (PKR)-like ER kinase (dPerk) ER stress activating transcription factor 4 (ATF4) Unfolded Protein Response Activating Transcription Factor 4 Animals Cell Cycle Proteins Computational Biology Drosophila Proteins Drosophila melanogaster Endoplasmic Reticulum Endoplasmic reticulum stress Eukaryotic Initiation Factor-2 HEAT-SHOCK PROTEINS Mitochondria Neurodegenerative Diseases Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases Proteomics Signal Transduction Transcription Factors Transcriptome Ubiquitin-Protein Ligases Unfolded Protein Response eIF-2 Kinase
Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1.
Yun Hsiao Lin, Yue Liang, Hanchen Wang, Lin Tze Tung, Michael Förster, Poorani Ganesh Subramani, Javier M Di Noia, Simon Clare, David Langlais, Anastasia Nijnik
Jun 07, 2021
BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, via deubiquitination of histone H2AK119ub and other substrates. BAP1 is an important...
B Cell Development B cells epigenetic regulation Mouse models Transcriptional regulation Animals B-Lymphocytes Cell Lineage Cell Proliferation Cells Cultured Epigenesis Genetic Female Gene Expression Regulation Developmental Histones Lymphocyte Activation Male Mice Inbred C57BL Mice Knockout Phenotype Precursor Cells B-Lymphoid Protein Processing Post-Translational Transcription Genetic Tumor Suppressor Proteins Ubiquitin Thiolesterase Ubiquitination
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates.
Rosie Bell, Rebecca J Thrush, Marta Castellana-Cruz, Marc Oeller, Roxine Staats, Aishwarya Nene, Patrick Flagmeier, Catherine K Xu, Sandeep Satapathy, Celine Galvagnion, Mark R Wilson, Christopher M Dobson, Janet R Kumita, Michele Vendruscolo
Sep 12, 2022
Parkinson's disease is associated with the aberrant aggregation of α-synuclein. Although the causes of this process are still unclear, post-translational modifications of α-synuclein are likely to play a modulatory role. Since...
A redox switch in angiotensinogen modulates angiotensin release.
Aiwu Zhou, Robin W Carrell, Michael P Murphy, Zhenquan Wei, Yahui Yan, Peter LD Stanley, Penelope E Stein, Fiona Broughton Pipkin, Randy J Read
May 11, 2020
Blood pressure is critically controlled by angiotensins, which are vasopressor peptides specifically released by the enzyme renin from the tail of angiotensinogen-a non-inhibitory member of the serpin family of protease...
The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.
Peter St George-Hyslop, Julie Qiaojin Lin, Akinori Miyashita, Emma C Phillips, Seema Qamar, Suzanne J Randle, GuoZhen Wang
Sep 05, 2018
Amyotrophic Lateral Sclerosis arginine methylation Cation-pi interactions frontotemporal dementia phase separation RNA binding proteins Amyotrophic Lateral Sclerosis biophysics Cytoplasmic Granules DNA-Binding Proteins frontotemporal dementia Frontotemporal Lobar Degeneration Humans Mutation Neurodegenerative Diseases Protein Domains Protein Processing Post-Translational RNA-Binding Protein FUS RNA-Binding Proteins Temporal Lobe
Ubiquitin-Like Modifiers
Post-translational protein regulation allows for fine-tuning of cellular functions and involves a wide range of modifications, including ubiquitin and ubiquitin-like modifiers (Ubls). The dynamic balance of Ubl...
ATG12 ATG8 NEDD8 SUMO UFM1 URM1 PARASITE post- translational regulation protozoa ubiquitin-like Autophagy-Related Protein 12 Autophagy-Related Protein 8 Family Autophagy-Related Proteins host-parasite interactions Humans NEDD8 Protein Protein Processing Post-Translational SUMO-1 Protein Signal Transduction Ubiquitins
Wrapping up the bad news
Calcium-Binding Proteins Cell Cycle Proteins Endosomal Sorting Complexes Required for Transport HIV Infections HIV-1 Host-Pathogen Interactions Humans Nedd4 Ubiquitin Protein Ligases Protein Processing Post-Translational Proteolysis Ubiquitin-Protein Ligases Virus Assembly Virus Release gag Gene Products Human Immunodeficiency Virus
The ubiquitin family meets the Fanconi anemia proteins.
Fanconi anaemia (FA) is a hereditary disorder characterized by bone marrow failure, developmental defects, predisposition to cancer and chromosomal abnormalities. FA is caused by biallelic mutations that inactivate genes...
Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1.
RNA-binding protein axon sorting topography visual system Animals Axons Embryo Nonmammalian Gene Knockdown Techniques Growth Cones Neuropilin-1 Protein Processing Post-Translational RNA-Binding Proteins Retinal Ganglion Cells Semaphorin-3A Superior Colliculi Visual Pathways Xenopus Proteins Xenopus laevis Zebrafish
Evidence that a positive feedback loop drives centrosome maturation in fly embryos.
Ines Alvarez-Rodrigo, Thomas L Steinacker, Saroj Saurya, Paul T Conduit, Janina Baumbach, Zsofia A Novak, Mustafa G Aydogan, Alan Wainman, Jordan W Raff
Oct 31, 2019
Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter mitosis (a process termed centrosome maturation), but it is unclear...
D. melanogaster Spd-2 Cell Biology centriole Centrosome feedback loop pericentriolar material polo kinase Animals Centrosome Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Feedback Physiological Homeodomain Proteins Mitosis Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases
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