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Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery.
Gonzalo Millan-Zambrano, Helena Santos-Rosa, Fabio Puddu, Samuel C Robson, Stephen P Jackson, Tony Kouzarides
Dec 03, 2018
Cla4 DNA damage checkpoint H4T80ph PAK Rad53 Rad9 Rtt107 Histone modifications Cell Cycle Checkpoints Cell Cycle Proteins Checkpoint Kinase 2 DNA Damage DNA Repair Histones Intracellular Signaling Peptides and Proteins Nuclear Proteins Phosphorylation Protein Binding Protein Serine-Threonine Kinases Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction
Genome-wide Estrogen Receptor-α activation is sustained, not cyclical.
Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern....
Estrogen estrogen receptor MCF7 Breast Cancer Chromosomes Computational Biology endocrine Gene Expression human Systems Biology Base Sequence Binding Sites Estradiol Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Genome Human Genome-Wide Association Study Humans MCF-7 Cells Neoplasm Proteins Promoter Regions Genetic Protein Binding Receptors CXCR Signal Transduction Sorting Nexins Trefoil Factor-1
Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.
Michael E Reschen, Kyle J Gaulton, Da Lin, Elizabeth J Soilleux, Andrew J Morris, Susan S Smyth, Christopher A O'Callaghan
Dec 17, 2018
Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of coronary artery disease (CAD) and the causal mechanisms at the majority of loci are unknown. Recent studies have suggested that many causal...
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein
Michael D Crabtree, Wade Borcherds, Anusha Poosapati, Sarah L Shammas, Gary W Daughdrill, Jane Clarke
Mar 26, 2018
Appropriate integration of cellular signals requires a delicate balance of ligand-target binding affinities. Increasing the level of residual structure in intrinsically disordered proteins (IDPs), which are overrepresented in...
Amino Acid Sequence Animals Binding Sites Cloning Molecular Conserved Sequence Escherichia coli Gene Expression Histone-Lysine N-Methyltransferase Humans Intrinsically Disordered Proteins Membrane Proteins Mice Models Molecular Mutation Myeloid-Lymphoid Leukemia Protein Phosphoproteins Proline Protein Binding Protein Conformation alpha-Helical Protein Folding Protein Interaction Domains and Motifs Recombinant Proteins Sequence Alignment Sequence Homology Amino Acid Tumor Suppressor Protein p53
Long-Range Enhancer Interactions Are Prevalent in Mouse Embryonic Stem Cells and Are Reorganized upon Pluripotent State Transition.
Clara Lopes Novo, Biola-Maria Javierre, Jonathan Cairns, Anne Segonds-Pichon, Steven W Wingett, Paula Freire-Pritchett, Mayra Furlan-Magaril, Stefan Schoenfelder, Peter Fraser, Peter J Rugg-Gunn
May 10, 2018
chromatin looping DIFFERENTIATION epigenetics Gene regulation genome organization Pluripotency promoter capture Hi-C Animals Cell Differentiation Enhancer Elements Genetic Gene Regulatory Networks Germ Layers Mice Mouse embryonic stem cells Nanog Homeobox Protein Pluripotent Stem Cells Promoter Regions Genetic Protein Binding
CTCF maintains regulatory homeostasis of cancer pathways.
Sarah J Aitken, Ximena Ibarra-Soria, Elissavet Kentepozidou, Paul Flicek, Christine Feig, John C Marioni, Duncan T Odom
Sep 20, 2018
CTCF Cancer Chromatin architecture chromatin state Hemizygosity Transcription Animals Breast Neoplasms CCCTC-Binding Factor Cell Line Chromatin DNA Neoplasm Enhancer Elements Genetic Female FIBROBLASTS Gene Expression Regulation Neoplastic Genome Hemizygote Homeostasis Humans Liver Neoplasms Experimental Mice Mice Inbred C57BL Mice Transgenic Protein Binding Signal Transduction Uterine Neoplasms
Targeted DamID reveals differential binding of mammalian pluripotency factors.
Seth W Cheetham, Wolfram H Gruhn, Jelle van den Ameele, Robert Krautz, Tony D Southall, Toshihiro Kobayashi, M Azim Surani, Andrea H Brand
Oct 03, 2018
The precise control of gene expression by transcription factor networks is crucial to organismal development. The predominant approach for mapping transcription factor-chromatin interactions has been chromatin...
Allostery and dynamics in small G proteins.
The Ras family of small guanine nucleotide-binding proteins behave as molecular switches: they are switched off and inactive when bound to GDP but can be activated by GTP binding in response to signal transduction pathways....
Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.
Claudia Russo, Christian Osterburg, Anna Sirico, Dario Antonini, Raffaele Ambrosio, Julia Maren Würz, Jörg Rinnenthal, Marco Ferniani, Sebastian Kehrloesser, Birgit Schäfer, Peter Güntert, Satrajit Sinha, Volker Dötsch, Caterina Missero
Aug 31, 2018
AEC syndrome mouse model p63 protein aggregation Skin Animals Cleft Lip Cleft Palate Ectoderm Eye Abnormalities Frameshift Mutation HEK293 Cells Heterozygote Humans Mice Mutation Mutation Missense Phosphoproteins Protein Binding Protein Denaturation Skin Trans-Activators Transcription Factors Transcription Genetic Tumor Suppressor Proteins
Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis.
Daffolyn Rachael Fels Elliott, Juliane Perner, Xiaodun Li, Martyn F Symmons, Brett Verstak, Matthew Eldridge, Lawrence Bower, Maria O'Donovan, Nick J Gay, OCCAMS consortium, Rebecca C Fitzgerald
Nov 01, 2018
Esophageal adenocarcinoma (EAC) develops in an inflammatory microenvironment with reduced microbial diversity, but mechanisms for these influences remain poorly characterized. We hypothesized that mutations targeting the...
How release of phosphate from mammalian F1-ATPase generates a rotary substep.
The rotation of the central stalk of F1-ATPase is driven by energy derived from the sequential binding of an ATP molecule to its three catalytic sites and the release of the products of hydrolysis. In human F1-ATPase, each 360°...
ATP synthase Mitochondria phosphate release rotary substep Adenosine Diphosphate Animals Catalytic Domain Cattle Crystallography X-Ray Humans Hydrolysis Mitochondria Models Molecular Molecular Motor Proteins Phosphates Protein Binding Protein Structure Secondary Proton-Translocating ATPases Temperature
Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.
Agnieszka Szymula, Richard D Palermo, Amr Bayoumy, Ian J Groves, Mohammed Ba Abdullah, Beth Holder, Robert E White
Jul 31, 2018
The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has...
Adult B-Lymphocytes Cell Transformation Viral Cells Cultured Epstein-Barr Virus Infections Female Gene Expression Regulation Viral Genome Viral HEK293 Cells Herpesvirus 4 Human Humans Infant Newborn Leukemia B-Cell Pregnancy Promoter Regions Genetic Protein Binding Transcription Factors Viral Proteins
The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Nikolai Schleussner, Olaf Merkel, Mariantonia Costanza, Huan-Chang Liang, Franziska Hummel, Chiara Romagnani, Pawel Durek, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Antonia Niedobitek, Patrick R Griffin, Roberto Piva, Henrike L Sczakiel, Wilhelm Woessmann, Christine Damm-Welk, Christian Hinze, Dagmar Stoiber, Bernd Gillissen, Suzanne D Turner, Eva Kaergel, Linda von Hoff, Michael Grau, Georg Lenz, Bernd Dörken, Claus Scheidereit, Lukas Kenner, Martin Janz, Stephan Mathas
Mar 20, 2018
Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK+ and ALK- anaplastic large cell lymphoma (ALCL). Here we demonstrate high-level BATF and BATF3 expression in ALCL. Both BATFs bind...
Basic-Leucine Zipper Transcription Factors Binding Sites CRISPR-Cas Systems Carrier Proteins Cell Death Cell Line Tumor Cell Survival Cytokines Gene Editing Gene Expression Regulation Neoplastic Gene Knockdown Techniques Humans Lymphoma Large-Cell Anaplastic Protein Binding Protein Kinase Inhibitors RNA Small Interfering T-Lymphocyte Subsets Th17 Cells Transcription Factor AP-1 Transcriptome
Mutations at protein-protein interfaces
Harry C Jubb, Arun P Pandurangan, Meghan A Turner, Bernardo Ochoa-Montaño, Tom L Blundell, David B Ascher
Jan 11, 2017
The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription
A Akay, T Di Domenico, KM Suen, A Nabih, GE Parada, M Larance, R Medhi, Berkyurek, X Zhang, CJ Wedeles, Rudolph, J Engelhardt, M Hemberg, P Ma, AI Lamond, JM Claycomb, Miska
Jul 16, 2017
Properties of the tapasin homologue TAPBPR
3D complex
Most of the proteins in a cell assemble into complexes to carry out their function. It is therefore crucial to understand the physicochemical properties as well as the evolution of interactions between proteins. The Protein Data...
Purification of Recombinant ESCRT-III Proteins and Their Use in Atomic Force Microscopy and In Vitro Binding and Phosphorylation Assays.
Luisa Capalbo, Ioanna Mela, Maria Alba Abad, A Arockia Jeyaprakash, J Michael Edwardson, Pier Paolo D'Avino
Oct 30, 2019
The endosomal sorting complex required for transport (ESCRT)-III proteins are known to assemble into filaments that mediate membrane remodeling and fission in various biological processes, including the formation of endosomal...
Atomic force microscopy CHMP4C Kinase assay Protein Binding Protein purification Chromatography Affinity Chromatography Gel Cloning Molecular Drosophila Proteins Endosomal Sorting Complexes Required for Transport Genetic Vectors Lipid Bilayers Microscopy Atomic Force Phosphorylation Plasmids Protein Binding Recombinant Proteins Transformation Bacterial
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.
Olivia JS Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J Savill, Svenja Hester, Sophie Ravel, Jack D Sunter, Camilla Trevor, Steven Rust, Tristan J Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C Taylor, Matthew K Higgins, Mark Carrington
Feb 19, 2020
PICALM modulates autophagy activity and tau accumulation.
Kevin Moreau, Angeleen Fleming, Sara Imarisio, Ana Lopez Ramirez, Jacob L Mercer, Maria Jimenez-Sanchez, Carla F Bento, Claudia Puri, Eszter Zavodszky, Farah Siddiqi, Catherine P Lavau, Maureen Betton, Cahir J O'Kane, Daniel S Wechsler, David C Rubinsztein
Oct 09, 2014
Animals Autophagy Autophagy-Related Protein 12 Cell Line Drosophila Endocytosis Female FIBROBLASTS Genome-Wide Association Study HEK293 Cells HeLa Cells Humans Male Mice Monomeric Clathrin Assembly Proteins Phagosomes Protein Binding RNA Small Interfering Risk Factors Small Ubiquitin-Related Modifier Proteins Transfection Vesicle-Associated Membrane Protein 2 Zebrafish tau Proteins
Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.
Liliane Chung, Dalan Bailey, Eoin N Leen, Edward P Emmott, Yasmin Chaudhry, Lisa O Roberts, Stephen Curry, Nicolas Locker, Ian G Goodfellow
Jul 09, 2014
Eukaryotic Translation Initiation Factor 4E (eIF4E) Norovirus Plus-stranded RNA Virus Translation Translation Initiation Factor VPg Virus eIF4G Base Sequence Chromatography Affinity DNA Primers Eukaryotic Initiation Factor-4G Genome Viral Norovirus Polymerase Chain Reaction Protein Binding Protein Biosynthesis Proteomics Viral Proteins
Progesterone receptor modulates ERα action in breast cancer.
Hisham Mohammed, I Alasdair Russell, Rory Stark, Oscar M Rueda, Theresa E Hickey, Gerard A Tarulli, Aurelien A Serandour, Stephen N Birrell, Alejandra Bruna, Amel Saadi, Suraj Menon, James Hadfield, Michelle Pugh, Ganesh V Raj, Gordon D Brown, Clive D'Santos, Jessica LL Robinson, Grace Silva, Rosalind Launchbury, Charles M Perou, John Stingl, Carlos Caldas, Wayne D Tilley, Jason S Carroll
Aug 13, 2015
Animals Breast Neoplasms Cell Line Tumor Cell Proliferation Chromatin DNA Copy Number Variations Disease Progression Estrogen Receptor alpha Estrogens Female Gene Expression Regulation Neoplastic Humans Ligands Mice Progesterone Protein Binding Receptors Progesterone Transcription Genetic Xenograft Model Antitumor Assays
The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.
Hebin Liu, Helga Schneider, Asha Recino, Christine Richardson, Martin W Goldberg, Christopher E Rudd
Aug 18, 2015
Active Transport Cell Nucleus Adaptor Proteins Signal Transducing Animals Cell Line GTPase-Activating Proteins Humans Jurkat Cells Mice Microscopy Electron Transmission NFATC Transcription Factors Nuclear Pore Phosphoproteins Protein Binding Small Ubiquitin-Related Modifier Proteins T-Lymphocytes Transcription Factor RelA
Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.
Cynthia Tallant, Erica Valentini, Oleg Fedorov, Lois Overvoorde, Fleur M Ferguson, Panagis Filippakopoulos, Dmitri I Svergun, Stefan Knapp, Alessio Ciulli
Feb 03, 2015
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