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Terminating the replication helicase.
A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48...
Serine-Selective Bioconjugation.
Julien C Vantourout, Srinivasa Rao Adusumalli, Kyle W Knouse, Dillon T Flood, Antonio Ramirez, Natalia M Padial, Alena Istrate, Katarzyna Maziarz, Justine N deGruyter, Rohan R Merchant, Jennifer X Qiao, Michael A Schmidt, Michael J Deery, Martin D Eastgate, Philip E Dawson, Gonçalo JL Bernardes, Phil S Baran
Sep 25, 2020
This Communication reports the first general method for rapid, chemoselective, and modular functionalization of serine residues in native polypeptides, which uses a reagent platform based on the P(V) oxidation state. This...
Role of the deubiquitylating enzyme DmUsp5 in coupling ubiquitin equilibrium to development and apoptosis in Drosophila melanogaster.
Protein ubiquitylation is a dynamic process that affects the function and stability of proteins and controls essential cellular processes ranging from cell proliferation to cell death. This process is regulated through the...
Structural plasticity of D3-D14 ubiquitin ligase in strigolactone signalling.
Nitzan Shabek, Fabrizio Ticchiarelli, Haibin Mao, Thomas R Hinds, Ottoline Leyser, Ning Zheng
Dec 11, 2018
The ubiquitin family meets the Fanconi anemia proteins.
Fanconi anaemia (FA) is a hereditary disorder characterized by bone marrow failure, developmental defects, predisposition to cancer and chromosomal abnormalities. FA is caused by biallelic mutations that inactivate genes...
A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.
Leo Kiss, Jingwei Zeng, Claire F Dickson, Donna L Mallery, Ji-Chun Yang, Stephen H McLaughlin, Andreas Boland, David Neuhaus, Leo C James
Oct 02, 2020
The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation...
Amino Acid Motifs Antiviral Restriction Factors Biocatalysis Crystallography X-Ray HEK293 Cells HeLa Cells Humans Lysine Models Molecular Mutation Nuclear Magnetic Resonance Biomolecular Protein Binding Ribonucleoproteins Tripartite Motif Proteins Ubiquitin Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitination
Dynamic transcriptional response of Saccharomyces cerevisiae cells to copper.
Copper is a crucial trace element for all living systems and any deficiency in copper homeostasis leads to the development of severe diseases in humans. The observation of extensive evolutionary conservation in copper...
Algorithms Cluster Analysis Computational Biology Copper Copper Transport Proteins Endocytosis Gene Deletion Gene Expression Regulation Fungal Homeostasis Homozygote Iron Mutation Oligonucleotide Array Sequence Analysis Phylogeny Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins sulfur Transcription Genetic Ubiquitin
Structure and Function of Fbxo7/PARK15 in Parkinson's Disease.
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis.
Alexandra D Almeida, Helen M Wise, Christopher J Hindley, Michael K Slevin, Rebecca S Hartley, Anna Philpott
Jun 13, 2011
BACKGROUND: The neural crest is a unique population of cells that arise in the vertebrate ectoderm at the neural plate border after which they migrate extensively throughout the embryo, giving rise to a wide range of...
Animals Blotting Western Cell Differentiation Cell Proliferation Cyclin E DNA Complementary F-Box Proteins F-Box-WD Repeat-Containing Protein 7 Gene Expression Regulation Developmental In Situ Hybridization Microinjections Neural Crest Plasmids Point Mutation Polymerase Chain Reaction Protein Isoforms RNA Messenger Sequence Deletion Ubiquitin Xenopus Proteins Xenopus laevis
Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O -GlcNAcylation
Bethany Mason, Susanne Flach, Felipe R. Teixeira, Raquel Manzano Garcia, Oscar M. Rueda, Jean E. Abraham, Carlos Caldas, Paul A. W. Edwards, Heike Laman
Jun 26, 2020
Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.
Spencer Hill, Kurt Reichermeier, Daniel C Scott, Lorena Samentar, Jasmin Coulombe-Huntington, Luisa Izzi, Xiaojing Tang, Rebeca Ibarra, Thierry Bertomeu, Annie Moradian, Michael J Sweredoski, Nora Caberoy, Brenda A Schulman, Frank Sicheri, Mike Tyers, Gary Kleiger
Jan 23, 2020
Biochemistry Cell Biology chemical biology cullin-RING ligase human protein degradation Ubiquitin ubiquitin ligases ubiquitin-conjugating enzyme Genome Human Humans Hypoxia-Inducible Factor 1 alpha Subunit Mass Spectrometry Polyubiquitin Signal Transduction Ubiquitin-Conjugating Enzymes Ubiquitin-Protein Ligases Ubiquitination
Developmental and tissue specific changes of ubiquitin forms in Drosophila melanogaster.
In most Eukaryotes, ubiquitin either exists as free monoubiquitin or as a molecule that is covalently linked to other proteins. These two forms cycle between each other and due to the concerted antagonistic activity of...
Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.
Bethany Mason, Susanne Flach, Felipe R Teixeira, Raquel Manzano Garcia, Oscar M Rueda, Jean E Abraham, Carlos Caldas, Paul AW Edwards, Heike Laman
Sep 18, 2019
Breast Cancer FBXL17 Genome rearrangements O-GlcNAc O-GlcNAcylation Phosphorylation UAP1 Ubiquitin Acetylglucosamine Breast Neoplasms Cell Line Tumor DNA Breaks F-Box Proteins Female HEK293 Cells Humans Phosphorylation Protein Processing Post-Translational Sequence Deletion Ubiquitin-Protein Ligases Ubiquitination
Role of Ubiquitin and Ubiquitin Ligases in Retroviral Budding
Maria Zhadina
Jan 01, 0001
The final stage in the production of infectious retroviral particles is the scission of membrane tethers connecting nascent virions to the host cell. Efficient retrovirus release requires late domains, short peptide motifs...
Ubiquitin virus particle budding retroviral particle release PFV Gag proteins HECT domain function Life Sciences
Published by: Rockefeller University
Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool.
Richard Wang, Camilla Ascanelli, Ahmed Abdelbaki, Alex Fung, Tim Rasmusson, Iacovos Michaelides, Karen Roberts, Catherine Lindon
May 03, 2021
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.
Barry Boland, Wai Haung Yu, Olga Corti, Bertrand Mollereau, Alexandre Henriques, Erwan Bezard, Greg M Pastores, David C Rubinsztein, Ralph A Nixon, Michael R Duchen, Giovanna R Mallucci, Guido Kroemer, Beth Levine, Eeva-Liisa Eskelinen, Fanny Mochel, Michael Spedding, Caroline Louis, Olivier R Martin, Mark J Millan
Nov 13, 2018
Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis represent a major socio-economic challenge in view of their...
Temporal separation of aggregation and ubiquitination during early inclusion formation in transgenic mice carrying the Huntington's disease mutation.
Abnormal insoluble ubiqitinated protein aggregates are found in the brains of Huntington's disease (HD) patients and in mice transgenic for the HTT mutation. Here, we describe the earliest stages of visible NII formation in...
LC3-positive structures are prominent in autophagy-deficient cells.
Gautam Runwal, Eleanna Stamatakou, Farah H Siddiqi, Claudia Puri, Ye Zhu, David C Rubinsztein
Jul 02, 2019
PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
EA Hall, MS Nahorski, LM Murray, R Shaheen, E Perkins, KN Dissanayake, Y Kristaryanto, RA Jones, J Vogt, M Rivagorda, MT Handley, GR Mali, T Quidwai, DC Soares, MA Keighren, L McKie, RL Mort, N Gammoh, A Garcia-Munoz, T Davey, M Vermeren, D Walsh, P Budd, IA Aligianis, E Faqeih, AJ Quigley, IJ Jackson, Y Kulathu, M Jackson, RR Ribchester, A von Kriegsheim, FS Alkuraya, CG Woods, ER Maher, P Mill
May 25, 2017
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