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Results: 9008
Molecular Design of Semiconducting Polymers for High-Performance Organic Electrochemical Transistors.
Christian B Nielsen, Alexander Giovannitti, Dan-Tiberiu Sbircea, Enrico Bandiello, Muhammad R Niazi, David A Hanifi, Michele Sessolo, Aram Amassian, George G Malliaras, Jonathan Rivnay, Iain McCulloch
Mar 27, 2018
The organic electrochemical transistor (OECT), capable of transducing small ionic fluxes into electronic signals in an aqueous environment, is an ideal device to utilize in bioelectronic applications. Currently, most OECTs are...
Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population.
Yanping Li, An Pan, Dong D Wang, Xiaoran Liu, Klodian Dhana, Oscar H Franco, Stephen Kaptoge, Emanuele Di Angelantonio, Meir Stampfer, Walter C Willett, Frank B Hu
May 16, 2018
BACKGROUND: Americans have a shorter life expectancy compared with residents of almost all other high-income countries. We aim to estimate the impact of lifestyle factors on premature mortality and life expectancy in the US...
Healthy lifestyle Life Expectancy Mortality Premature Adult Aged Aged 80 and over Alcohol Drinking Body Mass Index Cause of Death Databases Factual Diet Healthy Exercise Female Health Personnel health status Healthy lifestyle Humans Life Expectancy Male Middle Aged Non-Smokers Nurses Nutrition Surveys Protective factors Risk Factors Risk Reduction Behavior Time Factors United States
The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders.
Timothy Rittman, Boyd C Ghosh, Peter McColgan, David P Breen, Jonathan Evans, Caroline H Williams-Gray, Roger A Barker, James B Rowe
May 16, 2018
OBJECTIVE: Differentiating idiopathic Parkinson's disease from atypical parkinsonian syndromes is challenging, especially in the early stages. We assessed whether the Revised Addenbrooke's Cognitive Examination (ACE-R) could...
Rapid clearance of Schistosoma mansoni circulating cathodic antigen after treatment shown by urine strip tests in a Ugandan fishing community - Relevance for monitoring treatment efficacy and re-infection.
Anna O Kildemoes, Birgitte J Vennervald, Edridah M Tukahebwa, Narcis B Kabatereine, Pascal Magnussen, Claudia J de Dood, André M Deelder, Shona Wilson, Govert J van Dam
Jan 24, 2018
UNLABELLED: Schistosomiasis control and elimination has priority in public health agendas in several sub-Saharan countries. However, achieving these goals remains a substantial challenge. In order to assess progress of...
Adolescent Adult Aged Animals Anthelmintics Antigens Helminth Child Cohort Studies Cross-Sectional Studies Feces Female Humans Longitudinal Studies Male Middle Aged Praziquantel Reagent Strips Schistosoma mansoni Schistosomiasis mansoni Sensitivity and Specificity Single-Blind Method Uganda Young Adult
Disseminated $\textit{Mycobacterium malmoense}$ and $\textit{Salmonella}$ Infections Associated with a Novel Variant in $\textit{NFKBIA}$
E Staples, B Morillo-Gutierrez, J Davies, D Petersheim, M Massaad, M Slatter, D Dimou, R Doffinger, S Hackett, D Kumararatne, J Hadfield, MD Eldridge, RS Geha, M Abinun, JED Thaventhiran
May 05, 2017
JEDT is supported by a MRC Clinician Scientist Fellowship (MR/L006197/1). This work has been funded by BRC III PPG funding and by grant number 1R21AI124101-01 “Mechanisms of disease in patients with IκBα mutations” in RG’s...
Pilot Randomised Controlled Trial of a Web-Based Intervention to Promote Healthy Eating, Physical Activity and Meaningful Social Connections Compared with Usual Care Control in People of Retirement Age Recruited from Workplaces
J Lara, N O'Brien, A Godfrey, B Heaven, EH Evans, S Lloyd, S Moffatt, PJ Moynihan, TD Meyer, L Rochester, FF Sniehotta, M White, JC Mathers
Apr 07, 2017
Huntington's disease
Thomas B Stoker, Sarah L Mason, Julia C Greenland, Simon T Holden, Helen Santini, Roger A Barker
Jul 15, 2021
Huntington's disease (HD) is an inherited neurodegenerative disease characterised by neuropsychiatric symptoms, a movement disorder (most commonly choreiform) and progressive cognitive impairment. The diagnosis is usually...
Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters
Ashraf Zarkan, Marta Matuszewska, Stephen B. Trigg, Meng Zhang, Daaniyah Belgami, Cameron Croft, Junyan Liu, Sawssen El-Ouisi, Jack Greenhalgh, James S. Duboff, Taufiq Rahman, David K. Summers
Jul 28, 2021
Abstract: Persisters are a sub-population of genetically sensitive bacteria that survive antibiotic treatment by entering a dormant state. The emergence of persisters from dormancy after antibiotic withdrawal leads to recurrent...
Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden.
X Castro Dopico, S Muschiol, M Christian, L Hanke, DJ Sheward, NF Grinberg, J Rorbach, G Bogdanovic, GM Mcinerney, T Allander, C Wallace, B Murrell, J Albert, GB Karlsson Hedestam
Oct 15, 2021
covid-19 SARS-CoV-2 Sweden antibody testing population immunity serology Seroprevalence Adult Antibodies Neutralizing Antibodies Viral Blood Donors covid-19 Cross-Sectional Studies Female Humans Immunoglobulin G Male Pandemics Pregnancy Pregnancy Complications Infectious Prospective Studies SARS-CoV-2 Seroepidemiologic Studies Spike Glycoprotein Coronavirus Sweden Young Adult
Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry.
Lasse Staby, Katherine R Kemplen, Amelie Stein, Michael Ploug, Jane Clarke, Karen Skriver, Pétur O Heidarsson, Birthe B Kragelund
Sep 16, 2021
EF-hand Frequenin IDP NCS-1 Order–disorder interplay Protein Folding Amino Acid Sequence Binding Sites Carrier Proteins Humans Hydrophobic and Hydrophilic Interactions Intrinsically Disordered Proteins Kinetics Ligands Models Molecular Mutation Neuronal Calcium-Sensor Proteins Neuropeptides Protein Domains Protein Stability Thermodynamics
The role of the amygdala during emotional processing in Huntington's disease
Sarah L Mason, Jiaxiang Zhang, Faye Begeti, Natalie Valle Guzman, Alpar S Lazar, James B Rowe, Roger A Barker, Adam Hampshire
May 12, 2015
Amygdala Effective connectivity Reading the mind in the eyes Theory of mind fMRI Adult Age of Onset Amygdala Asymptomatic Diseases Brain Mapping Cognition Emotions Facial Expression Female Humans Huntington Disease Image Processing Computer-Assisted Male Mental Status Schedule Middle Aged Neural Pathways Neuropsychological Tests Oxygen Photic Stimulation Reaction Time Theory of mind
An analysis of dislocation of the domed Oxford Lateral Unicompartmental Knee Replacement
J. S. Weston-Simons, B. J. L. Kendrick, M. J. A. Mentink, H Pandit, H. S. Gill, D W Murray
Jan 01, 2014
BACKGROUND: The Oxford Unicompartmental Knee Replacement (OUKR) uses a mobile bearing to minimise wear. Bearing dislocation is a problem in the lateral compartment as the ligaments are loose in flexion. A domed tibial component...
Mathematical models of skin permeability
S Mitragotri, Y G Anissimov, A L Bunge, H F Frasch, Richard H Guy, J Hadgraft, G B Kasting, M E Lane, M S Roberts
Oct 10, 2011
Mathematical models of skin permeability play an important role in various fields including prediction of transdermal drug delivery and assessment of dermal exposure to industrial chemicals. Extensive research has been performed...
Manipulation of particles in two dimensions using phase controllable ultrasonic standing waves
Charles R. P. Courtney, C.- K. Ong, B. W. Drinkwater, A. L. Bernassau, P. D. Wilcox, D. R. S. Cumming
Feb 08, 2012
The ability to manipulate dense micrometre-scale objects in fluids is of interest to biosciences with a view to improving analysis techniques and enabling tissue engineering. A method of trapping micrometre-scale particles and...
Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
B Lo, ADE Swafford, KA Shafer-Weaver, LF Jerome, L Rakhlin, DR Mathern, CA Callahan, P Jiang, LJ Davison, HE Stevens, CL Lucas, J White, R von Borstel, JA Todd, MJ Lenardo
Feb 21, 2012
Clinical Research Prevention Autoimmune Disease Diabetes 4.2 Evaluation of markers and technologies 4.1 Discovery and preclinical testing of markers and technologies 4 Detection screening and diagnosis Metabolic and endocrine Animals Autoantibodies Diabetes mellitus Type 1 Disease Progression Electrochemistry Female Humans Insulin Antibodies Insulin-Secreting Cells Luminescent Measurements Mice Mice Inbred NOD ROC Curve Radioligand Assay Reproducibility of Results Sensitivity and Specificity
Structure and triclustering in Ba-Al-O glass
Glass-forming ability in the (BaO) x(Al 2O 3) 1-x system (0≤x≤1) was investigated by using the containerless aerodynamic levitation and laser-heating method. The main glass-forming region was found to occur for 0.40(2) ≤x≤...
Effect of Thyroid Hormone Concentration on the Transcriptional Response Underlying Induced Metamorphosis in the Mexican Axolotl (Ambystoma)
Background: Thyroid hormones (TH) induce gene expression programs that orchestrate amphibian metamorphosis. In contrast to anurans, many salamanders do not undergo metamorphosis in nature. However, they can be induced to undergo...
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