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Deconstructing a Hermeneutic Presupposition in Ricoeur’s The Symbolism of Evil
Hernán Martínez Millán
Mar 23, 2016
This paper critically analyzes Paul Ricoeurʼs presupposition that Plato’s philosophy was built on Orphism. In order to shed light on this central problematic issue in The Symbolism of Evil, this paper develops the following...
Published by: Memorial University of Newfoundland
Deconstructing a Hermeneutic Presupposition in Ricoeur’s The Symbolism of Evil
Hernán Martínez Millán
Mar 23, 2016
This paper critically analyzes Paul Ricoeurʼs presupposition that Plato’s philosophy was built on Orphism. In order to shed light on this central problematic issue in The Symbolism of Evil, this paper develops the following...
Published by: Memorial University of Newfoundland
Neural Population Dynamics Underlying Encoding of Time in the Cortico-Striatal Circuit
Francisca Martínez Traub
Jan 01, 0001
Interval timing, the ability to accurately measure elapsed time between events, is critical for generating appropriate behavioral responses. Research conducted over the past decades has implicated the cortico-striatal-thalamic...
Published by: Rockefeller University
Towards robust design of thin film transition edge sensors for use in the next-generation superconducting radio frequency cavities
Alexander Lunt, Zsolt Kovács, Hernán Furci, Torsten Koettig, Floriane Léaux, Giovanna Vandoni
May 15, 2017
In order to increase the accelerating gradient, the next-generation of Superconducting Radio Frequency (SRF) cavities will be operated with superfluid helium cooling. This upgrade requires the development of a...
Cryogenic temperature mapping Large Hadron Collider scanning electron microscopy Superconducting radio frequency cavities thin films Transition edge sensor /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Macromolecular ab initio phasing enforcing secondary and tertiary structure.
Ab initio phasing of macromolecular structures, from the native intensities alone with no experimental phase information or previous particular structural knowledge, has been the object of a long quest, limited by two main...
Structure of a 13-fold superhelix (almost) determined from first principles.
Nuclear hormone receptors are cytoplasm-based transcription factors that bind a ligand, translate to the nucleus and initiate gene transcription in complex with a co-activator such as TIF2 (transcriptional intermediary factor...
G-quadruplexes are transcription factor binding hubs in human chromatin
Jochen Spiegel, Sergio Martínez Cuesta, Santosh Adhikari, Robert Hänsel-Hertsch, David Tannahill, Shankar Balasubramanian
Apr 23, 2021
Abstract: Background: The binding of transcription factors (TF) to genomic targets is critical in the regulation of gene expression. Short, double-stranded DNA sequence motifs are routinely implicated in TF recruitment, but many...
Posttranslational Chemical Mutagenesis
The field of chemical site-selective modification of proteins has progressed extensively in recent decades to enable protein functionalization for imaging, drug delivery, and functional studies. In this Perspective, we provide...
Likelihood-based docking of models into cryo-EM maps.
Optimized docking of models into cryo-EM maps requires exploiting an understanding of the signal expected in the data to minimize the calculation time while maintaining sufficient signal. The likelihood-based rotation function...
Likelihood-based signal and noise analysis for docking of models into cryo-EM maps.
Fast, reliable docking of models into cryo-EM maps requires understanding of the errors in the maps and the models. Likelihood-based approaches to errors have proven to be powerful and adaptable in experimental structural...
G-quadruplexes are transcription factor binding hubs in human chromatin.
Jochen Spiegel, Sergio Martínez Cuesta, Santosh Adhikari, Robert Hänsel-Hertsch, David Tannahill, Shankar Balasubramanian
Mar 26, 2021
ALIXE
Fragment-based molecular replacement exploits the use of very accurate yet incomplete search models. In the case of the ARCIMBOLDO programs, consistent phase sets produced from the placement and refinement of fragments with...
Likelihood-based signal and noise analysis for docking of models into cryo-EM maps.
Fast, reliable docking of models into cryo-EM maps requires understanding of the errors in the maps and the models. Likelihood-based approaches to errors have proven to be powerful and adaptable in experimental structural...
Missing the missing values
Abstract: Nowadays, there is an increasing concern in machine learning about the causes underlying unfair decision making, that is, algorithmic decisions discriminating some groups over others, especially with groups that are...
Likelihood-based docking of models into cryo-EM maps.
Optimized docking of models into cryo-EM maps requires exploiting an understanding of the signal expected in the data to minimize the calculation time while maintaining sufficient signal. The likelihood-based rotation function...
WarpPINN
Pablo Arratia López, Hernán Mella, Sergio Uribe, Daniel E. Hurtado, Francisco Sahli Costabal
Oct 31, 2023
The diagnosis of heart failure usually includes a global functional assessment, such as ejection fraction measured by magnetic resonance imaging. However, these metrics have low discriminate power to distinguish different...
Cardiac mechanics Cardiac strain image registration physics-informed neural networks /dk/atira/pure/subjectarea/asjc/3600/3614 name=Radiological and Ultrasound Technology /dk/atira/pure/subjectarea/asjc/2700/2741 name=Radiology Nuclear Medicine and imaging /dk/atira/pure/subjectarea/asjc/1700/1707 name=Computer Vision and Pattern Recognition /dk/atira/pure/subjectarea/asjc/2700/2718 name=Health Informatics /dk/atira/pure/subjectarea/asjc/1700/1704 name=Computer Graphics and Computer-Aided Design
The antidiabetic drug lobeglitazone has the potential to inhibit PTP1B activity.
Ruth F Rocha, Tiago Rodrigues, Angela CO Menegatti, Gonçalo JL Bernardes, Hernán Terenzi
May 12, 2020
Protein tyrosine phosphatase 1B (PTP1B) is considered a potential therapeutic target for the treatment of type 2 diabetes mellitus (T2DM), since this enzyme plays a significant role to down-regulate insulin and leptin signalling...
Crystallization processes in bi-component thin film depositions:
The kinetic Monte Carlo (KMC) method is a powerful and simple tool to simulate the growth of thin films by deposition. However, one of its major drawbacks is the artificial order induced by the use of regular lattices. An...
Crystallization kinetic Monte Carlo Nanocomposite Polycrystal Thin film deposition /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/3100/3110 name=Surfaces and Interfaces
WarpPINN
Pablo Arratia López, Hernán Mella, Sergio Uribe, Daniel E. Hurtado, Francisco Sahli Costabal
Oct 31, 2023
The diagnosis of heart failure usually includes a global functional assessment, such as ejection fraction measured by magnetic resonance imaging. However, these metrics have low discriminate power to distinguish different...
Cardiac mechanics Cardiac strain image registration physics-informed neural networks /dk/atira/pure/subjectarea/asjc/3600/3614 name=Radiological and Ultrasound Technology /dk/atira/pure/subjectarea/asjc/2700/2741 name=Radiology Nuclear Medicine and imaging /dk/atira/pure/subjectarea/asjc/1700/1707 name=Computer Vision and Pattern Recognition /dk/atira/pure/subjectarea/asjc/2700/2718 name=Health Informatics /dk/atira/pure/subjectarea/asjc/1700/1704 name=Computer Graphics and Computer-Aided Design
ALEPH
Ana Medina, Josep Triviño, Rafael J Borges, Claudia Millán, Isabel Usón, Massimo D Sammito
Apr 05, 2020
The analysis of large structural databases reveals general features and relationships among proteins, providing useful insight. A different approach is required to characterize ubiquitous secondary-structure elements, where...
Putting AlphaFold models to work with phenix.process_predicted_model and ISOLDE.
Robert D Oeffner, Tristan I Croll, Claudia Millán, Billy K Poon, Christopher J Schlicksup, Randy J Read, Tom C Terwilliger
Oct 27, 2022
AlphaFold has recently become an important tool in providing models for experimental structure determination by X-ray crystallography and cryo-EM. Large parts of the predicted models typically approach the accuracy of...
Towards robust design of thin film transition edge sensors for use in the next-generation superconducting radio frequency cavities
Alexander Lunt, Zsolt Kovács, Hernán Furci, Torsten Koettig, Floriane Léaux, Giovanna Vandoni
May 15, 2017
In order to increase the accelerating gradient, the next-generation of Superconducting Radio Frequency (SRF) cavities will be operated with superfluid helium cooling. This upgrade requires the development of a...
Cryogenic temperature mapping Large Hadron Collider scanning electron microscopy Superconducting radio frequency cavities thin films Transition edge sensor /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2211 name=Mechanics of Materials /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering
Crystallization processes in bi-component thin film depositions:
The kinetic Monte Carlo (KMC) method is a powerful and simple tool to simulate the growth of thin films by deposition. However, one of its major drawbacks is the artificial order induced by the use of regular lattices. An...
Crystallization kinetic Monte Carlo Nanocomposite Polycrystal Thin film deposition /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/3100/3110 name=Surfaces and Interfaces
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