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An Artificial Bee Colony Algorithm for the Multidimensional Knapsack Problem
The Multidimensional Knapsack Problem (MDKP) stands as a prominent challenge in combinatorial optimization, with diverse applications across various domains. The Artificial Bee Colony (ABC) algorithm is a swarm intelligence...
Published by: IGI Global Scientific Publishing
Genetic versus Non-Genetic Regulation of miR-103, miR-143 and miR-483-3p Expression in Adipose Tissue and Their Metabolic Implications-A Twin Study.
Jette Bork-Jensen, Anne Cathrine Baun Thuesen, Claus Heiner Bang-Bertelsen, Louise Groth Grunnet, Flemming Pociot, Henning Beck-Nielsen, Susan E Ozanne, Pernille Poulsen, Allan Vaag
Aug 12, 2020
Murine models suggest that the microRNAs miR-103 and miR-143 may play central roles in the regulation of subcutaneous adipose tissue (SAT) and development of type 2 diabetes (T2D). The microRNA miR-483-3p may reduce adipose...
Role of VHL, HIF1A and SDH on the expression of miR-210
A Merlo, C Bernardo-Castiñeira, I Sáenz-de-Santa-María, AS Pitiot, M Balbín, A Astudillo, N Valdés, B Scola, R Del Toro, S Mendez-Ferrer, JI Piruat, C Suarez, M-D Chiara
Aug 16, 2017
The hypoxia-inducible factor 1α (HIF-1α) and its microRNA target, miR-210, are candidate tumor-drivers of metabolic reprogramming in cancer. Neuroendocrine neoplasms such as paragangliomas (PGLs) are particularly appealing for...
The miR-144/451 locus is required for erythroid homeostasis.
Kasper D Rasmussen, Salvatore Simmini, Cei Abreu-Goodger, Nenad Bartonicek, Monica Di Giacomo, Daniel Bilbao-Cortes, Rastislav Horos, Marieke von Lindern, Anton J Enright, Dónal O'Carroll
Jan 23, 2018
The process of erythropoiesis must be efficient and robust to supply the organism with red bloods cells both under condition of homeostasis and stress. The microRNA (miRNA) pathway was recently shown to regulate erythroid...
Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD
Raphael Schneider, Paul McKeever, TaeHyung Kim, Caroline Graff, John Cornelis van Swieten, Anna Karydas, Adam Boxer, Howie Rosen, Bruce L Miller, Robert Laforce, Daniela Galimberti, Mario Masellis, Barbara Borroni, Zhaolei Zhang, Lorne Zinman, Jonathan Daniel Rohrer, Maria Carmela Tartaglia, Janice Robertson, Genetic FTD Initiative (GENFI)
May 10, 2018
OBJECTIVE: To determine whether exosomal microRNAs (miRNAs) in cerebrospinal fluid (CSF) of patients with frontotemporal dementia (FTD) can serve as diagnostic biomarkers, we assessed miRNA expression in the Genetic...
MiR-221 influences effector functions and actin cytoskeleton in mast cells.
Ramon J Mayoral, Lorenzo Deho, Nicole Rusca, Nenad Bartonicek, Harpreet Kaur Saini, Anton J Enright, Silvia Monticelli
Jan 23, 2018
Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost...
3T3 Cells Actin Cytoskeleton Actins Animals Base Sequence Bone Marrow Cells Cell Adhesion Cell Degranulation Cell Differentiation Cell Movement Cell Proliferation Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation FIBROBLASTS Gene Knockdown Techniques Lentivirus Mast Cells Mice Mice Inbred C57BL MicroRNAs Molecular Sequence Data Oligonucleotide Array Sequence Analysis Up-Regulation
Exploring regulatory networks of miR-96 in the developing inner ear.
Morag A Lewis, Annalisa Buniello, Jennifer M Hilton, Fei Zhu, William I Zhang, Stephanie Evans, Stijn van Dongen, Anton J Enright, Karen P Steel
Jan 22, 2018
Mutations in the microRNA Mir96 cause deafness in mice and humans. In the diminuendo mouse, which carries a single base pair change in the seed region of miR-96, the sensory hair cells crucial for hearing fail to develop fully...
Decreased expression of miR-29 family associated with autoimmune myasthenia gravis.
Mélanie A Cron, Cloé A Payet, Odessa-Maud Fayet, Solène Maillard, Frédérique Truffault, Elie Fadel, Julien Guihaire, Sonia Berrih-Aknin, Adrian Liston, Rozen Le Panse
Dec 14, 2020
BACKGROUND: Myasthenia gravis (MG) is a rare autoimmune disease mainly mediated by autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular junction. The thymus is the effector organ, and its removal...
BAFF DICER Experimental autoimmune myasthenia gravis Interferon-β Th17 Cells Thymic epithelial cells Thymus MicroRNAs Adolescent Adult Animals Autoantibodies Cells Cultured Female Gene Expression Humans Male Mice Mice Inbred C57BL Mice Knockout MicroRNAs myasthenia gravis myasthenia gravis Autoimmune Experimental Receptors Cholinergic Thymus Gland Young Adult
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Aug 14, 2019
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral...
Animals CD8-Positive T-Lymphocytes Cell Proliferation Flow Cytometry Gene Expression Profiling Gene Regulatory Networks Immunoblotting Immunologic Memory Interferon Regulatory Factor-7 Interferons Mice Mice Inbred C57BL Mice Knockout MicroRNAs Oligonucleotide Array Sequence Analysis Orthomyxoviridae Orthomyxoviridae Infections RNA Interference Reverse Transcriptase Polymerase Chain Reaction STAT1 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins
A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis
Jong Min Lee, Kyoung Won Cho, Eun Jung Kim, Qinghuang Tang, Kye Seong Kim, Cheryll Tickle, Han Sung Jung
Sep 01, 2015
MicroRNAs are differentially expressed in breast cancer cells and have been implicated in cancer formation, tumour invasion and metastasis. We investigated the miRNA expression profiles in the developing mammary gland....
miR-1-5p targets TGF-βR1 and is suppressed in the hypertrophying hearts of rats with pulmonary arterial hypertension.
Martin Connolly, Benjamin E Garfield, Alexi Crosby, Nick W Morrell, Stephen J Wort, Paul R Kemp
Mar 31, 2020
The microRNA miR-1 is an important regulator of muscle phenotype including cardiac muscle. Down-regulation of miR-1 has been shown to occur in left ventricular hypertrophy but its contribution to right ventricular hypertrophy in...
Published by: PLOS ONE
Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.
Martin M Fabani, Cei Abreu-Goodger, Donna Williams, Paul A Lyons, Adrian G Torres, Kenneth GC Smith, Anton J Enright, Michael J Gait, Elena Vigorito
Nov 16, 2017
MicroRNAs (miRNAs) play an important role in diverse physiological processes and are potential therapeutic agents. Synthetic oligonucleotides (ONs) of different chemistries have proven successful for blocking miRNA expression....
The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation.
Dong Lu, Rinako Nakagawa, Sandra Lazzaro, Philipp Staudacher, Cei Abreu-Goodger, Tom Henley, Sara Boiani, Rebecca Leyland, Alison Galloway, Simon Andrews, Geoffrey Butcher, Stephen L Nutt, Martin Turner, Elena Vigorito
Jul 19, 2018
A single microRNA (miRNA) can regulate the expression of many genes, though the level of repression imparted on any given target is generally low. How then is the selective pressure for a single miRNA/target interaction...
3' Untranslated Regions Animals Antibody Formation B-Lymphocytes Base Sequence Binding Sites Cell Adhesion Cell Communication Cell Differentiation Gene Expression Regulation Lymphocyte Activation lymphopoiesis Mice Mice Knockout MicroRNAs Myelopoiesis PAX5 Transcription Factor Positive Regulatory Domain I-Binding Factor 1 Proto-Oncogene Proteins T-Lymphocytes Trans-Activators Transcription Factors
miR-221 affects multiple cancer pathways by modulating the level of hundreds messenger RNAs.
Laura Lupini, Cristian Bassi, Manuela Ferracin, Nenad Bartonicek, Lucilla D'Abundo, Barbara Zagatti, Elisa Callegari, Gentian Musa, Farzaneh Moshiri, Laura Gramantieri, Fernando J Corrales, Anton J Enright, Silvia Sabbioni, Massimo Negrini
Jan 23, 2018
microRNA miR-221 is frequently over-expressed in a variety of human neoplasms. Aim of this study was to identify new miR-221 gene targets to improve our understanding on the molecular tumor-promoting mechanisms affected by...
miR-1-5p targets TGF-βR1 and is suppressed in the hypertrophying hearts of rats with pulmonary arterial hypertension.
Martin Connolly, Benjamin E Garfield, Alexi Crosby, Nick W Morrell, Stephen J Wort, Paul R Kemp
Apr 27, 2020
The microRNA miR-1 is an important regulator of muscle phenotype including cardiac muscle. Down-regulation of miR-1 has been shown to occur in left ventricular hypertrophy but its contribution to right ventricular hypertrophy in...
Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark
Juliana de Almeida-Faria, Daniella E. Duque-Guimarães, Thomas P. Ong, Lucas C. Pantaleão, Asha A. Carpenter, Elena Loche, Laura C. Kusinski, Thomas J. Ashmore, Robin Antrobus, Martin Bushell, Denise S. Fernandez-Twinn, Susan E. Ozanne
Mar 08, 2021
Abstract: Aims/hypothesis: Levels of the microRNA (miRNA) miR-126-3p are programmed cell-autonomously in visceral adipose tissue of adult offspring born to obese female C57BL/6J mice. The spectrum of miR-126-3p targets and thus...
miR-155 induction is a marker of murine norovirus infection but does not contribute to control of replication in vivo.
Background: Due to their role in fine-tuning cellular protein expression, microRNAs both promote viral replication and contribute to antiviral responses, for a range of viruses. The interactions between norovirus and the...
Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson's disease patients.
Elisa Zago, Alessandra Dal Molin, Giovanna Maria Dimitri, Luciano Xumerle, Chiara Pirazzini, Maria Giulia Bacalini, Maria Giovanna Maturo, Tiago Azevedo, Simeon Spasov, Pilar Gómez-Garre, María Teresa Periñán, Silvia Jesús, Luca Baldelli, Luisa Sambati, Giovanna Calandra-Buonaura, Paolo Garagnani, Federica Provini, Pietro Cortelli, Pablo Mir, Claudia Trenkwalder, Brit Mollenhauer, Claudio Franceschi, Pietro Liò, Christine Nardini, PROPAG-AGEING consortium
Jan 28, 2022
Advanced age represents one of the major risk factors for Parkinson's Disease. Recent biomedical studies posit a role for microRNAs, also known to be remodelled during ageing. However, the relationship between microRNA...
miR-1-5p targets TGF-βR1 and is suppressed in the hypertrophying hearts of rats with pulmonary arterial hypertension
Martin Connolly, Benjamin E. Garfield, Alexi Crosby, Nick W. Morrell, Stephen J. Wort, Paul R. Kemp
Feb 28, 2020
The microRNA miR-1 is an important regulator of muscle phenotype including cardiac muscle. Down-regulation of miR-1 has been shown to occur in left ventricular hypertrophy but its contribution to right ventricular hypertrophy in...
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3.
Violeta Heras, Susana Sangiao-Alvarellos, Maria Manfredi-Lozano, María J Sanchez-Tapia, Francisco Ruiz-Pino, Juan Roa, Maribel Lara-Chica, Rosario Morrugares-Carmona, Nathalie Jouy, Ana P Abreu, Vincent Prevot, Denise Belsham, Maria J Vazquez, Marco A Calzado, Leonor Pinilla, Francisco Gaytan, Ana C Latronico, Ursula B Kaiser, Juan M Castellano, Manuel Tena-Sempere
Jan 20, 2020
Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; yet, the molecular...
A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis
Jong Min Lee, Kyoung Won Cho, Eun Jung Kim, Qinghuang Tang, Kye Seong Kim, Cheryll Tickle, Han Sung Jung
Sep 01, 2015
MicroRNAs are differentially expressed in breast cancer cells and have been implicated in cancer formation, tumour invasion and metastasis. We investigated the miRNA expression profiles in the developing mammary gland....
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy.
Camilla Nehammer, Patrick Ejlerskov, Sandeep Gopal, Ava Handley, Leelee Ng, Pedro Moreira, Huikyong Lee, Shohreh Issazadeh-Navikas, David C Rubinsztein, Roger Pocock
Dec 10, 2019
Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates that detrimentally affect cellular function and organismal survival....
C. elegans Autophagy Biochemistry chemical biology Genetics Genomics human cells mammalian cells microRNA protein aggregation 3' Untranslated Regions Animals Autophagy Base Sequence Caenorhabditis elegans Caenorhabditis elegans Proteins GTPase-Activating Proteins HeLa Cells Humans Huntingtin Protein Interferon-beta Mice MicroRNAs Mutant Proteins Peptides Protein Aggregates RNA Messenger rab GTP-Binding Proteins rab7 GTP-Binding Proteins
Deciphering the role of miR-71 in Echinococcus multilocularis early development in vitro.
Matías Gastón Pérez, Markus Spiliotis, Natalia Rego, Natalia Macchiaroli, Laura Kamenetzky, Nancy Holroyd, Marcela Alejandra Cucher, Klaus Brehm, Mara Cecilia Rosenzvit
Jan 13, 2020
Echinococcosis represents a major public health problem worldwide and is considered a neglected disease by the World Health Organization. The etiological agents are Echinococcus tapeworms, which display elaborate developmental...
MiR-211 is essential for adult cone photoreceptor maintenance and visual function.
Sara Barbato, Elena Marrocco, Daniela Intartaglia, Mariateresa Pizzo, Sabrina Asteriti, Federica Naso, Danila Falanga, Rajeshwari S Bhat, Nicola Meola, Annamaria Carissimo, Marianthi Karali, Haydn M Prosser, Lorenzo Cangiano, Enrico Maria Surace, Sandro Banfi, Ivan Conte
Apr 20, 2018
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that play an important role in the control of fundamental biological processes in both physiological and pathological conditions. Their function in...
miR-322-5p targets IGF-1 and is suppressed in the heart of rats with pulmonary hypertension.
Martin Connolly, Benjamin E Garfield, Alexi Crosby, Nick W Morrell, Stephen J Wort, Paul R Kemp
Jun 20, 2018
Pulmonary arterial hypertension (PAH) is characterised by remodelling of the pulmonary vasculature leading to right ventricular hypertrophy. Here, we show that miR-322-5p (the rodent orthologue of miR-424-5p) expression is...
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