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Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
A Saini, AR Norman, D Cunningham, I Chau, M Hill, D Tait, T Hickish, T Iveson, F Lofts, D Jodrell, PJ Ross, J Oates
Sep 02, 2020
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic...
Anti-Epidemic Policies, FTA Digital Trade Rules, and China's Digital Product Exports
This paper investigates the interactiveness of digital trade rules and anti-epidemic policies on China's digital product export. Using monthly data across 241 products from 187 countries from January 2018 to December 2021, the...
Published by: IGI Global Scientific Publishing
Secondary Metabolites of Osmanthus fragrans
Chen-Chen Fu, Fa-Ying Xu, Yu-Chen Qian, Hoi-Lun Koo, Yi-Fan Duan, Geng-Min Weng, Tai-Ping Fan, Mo-Xian Chen, Fu-Yuan Zhu
Aug 01, 2022
Osmanthus fragrans (scientific name: Osmanthus fragrans (Thunb.) Lour.) is a species of the Osmanthus genus in the family Oleaceae, and it has a long history of cultivation in China. O. fragrans is edible and is well known for...
Enhancing Urban Traffic Flow Through Fuzzy Logic-Based Signal Light Control Optimization
Yingjie Wu
Jan 01, 2024
Urban traffic congestion is an urgent problem, which is aggravated by the fixed-time urban traffic signal control system. In order to solve this problem, optimization based on fuzzy logic provides flexibility to adapt to...
Published by: IGI Global Scientific Publishing
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
5-Fluorouracil 5-methyluridine DNA break repair NUD1 RNA methylation TRMT2A homologous recombination /dk/atira/pure/subjectarea/asjc/2700/2730 name=Oncology /dk/atira/pure/subjectarea/asjc/1300/1306 name=Cancer Research /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Intensive Imaging-based Follow-up of Surgically Treated Localised Renal Cell Carcinoma Does Not Improve Post-recurrence Survival
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel Paul Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
Dec 03, 2018
The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association...
Topical treatment of actinic keratoses in organ transplant recipients
Zeeshaan-Ul Hasan, Ikhlaaq Ahmed, Rubeta N Matin, Victoria Homer, John T Lear, Ferina Ismail, Tristan Whitmarsh, Adele C Green, Jason Thomson, Alan Milligan, Sarah Hogan, Vanessa Van-de-Velde, Liza Mitchell-Worsford, Jonathan Kentley, Claire Gaunt, Yolande Jefferson-Hulme, Sarah J Bowden, Piers Gaunt, Keith Wheatley, Charlotte M Proby, Catherine A Harwood
Jun 14, 2022
BACKGROUND: The risk of cutaneous squamous cell carcinoma (cSCC) is significantly increased in organ transplant recipients (OTRs). Clearance of actinic keratoses (AKs) is generally regarded as a surrogate biomarker for cSCC...
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
5-Fluorouracil 5-methyluridine DNA break repair NUD1 RNA methylation TRMT2A homologous recombination /dk/atira/pure/subjectarea/asjc/2700/2730 name=Oncology /dk/atira/pure/subjectarea/asjc/1300/1306 name=Cancer Research /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
A Corpus-Based Study on the Translation Style of Five English Versions of Fu Sheng Liu Ji, Vol I
Bing Zhang
Oct 31, 2022
Using a corpus approach, this article investigates the translation styles of the first chapter of Fu Sheng Liu Ji at three levels: the statistical parameters, the translation of culture-specific lexis, and readability...
Published by: IGI Global Scientific Publishing
Effect of Temperature on Metronidazole Resistance in Helicobacter pylori.
Meiliang Gong, Yingjie Han, Xuning Wang, Hongjin Tao, Fansen Meng, Baicun Hou, Benjamin B Sun, Gangshi Wang
Jun 04, 2021
Efficacy of Helicobacter pylori (H. pylori) eradication therapy has declined due to rapid rises in antibiotic resistance. We investigated how increased temperature affected H. pylori (NCTC 11637) growth and its sensitivity to...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
Bilateral Habenula deep brain stimulation for treatment-resistant depression
Chencheng Zhang, Yingying Zhang, Huichun Luo, Xinmeng Xu, Ti-Fei Yuan, Dianyou Li, Yi-Yun Cai, Hengfen Gong, Dai-Hui Peng, Yi-Ru Fang, Valerie Voon, Bomin Sun
Mar 07, 2022
Deep brain stimulation (DBS) of structures in the brain's reward system is a promising therapeutic option for patients with treatment-resistant depression (TRD). Recently, DBS of the habenula (HB) in the brain's anti-reward...
“Small, yet Beautiful”
We reconsider whether a grand multi-winner contest elicits more equilibrium effort than a collection of sub-contests. Fu and Lu (2009) employ a sequential winner-selection mechanism and find support for running a grand contest....
Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer.
Aurélie Courtin, Frances M Richards, Tashinga E Bapiro, Jo L Bramhall, Albrecht Neesse, Natalie Cook, Ben-Fillippo Krippendorff, David A Tuveson, Duncan I Jodrell
Feb 12, 2020
Capecitabine (CAP) is a 5-FU pro-drug approved for the treatment of several cancers and it is used in combination with gemcitabine (GEM) in the treatment of patients with pancreatic adenocarcinoma (PDAC). However, limited...
Animals Antineoplastic Combined Chemotherapy Protocols Capecitabine Carcinoma Pancreatic Ductal Cell Line Tumor Cytidine Deaminase Deoxycytidine Disease Models Animal Drug Screening Assays Antitumor Fluorouracil Mice Mice Transgenic Neoplasm Transplantation Pancreatic Neoplasms prodrugs Tissue Distribution Gemcitabine
Long-run marginal cost pricing based on network spare capacity
Fu-Rong Li
Jan 01, 0001
This paper proposes a novel approach for providing long-run marginal cost (LRMC) pricing in network charges. The proposed approach makes use of the unused capacity of an exiting network to reflect the cost of advancing or...
Long-run marginal cost pricing based on network spare capacity
Fu-Rong Li
Jan 01, 0001
This paper proposes a novel approach for providing long-run marginal cost (LRMC) pricing in network charges. The proposed approach makes use of the unused capacity of an exiting network to reflect the cost of advancing or...
The influence of goal-state access cost on planning during problem solving
Two problem-solving experiments investigated the relationship between planning and the cost of accessing goal-state information using the theoretical framework of the soft constraints hypothesis (Gray Fu, 2004; Gray, Simms, Fu...
Exploring the interaction between renewables and energy storage for zero-carbon electricity systems
Canbing Li, Dawei Chen, Yingjie Li, Furong Li, Ran Li, Qiuwei Wu, Xubin Liu, Juan Wei, Shengtao He, Bin Zhou, Stephen Allen
Dec 15, 2022
Many countries have set ambitious targets to achieve zero-carbon electricity systems by the Mid-21st Century. In their pathways, the renewable mix and the energy storage mix have been considered as two important facets....
Energy storages Long-term planning model Renewable energy integration Zero-carbon electricity systems /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction /dk/atira/pure/subjectarea/asjc/2100/2103 name=Fuel Technology /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2300/2310 name=Pollution /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/subjectarea/asjc/2100/2100 name=General Energy /dk/atira/pure/subjectarea/asjc/2300/2308 name=Management, Monitoring, Policy and Law /dk/atira/pure/subjectarea/asjc/2200/2209 name=Industrial and Manufacturing Engineering /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Long-run network pricing to facilitate users' different security preference
This paper proposes a new long-run network pricing model that can account for network users' preference for security of supply when assessing their impact on network development costs. The new model firstly classifies load at...
Unprecedented strong and reversible atomic orbital hybridization enables a highly stable Li-S battery.
The shuttle effect and excessive volume change of the sulfur cathode severely impede the industrial implementation of Li-S batteries. It is still highly challenging to find an efficient way to suppress the shuttle effect and...
Long-term Outcomes of Follow-up for Initially Localised Clear Cell Renal Cell Carcinoma
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel P Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
May 30, 2018
BACKGROUND: Optimal follow-up (FU) strategy to detect potentially curable (PC) recurrences after treatment of localised clear cell renal cell carcinoma (ccRCC) is unclear. This study retrospectively analysed a large...
How the newborn centriole becomes a mother.
The centriole is a conserved organelle in most animal cells. It is built with numerous proteins including a 9-fold symmetrical microtubule wall. Centrioles usually exist in pairs and constitute the core of the centrosome, the...
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