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Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors.
Bárbara B Sousa, Cátia Rebelo de Almeida, Ana F Barahona, Raquel Lopes, Ana Martins-Logrado, Marco Cavaco, Vera Neves, Luís AR Carvalho, Carlos Labão-Almeida, Ana R Coelho, Marta Leal Bento, Ricardo MRM Lopes, Bruno L Oliveira, Miguel ARB Castanho, Peter Neumeister, Alexander Deutsch, Gregory I Vladimer, Nikolaus Krall, Cristina João, Francisco Corzana, João D Seixas, Rita Fior, Gonçalo JL Bernardes
Nov 15, 2022
Bruton's tyrosine kinase (BTK) is a member of the TEC-family kinases and crucial for the proliferation and differentiation of B-cells. We evaluated the therapeutic potential of a covalent inhibitor (JS25) with nanomolar potency...
Information extraction in emergency management missions
Abstract: With increasing demands for autonomous agents to work alongside
humans in emergency management response (EMR), considerations of
translations of human to machine language (and the converse) are timely....
humans in emergency management response (EMR), considerations of
translations of human to machine language (and the converse) are timely....
Information extraction in emergency management missions
Abstract: With increasing demands for autonomous agents to work alongside
humans in emergency management response (EMR), considerations of
translations of human to machine language (and the converse) are timely....
humans in emergency management response (EMR), considerations of
translations of human to machine language (and the converse) are timely....
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Juan Garrido-Maraver, Ivana Celardo, Ana C Costa, Susann Lehmann, Samantha HY Loh, L Miguel Martins
Feb 27, 2019
Exploring the emergence and evolution of population patterns of leisure-time physical activity through agent-based modelling.
Development of a dynamic framework to explain population patterns of leisure-time physical activity through agent-based modeling.
Despite the increasing body of evidences on the factors influencing leisure-time physical activity, our understanding of the mechanisms and interactions that lead to the formation and evolution of population patterns is still...
Presence of anti-eukaryotic initiation factor-2B, anti-RuvBL1/2 and anti-synthetase antibodies in patients with anti-nuclear antibody negative systemic sclerosis
John D Pauling, Gloria Salazar, Hui Lu, Zoe E Betteridge, Shervin Assassi, Maureen D Mayes, Neil J McHugh
Apr 01, 2018
Objectives: Autoantibodies targeting ubiquitously expressed nuclear antigens can be identified in most patients with SSc. Cytoplasmic autoantibodies (in otherwise ANA-negative sera) targeting eukaryotic initiation factor-2B...
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C. Costa, Samantha H. Y. Loh, L. Miguel Martins
Apr 29, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson’s disease caused by...
dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.
Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson's disease (PD), thought to be due to mitochondrial dysfunction. In Drosophila pink1...
Activating Transcription Factor 4 Animals Drosophila Drosophila Proteins Folic Acid Glycine Hydroxymethyltransferase Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Mutagenesis Neuroprotection Parkinson Disease Phenotype Protein Serine-Threonine Kinases RNA Interference RNA Small Interfering Ubiquitin-Protein Ligases Up-Regulation
Integrating Digital Technologies in Accounting Preservice Teacher Education
Ana Rodrigues
Jan 01, 2022
The importance of developing technological skills at the undergraduate level to form better professionals is no longer questionable, assuming a particular role in subjects as accounting education. However, it appears that...
Published by: IGI Global Scientific Publishing
Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa.
João Farela Neves, Rainer Doffinger, Gabriela Barcena-Morales, Catarina Martins, Olivier Papapietro, Vincent Plagnol, James Curtis, Marta Martins, Dinakantha Kumararatne, Ana Isabel Cordeiro, Conceição Neves, Luis Miguel Borrego, Matilda Katan, Sergey Nejentsev
Jan 09, 2019
Background: The auto-inflammation and phospholipase Cγ2 (PLCγ2)-associated antibody deficiency and immune dysregulation (APLAID) syndrome is a rare primary immunodeficiency caused by a gain-of-function mutation S707Y in the...
APLAID IL-10 IL-1b PLCγ2 auto-inflammatory syndromes cutis laxa sensorineural deafness Amino Acid Sequence Base Sequence Cutis Laxa DNA Mutational Analysis Female Hereditary Autoinflammatory Diseases Humans Immunologic Deficiency Syndromes Infant Newborn Inflammatory Bowel Diseases Male Mutation Missense Pedigree Phospholipase C gamma Sequence Homology Amino Acid
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways.
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C Costa, Samantha HY Loh, L Miguel Martins
Jul 20, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson's disease caused by...
Drosophila Drosophila protein kinase RNA (PKR)-like ER kinase (dPerk) ER stress activating transcription factor 4 (ATF4) Unfolded Protein Response Activating Transcription Factor 4 Animals Cell Cycle Proteins Computational Biology Drosophila Proteins Drosophila melanogaster Endoplasmic Reticulum Endoplasmic reticulum stress Eukaryotic Initiation Factor-2 HEAT-SHOCK PROTEINS Mitochondria Neurodegenerative Diseases Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases Proteomics Signal Transduction Transcription Factors Transcriptome Ubiquitin-Protein Ligases Unfolded Protein Response eIF-2 Kinase
Presence of anti-eukaryotic initiation factor-2B, anti-RuvBL1/2 and anti-synthetase antibodies in patients with anti-nuclear antibody negative systemic sclerosis
John D Pauling, Gloria Salazar, Hui Lu, Zoe E Betteridge, Shervin Assassi, Maureen D Mayes, Neil J McHugh
Apr 01, 2018
Objectives: Autoantibodies targeting ubiquitously expressed nuclear antigens can be identified in most patients with SSc. Cytoplasmic autoantibodies (in otherwise ANA-negative sera) targeting eukaryotic initiation factor-2B...
The Catalytic Role of Mobile Banking to Improve Financial Inclusion in Developing Countries
Financial inclusion is challenged by numerous factors that include country regulations and policies, poor infrastructure, lack of financial education and literacy, low income levels, political instability, geographical barriers...
Published by: IGI Global Scientific Publishing
Population structure, adaptation and divergence of the meadow spittlebug, Philaenus spumarius (Hemiptera, Aphrophoridae), revealed by genomic and morphological data.
Sofia G Seabra, Ana SB Rodrigues, Sara E Silva, Ana Carina Neto, Francisco Pina-Martins, Eduardo Marabuto, Vinton Thompson, Michael R Wilson, Selçuk Yurtsever, Antti Halkka, Maria Teresa Rebelo, Paulo AV Borges, José A Quartau, Chris D Jiggins, Octávio S Paulo
Jul 28, 2021
Understanding patterns of population differentiation and gene flow in insect vectors of plant diseases is crucial for the implementation of management programs of disease. We investigated morphological and genome-wide variation...
Processes of care and survival associated with treatment in specialist teenage and young adult cancer centres
Lorna A Fern, Rachel M Taylor, Julie Barber, Javier Alvarez-Galvez, Richard Feltbower, Sarah Lea, Ana Martins, Stephen Morris, Louise Hooker, Faith Gibson, Rosalind Raine, Dan P Stark, Jeremy Whelan
Apr 09, 2021
OBJECTIVE: Survival gains in teenagers and young adults (TYA) are reported to be lower than children and adults for some cancers. Place of care is implicated, influencing access to specialist TYA professionals and...
Teaching and Learning for Global Citizenship in the EFL Classroom
This chapter reports on a case study that aimed to understand how global citizenship education (GCE) can be integrated in the English as a Foreign Language (EFL) curriculum. In order to do that, the authors analyze the practicum...
Sustainable Development Education Curriculum Development and Instructional Design Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Longitudinal cohort study of the impact of specialist cancer services for teenagers and young adults on quality of life
Rachel M Taylor, Lorna A Fern, Julie Barber, Javier Alvarez-Galvez, Richard Feltbower, Sarah Lea, Ana Martins, Stephen Morris, Louise Hooker, Faith Gibson, Rosalind Raine, Dan P Stark, Jeremy Whelan
Dec 16, 2020
Nationally Known Hispanic Educator to Lecture at Winthrop
Winthrop University
Jan 01, 0001
Well-known Hispanic educator Ana Guzman will speak at Winthrop on May 4. Guzman, president of Palo Alto Community College, also served as senior advisor to the U.S. secretary of education.
Published by: Winthrop University
European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance.
Martin Aringer, Ralph Brinks, Thomas Dörner, David Daikh, Marta Mosca, Rosalind Ramsey-Goldman, Josef S Smolen, David Wofsy, Dimitrios T Boumpas, Diane L Kamen, David Jayne, R Cervera, Nathalie Costedoat-Chalumeau, Betty Diamond, Dafna D Gladman, Bevra Hahn, Falk Hiepe, Søren Jacobsen, Dinesh Khanna, Kirsten Lerstrøm, Elena Massarotti, Joseph McCune, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Matthias Schneider, Murray Urowitz, George Bertsias, Bimba F Hoyer, Nicolai Leuchten, Gabriela Schmajuk, Chiara Tani, Sara K Tedeschi, Zahi Touma, Branimir Anic, Florence Assan, Tak Mao Chan, Ann Elaine Clarke, Mary K Crow, László Czirják, Andrea Doria, Winfried Graninger, Bernadett Halda-Kiss, Sarfaraz Hasni, Peter M Izmirly, Michelle Jung, Gábor Kumánovics, Xavier Mariette, Ivan Padjen, José M Pego-Reigosa, Juanita Romero-Diaz, Íñigo Rúa-Figueroa, Raphaèle Seror, Georg H Stummvoll, Yoshiya Tanaka, Maria G Tektonidou, Carlos Vasconcelos, Edward M Vital, Daniel J Wallace, Sule Yavuz, Pier Luigi Meroni, Marvin J Fritzler, Ray Naden, Karen Costenbader, Sindhu R Johnson
Feb 12, 2021
BACKGROUND/OBJECTIVES: The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 classification criteria for systemic lupus erythematosus system showed high specificity, while attaining also high...
Internet Addiction
Different educational programs aim to reduce or control Internet addiction. These are based on a traditional methodology that can be recognized as an exposition or master class (participatory or not). In this type of educational...
Published by: IGI Global Scientific Publishing
Clinical variability of early-onset congenital myasthenic syndrome due to biallelic RAPSN mutations in Brazil.
Eduardo de Paula Estephan, Antonio Alberto Zambon, Paulo Eurípedes Marchiori, André Macedo Serafim da Silva, Vitor Marques Caldas, Cristiane Araújo Martins Moreno, Umbertina Conti Reed, Rita Horvath, Ana Töpf, Hanns Lochmüller, Edmar Zanoteli
Jan 09, 2019
Mutations in RAPSN are an important cause of congenital myasthenic syndrome (CMS), leading to endplate acetylcholine receptor deficiency. We present three RAPSN early-onset CMS patients (from a Brazilian cohort of 61 CMS...
The Post-COVID-19 E-Services Continuance Usage in Low-Income Countries
The COVID-19 pandemic renewed the role of digital government for conventional delivery of e-services while creating a paradigm shift for the telecommuting ecosystem. Prior to COVID-19, e-services usage had been slow in...
Published by: IGI Global Scientific Publishing
A Systematic Literature Review on Hospitality Analytics
With the growth of data generated by all systems involved in a hotel, terms like big data and business analytics (BA) gain strength within the hotel industry. Business analytics can be used in hospitality management to increase...
Published by: IGI Global Scientific Publishing
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