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Desgarraduras del cuerpo y degolladuras de la voz
B Epps
Aug 24, 2017
El mismo mar de todos los veranos de Esther Tusquets narra la tormentosa relación erótica y emocional de una mujer de la alta burguesía catalana, casada y desencantada, que ejerce de profesora de literatura, con una joven...
De la philosophie de la religion dans l’oeuvre de Landgrebe
Sylvain Camilleri
Apr 22, 2021
Nombreux sont les premiers disciples de Husserl à s’être intéressés de prèsà la religion. Landgrebe ne fait pas exception à la règle, même si j’entendsmontrer qu’il constitue plutôt un cas à part. Pourquoi donc ? Parce que...
Published by: Memorial University of Newfoundland
De la philosophie de la religion dans l’oeuvre de Landgrebe
Sylvain Camilleri
Apr 22, 2021
Nombreux sont les premiers disciples de Husserl à s’être intéressés de prèsà la religion. Landgrebe ne fait pas exception à la règle, même si j’entendsmontrer qu’il constitue plutôt un cas à part. Pourquoi donc ? Parce que...
Published by: Memorial University of Newfoundland
Cancer associated fibroblast FAK regulates malignant cell metabolism
Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S. H. Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E. Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A. Graham, Julie Foster, Yu Wang, James J. Campbell, Rajinder Singh, Penglie Zhang, Thomas J. Schall, Frances R. Balkwill, Jane Sosabowski, Pedro R. Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Mar 10, 2021
Abstract: Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we show that CAFs regulate malignant cell metabolism through...
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S H Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A Graham, Julie Foster, Yu Wang, James J Campbell, Rajinder Singh, Penglie Zhang, Thomas J Schall, Frances R Balkwill, Jane Sosabowski, Pedro R Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Apr 11, 2020
Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we show that CAFs regulate malignant cell metabolism through pathways...
Published by: Nature Communications
Intolerancia en Tiempos de Crisis: Hacia una Literatura Transgresora en El sitio de los sitios de Juan Goytisolo
Oscar Ivan Useche
Jan 01, 0001
Este artículo propone entender la novela de Goytisolo como una respuesta cultural a la crisis de los modelos de racionalidad occidental. Se estudian las dinámicas de descomposición social de la globalización y la aparición...
Juan Goytisolo globalization Sarajevo historical memory memoria historica globalizacion State of Siege fiction Modern Literature Spanish and Portuguese Language and Literature
Published by: Ursinus College
Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease
Gema Gómez-Mariano, Nerea Matamala, Selene Martínez, Iago Justo, Alberto Marcacuzco, Carlos Jimenez, Sara Monzón, Isabel Cuesta, Cristina Garfia, María Teresa Martínez, Meritxell Huch, Ignacio Pérez de Castro, Manuel Posada, Sabina Janciauskiene, Beatriz Martínez-Delgado
Jun 06, 2020
Abstract: Background and aims: Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of...
Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation.
A plethora of AI-based techniques now exists to conduct de novo molecule generation that can devise molecules conditioned towards a particular endpoint in the context of drug design. One popular approach is using reinforcement...
Le Diable dans la bibliothèque
Dans Thinking with Demons (1997), Stuart Clark a montré que la démonologie, cette composante essentielle de la pensée de la première modernité, n’était pas une affaire de spécialistes: ‘penser avec le diable’ était une activité...
Determinantes de la movilidad ocupacional segmentada de los inmigrantes no comunitarios en España
La literatura sobre la integración económica de los inmigrantes ha destacado la existencia de un patrón de movilidad en forma de «U». En este artículo discutimos esta argumentación partiendo de las teorías de la segmentación del...
Economic Integration of Immigrants International Migration Labor Market Segmentation Segmented Occupational Mobility Spain Anthropology Social and Cultural Anthropology Sociology
Published by: Winthrop University
Christian de Duve, 1963
The Rockefeller University
Jan 01, 0001
Christian de Duve. The separation and characterization of subcellular particles.
Lecture delivered November 21, 1963
Posted with permission
Published by: Academic Press
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana SH Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A Graham, Julie Foster, Yu Wang, James J Campbell, Rajinder Singh, Penglie Zhang, Thomas J Schall, Frances R Balkwill, Jane Sosabowski, Pedro R Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Mar 11, 2020
Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we show that CAFs regulate malignant cell metabolism through pathways...
Animals Breast Neoplasms Cancer-Associated Fibroblasts Cell Line Tumor Cell Proliferation Chemokines Female Focal Adhesion Protein-Tyrosine Kinases Glycolysis Humans Male Metabolic Networks and Pathways Mice Inbred C57BL Neoplasms Pancreatic Neoplasms Phosphoproteins Stromal Cells Survival Analysis Xenograft Model Antitumor Assays
Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation.
A plethora of AI-based techniques now exists to conduct de novo molecule generation that can devise molecules conditioned towards a particular endpoint in the context of drug design. One popular approach is using reinforcement...
Geographies of conservation I
WM ADAMS
Apr 22, 2016
© The Author(s) 2016. Extinction has long been a central concern in biodiversity conservation. Today, de-extinction offers interesting possibilities of restoring charismatic species and ecosystem function, but also risks and...
Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease.
Gema Gómez-Mariano, Nerea Matamala, Selene Martínez, Iago Justo, Alberto Marcacuzco, Carlos Jimenez, Sara Monzón, Isabel Cuesta, Cristina Garfia, María Teresa Martínez, Meritxell Huch, Ignacio Pérez de Castro, Manuel Posada, Sabina Janciauskiene, Beatriz Martínez-Delgado
Dec 12, 2020
BACKGROUND AND AIMS: Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of misfolded AAT...
De-globalisation and decoupling
P Williamson
Feb 19, 2021
It has become fashionable to argue that the post-coronavirus world will see an acceleration in de-globalisation and decoupling and that companies will substantively re-localise their supply chains (Javorcik, 2020; McKinsey...
Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor.
Simone Queiroz Pantaleão, Lívia de Moraes Bomediano Camillo, Tainan Cerqueira Neves, Isabela de Godoy Menezes, Lucas Matheus Stangherlin, Helena Beatriz de Carvalho Ruthner Batista, Emma Poole, Michael Nevels, Eric Alisson Philot, Ana Ligia Scott, Maria Cristina Carlan da Silva
Jan 04, 2023
The human cytomegalovirus (HCMV) UL111A gene encodes several homologs of the cellular interleukin 10 (cIL-10). Alternative splicing in the UL111A region produces two relatively well-characterized transcripts designated cmvIL-10...
Assessment of the effectiveness of physical activity interventions in the Brazilian Unified Health System.
Evelyn Helena Corgosinho Ribeiro, Leandro Martin Totaro Garcia, Emanuel Péricles Salvador, Evelyn Fabiana Costa, Douglas Roque Andrade, Maria do Rosario Dias de Oliveira Latorre, Alex Antonio Florindo
Sep 11, 2018
OBJECTIVE: To assess the effect of interventions on the levels of physical activity of healthy adults, users of the Brazilian Unified Health System and attended by the Family Health Strategy. METHODS: Non-randomized experimental...
The tour de France
From its initial inception in 1903 as a race premised on a publicity stunt to sell newspapers, the Tour de France had grown and evolved over time to become one of the most difficult and heralded sporting events in the world....
The tour de France
From its initial inception in 1903 as a race premised on a publicity stunt to sell newspapers, the Tour de France had grown and evolved over time to become one of the most difficult and heralded sporting events in the world....
Exceptional scalar theories in de Sitter space
Abstract
The special galileon and Dirac-Born-Infeld (DBI) theories are effective field theories of a single scalar field that have many interesting...
Efficiency and accuracy of visual search develop at different rates from early childhood through early adulthood
Abstract: Most studies of visual search across the life span have focused on classic feature and conjunction searches in which observers search for a fixed, simple shape target among relatively homogeneous distractors over a...
Exceptional scalar theories in de Sitter space
The special galileon and Dirac-Born-Infeld (DBI) theories are effective field theories of a single scalar field that have many interesting properties in flat space. These theories can be extended to all maximally symmetric...
Regular Article - Theoretical Physics Effective Field Theories global symmetries Space-Time Symmetries
Published by: Springer Berlin Heidelberg
ROBERT DARNELL AND TITIA DE LANGE
The Rockefeller University
Jan 01, 0001
Robert Darnell and Titia de Lange have been elected to the Institute of Medicine
Published by: The Rockefeller University
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