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An efficient arabinoxylan-debranching α-L-arabinofuranosidase of family GH62 from Aspergillus nidulans contains a secondary carbohydrate binding site.
Casper Wilkens, Susan Andersen, Bent O Petersen, An Li, Marta Busse-Wicher, Johnny Birch, Darrell Cockburn, Hiroyuki Nakai, Hans EM Christensen, Birthe B Kragelund, Paul Dupree, Barry McCleary, Ole Hindsgaul, Maher Abou Hachem, Birte Svensson
Mar 21, 2016
Affinity gel electrophoresis Arabinoxylan Arabinoxylooligosaccharides Glycoside hydrolase family 62 Inverting mechanism Surface binding site Arabinose Aspergillus nidulans Binding Sites Catalytic Domain Cloning Molecular Fungal Proteins Gene Expression Regulation Fungal Glycoside Hydrolases Phylogeny Pichia Polysaccharides Protein Conformation Streptomyces Substrate Specificity Triticum Xylans Xylose beta-Glucans
Population biology and phenology of the colour polymorphic damselfly
<i>Ischnura elegans</i>
at its southern range limit in Cyprus
1. Geographically widespread species provide excellent opportunities to investigate how phenotypes change across large‐scale environmental gradients. Temperature is a fundamental environmental variable and an important...
Non-stationarity in annual and seasonal series of peak flow and precipitation in the UK
When designing or maintaining an hydraulic structure, an estimate of the frequency and magnitude of extreme events is required. The most common methods to obtain such estimates rely on the assumption of stationarity, i.e. the...
Statistical distributions for monthly aggregations of precipitation and streamflow in drought indicator applications
Drought indicators are used as triggers for action and so are the foundation of drought monitoring and early warning. The computation of drought indicators like the standardized precipitation index (SPI) and standardized...
Human influences on evolution, and the ecological and societal consequences.
Computational approaches for interpreting scRNA-seq data.
The recent developments in high-throughput single-cell RNA sequencing technology (scRNA-seq) have enabled the generation of vast amounts of transcriptomic data at cellular resolution. With these advances come new modes of data...
Non-stationarity in annual and seasonal series of peak flow and precipitation in the UK
When designing or maintaining an hydraulic structure, an estimate of the frequency and magnitude of extreme events is required. The most common methods to obtain such estimates rely on the assumption of stationarity, i.e. the...
General Principles of Neuronal Co-transmission
Erik Svensson, John Apergis-Schoute, Geoffrey Burnstock, Michael P Nusbaum, David Parker, Helgi B Schiöth
Feb 08, 2019
A Review of the Segmental Diameter of the Healthy Human Spinal Cord.
Knowledge of the average size and variability of the human spinal cord can be of importance when treating pathological conditions in the spinal cord. Data on healthy human spinal cord morphometrics have been published for more...
Developing drought impact functions for drought risk management
Drought management frameworks are dependent on methods for monitoring and prediction, but quantifying the hazard alone is arguably not sufficient; the negative consequences that may arise from a lack of precipitation must also...
Fragment-Based Drug Discovery of Phosphodiesterase Inhibitors.
Phosphodiesterases are proving to be fruitful targets for drug discovery. At the same time fragment-based drug discovery has matured into a powerful and widely applied technique. In this communication we review the application...
Statistical distributions for monthly aggregations of precipitation and streamflow in drought indicator applications
Drought indicators are used as triggers for action and so are the foundation of drought monitoring and early warning. The computation of drought indicators like the standardized precipitation index (SPI) and standardized...
SpatialDE
Technological advances have made it possible to measure spatially resolved gene expression at high throughput. However, methods to analyze these data are not established. Here we describe SpatialDE, a statistical test to...
Altered GABA and somatostatin modulation of proprioceptive feedback after spinal cord injury in lamprey.
Non-stationarity in annual and seasonal series of peak flow and precipitation in the UK
When designing or maintaining an hydraulic structure, an estimate of the frequency and magnitude of extreme events is required. The most common methods to obtain such estimates rely on the assumption of stationarity, i.e. the...
Computational Chemistry on a Budget
An increasing number of new drugs have their origin in small biotech or academia. In contrast to big pharma, these environments are often more limited in terms of resources, and this necessitates different approaches to the drug...
Developing drought impact functions for drought risk management
Drought management frameworks are dependent on methods for monitoring and prediction, but quantifying the hazard alone is arguably not sufficient; the negative consequences that may arise from a lack of precipitation must also...
Hyperlinks and Copyright Infringement
DOES the posting of a hyperlink to somebody else's work that has been uploaded onto the Internet infringe their copyright? Although dissenters did exist, most copyright lawyers long assumed that the answer to that...
C Angelopoulos
May 10, 2017
Non-stationarity in annual and seasonal series of peak flow and precipitation in the UK
When designing or maintaining an hydraulic structure, an estimate of the frequency and magnitude of extreme events is required. The most common methods to obtain such estimates rely on the assumption of stationarity, i.e. the...
Assessment of Platelet Function in Traumatic Brain Injury-A Retrospective Observational Study in the Neuro-Critical Care Setting.
Caroline Lindblad, Eric Peter Thelin, Michael Nekludov, Arvid Frostell, David W Nelson, Mikael Svensson, Bo-Michael Bellander
Jun 28, 2018
BACKGROUND: Despite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI), stressing the need for new diagnostic techniques. Multiple...
Engagement of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) by receptor-interacting protein 2 (RIP2) is insufficient for signal transduction.
Caspase Death Domain Inflammation innate immunity NF-κB (NF-κB) Nod-like Receptor (NLR) Protein Kinase Protein-Protein Interaction Signal Transduction HEK293 Cells Humans Mutation Nod1 Signaling Adaptor Protein Protein Multimerization Protein Structure Secondary Protein Structure Tertiary Receptor-Interacting Protein Serine-Threonine Kinase 2 Signal Transduction
An atlas of mouse CD4(+) T cell transcriptomes.
Michael JT Stubbington, Bidesh Mahata, Valentine Svensson, Andrew Deonarine, Jesper K Nissen, Alexander G Betz, Sarah A Teichmann
May 16, 2019
BACKGROUND: CD4(+) T cells are key regulators of the adaptive immune system and can be divided into T helper (Th) cells and regulatory T (Treg) cells. During an immune response Th cells mature from a naive state into one of...
Alternative Splicing Animals Cell Differentiation Cluster Analysis Flow Cytometry Gene Expression Profiling Gene Expression Regulation Immune System Mice Mice Inbred C57BL principal component analysis Protein Isoforms RNA Messenger Sequence Analysis RNA Signal Transduction T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Th17 Cells Transcriptome Up-Regulation
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