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The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository
Jason R Taylor, Nitin Williams, Rhodri Cusack, Tibor Auer, Meredith A Shafto, Marie Dixon, Lorraine K Tyler, Cam-CAN, Richard N Henson
Feb 09, 2018
This paper describes the data repository for the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) initial study cohort. The Cam-CAN Stage 2 repository contains multi-modal (MRI, MEG, and cognitive-behavioural) data from a...
Ageing Brain imaging Cognition Data repository Magnetic Resonance Imaging Magnetoencephalography Adolescent Adult Aged Aged 80 and over aging Brain Cognition Cross-Sectional Studies Databases Factual Female Functional Neuroimaging Humans Magnetic Resonance Imaging Magnetoencephalography Male Middle Aged Neurosciences Young Adult
Adult Lifespan Cognitive Variability in the Cross-Sectional Cam-CAN Cohort.
This study examines variability across the age span in cognitive performance in a cross-sectional, population-based, adult lifespan cohort from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study (n = 2680). A key...
MMSE adult lifespan ceiling effects cognitive variability Episodic memory Heterogeneity variance confounders verbal fluency Adolescent Adult Aged Aged 80 and over Cognition Cognition Disorders Cognitive Aging Cohort Studies Confounding Factors Epidemiologic Cross-Sectional Studies Female Humans Male Memory Middle Aged Psychological Tests Young Adult
How parents choose to use CAM
BACKGROUND: Complementary and Alternative Medicine (CAM) is widely used throughout the UK and the Western world. CAM is commonly used for children and the decision-making process to use CAM is affected by numerous factors....
Age-Related Increases in Verbal Knowledge Are Not Associated With Word Finding Problems in the Cam-CAN Cohort
Objective: We tested the claim that age-related increases in knowledge interfere with word retrieval, leading to word finding failures. We did this by relating a measure of crystallized intelligence to tip-of-the-tongue (TOT)...
Published by: J Gerontol B Psychol Sci Soc Sci
How parents choose to use CAM
BACKGROUND: Complementary and Alternative Medicine (CAM) is widely used throughout the UK and the Western world. CAM is commonly used for children and the decision-making process to use CAM is affected by numerous factors....
The use of Complementary and Alternative Medicine (CAM) among Italian children
Viviana Stampini, Sara Bortoluzzi, Elias Allara, Roberta Amadori, Daniela Surico, Flavia Prodam, Francesco Barone-Adesi, Fabrizio Faggiano
Sep 25, 2019
OBJECTIVE: To examine prevalence and modalities of CAM use in children living in Novara, a northern Italian city, and to estimate the prescription rate from paediatricians. METHOD: We administered a phone questionnaire to the...
Exploring patterns of response across the lifespan
BACKGROUND: With declining rates of participation in epidemiological studies there is an important need to attempt to understand what factors might affect response. This study examines the pattern of response at different adult...
Visual short-term memory through the lifespan
Visual short-term memory ability falls throughout the lifespan in healthy adults. Using a continuous report task, in a large, population-based sample, we first confirmed that this decline affects the quality and quantity of...
A watershed model of individual differences in fluid intelligence
Fluid intelligence is a crucial cognitive ability that predicts key life outcomes across the lifespan. Strong empirical links exist between fluid intelligence and processing speed on the one hand, and white matter integrity and...
cognitive ageing Fluid intelligence Processing speed structural equation modelling Watershed model white matter Adolescent Adult Aged Aged 80 and over aging Cohort Studies Endophenotypes Factor Analysis Statistical Female Humans Individuality Intelligence Intelligence Tests Male Middle Aged Models Neurological Models Psychological Reaction Time white matter Young Adult
Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking.
Rogier A Kievit, Simon W Davis, Daniel J Mitchell, Jason R Taylor, John Duncan, Cam-CAN Research Team, Richard NA Henson, Cam-CAN Research Team
Jun 26, 2018
Ageing is characterized by declines on a variety of cognitive measures. These declines are often attributed to a general, unitary underlying cause, such as a reduction in executive function owing to atrophy of the prefrontal...
Structure of the Chicken Neuron-Glia Cell Adhesion Molecule, Ng-CAM: Origin of the Polypeptides and Relation to the Ig Superfamily
Mark P Burgoon
Jan 01, 0001
The neuron-glia cell adhesion molecule, Ng-CAM, is a cell-surface glycoprotein expressed on neurons and Schwann cells in the chicken nervous system. It is expressed as a group of related components of -200 kD, 135 kD, and 80 kD...
Published by: Rockefeller University
Characterising group-level brain connectivity
The brain can be modelled as a network with nodes and edges derived from a range of imaging modalities: the nodes correspond to spatially distinct regions and the edges to the interactions between them. Whole-brain connectivity...
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
JR Grainger, KA Smith, JP Hewitson, HJ McSorley, Y Harcus, KJ Filbey, CAM Finney, EJD Greenwood, DP Knox, MS Wilson, Y Belkaid, AY Rudensky, RM Maizels
Sep 20, 2017
Animals Antigens Helminth Benzamides Cell Proliferation Chronic Disease Dioxoles Forkhead Transcription Factors Gene Expression Regulation host-parasite interactions Mice Mice Inbred BALB C Mice Transgenic Nematospiroides dubius Phosphorylation Protein Serine-Threonine Kinases Receptor Transforming Growth Factor-beta Type II Receptors Transforming Growth Factor beta Signal Transduction Smad2 Protein Smad3 Protein Strongylida Infections T-Lymphocytes Regulatory Th1 Cells Th2 Cells Transforming Growth Factor beta
The Geology of the Middle Cam Valley, Cambridgeshire, UK
This study offers a new understanding of the stratigraphy and context of the Pleistocene (including Elsterian and Weichselian) and Holocene deposits of the Middle Cam valley, Cambridgeshire, United Kingdom, and provides...
How are age-related differences in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults.
OBJECTIVES: To examine age-related differences in self-reported sleep quality and their associations with health outcomes across four domains: physical health, cognitive health, mental health and neural health. SETTING...
Ageing Cognition Healthy ageing Mental Health physical health sleep quality white matter Adolescent Adult Age Factors Aged Aged 80 and over ANISOTROPY Bayes Theorem Cognition Female health status Humans Male Mental Health Middle Aged prevalence Sleep Sleep Wake Disorders United Kingdom white matter Young Adult
Age-Related Increases in Verbal Knowledge Are Not Associated With Word Finding Problems in the Cam-CAN Cohort
interference Knowledge Naming Tip-of-the-tongue (TOT) Word retrieval Adolescent Adult Aged Aged 80 and over Cognitive Aging Cohort Studies Female Humans Intelligence Tests Male Mental Recall Middle Aged pattern recognition Visual Phonetics Psychometrics RECOGNITION psychology Verbal Learning Young Adult
Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter.
Juho M Strömmer, Simon W Davis, Richard N Henson, Lorraine K Tyler, Cam-CAN, Karen L Campbell
Dec 18, 2018
Physical activity has positive effects on brain health and cognitive function throughout the life span. Thus far, few studies have examined the effects of physical activity on white matter microstructure and psychomotor speed...
brain aging cognitive decline Exercise Adolescent Adult Age Factors Aged Aged 80 and over aging ANISOTROPY Cognition Diffusion Magnetic Resonance Imaging England Exercise Female Frontal Lobe Humans Image Processing Computer-Assisted Male Middle Aged Psychomotor Performance Reaction Time Surveys and Questionnaires white matter
Greater lifestyle engagement is associated with better age-adjusted cognitive abilities.
G Sophia Borgeest, Richard N Henson, Meredith Shafto, David Samu, Cam-CAN, Rogier A Kievit
Jun 23, 2020
Previous evidence suggests that modifiable lifestyle factors, such as engagement in leisure activities, might slow the age-related decline of cognitive functions. Less is known, however, about which aspects of lifestyle might be...
The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol
Meredith A Shafto, Lorraine K Tyler, Marie Dixon, Jason R Taylor, James B Rowe, Rhodri Cusack, Andrew J Calder, William D Marslen-Wilson, John Duncan, Tim Dalgleish, Richard N Henson, Carol Brayne, Fiona E Matthews, Cam-CAN
Mar 17, 2015
Greater lifestyle engagement is associated with better age-adjusted cognitive abilities
G. Sophia Borgeest, Richard N. Henson, Meredith Shafto, David Samu, Cam-CAN, Rogier A. Kievit
May 21, 2020
Previous evidence suggests that modifiable lifestyle factors, such as engagement in leisure activities, might slow the age-related decline of cognitive functions. Less is known, however, about which aspects of lifestyle might be...
State and Trait Components of Functional Connectivity
Resting-state functional connectivity, as measured by functional magnetic resonance imaging (fMRI), is often treated as a trait, used, for example, to draw inferences about individual differences in cognitive function, or...
Move and Construal Examined
Michiya Kawai
Aug 01, 2013
This paper studies Hornstein's (2001) proposal that construal in natural language involves movement (construal-as-movement [CAM]), by examining the CAM analysis of tough constructions. The CAM analysis suffers because (a)...
Published by: Atlantic Provinces Linguistic Association
Alternative Medicine: All Quack and No Bite? A Conversation About Integrating Alternative Medicine Into our Healthcare System
Abigail J O'Keefe
Jan 01, 0001
Complementary and Alternative Medicine (CAM) is a burgeoning medical practice in the U.S.; nearly 40% of adults practice it in some form. CAM may resolve deficiencies in American healthcare, both in its cost and effectiveness....
CAM alternative therapies complementary medicine quacks mindfulness meditation Placebos Help-seeking Alternative and Complementary Medicine Biology Life Sciences
Published by: Ursinus College
Calmodulin binds to Drosophila TRP with an unexpected mode.
Weidi Chen, Zeyu Shen, Sabrina Asteriti, Zijing Chen, Fei Ye, Ziling Sun, Jun Wan, Craig Montell, Roger C Hardie, Wei Liu, Mingjie Zhang
Jan 05, 2021
Drosophila TRP is a calcium-permeable cation channel essential for fly visual signal transduction. During phototransduction, Ca2+ mediates both positive and negative feedback regulation on TRP channel activity, possibly via...
The Causes of High Human Development in Cuba
Cam Bortolon
Sep 11, 2018
Cuba continues to have a HDI score well above what one would expect from a country of its GDP. A unique case both regionally and globally, it presents an impressive degree of success in meeting human security needs. This paper...
Published by: Memorial University of Newfoundland
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