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Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration.
The physical continuity of axons over long cellular distances poses challenges for their maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike other intracellular organelles, this forms a...
Endoplasmic Reticulum neurodegeneration calcium stores Axonal Transport hereditary spastic paraplegia organelle contact sites smooth ER
Published by: Frontiers in neuroscience
A phagocytic route for uptake of double-stranded RNA in RNAi.
RNA interference (RNAi) has a range of physiological functions including as a defence mechanism against viruses. To protect uninfected cells in a multicellular organism, not only a cell-autonomous RNAi response is required but...
Virtual Fly Brain-An interactive atlas of the Drosophila nervous system.
Virtual Fly Brain-An interactive atlas of the Drosophila nervous system.
Robert Court, Marta Costa, Clare Pilgrim, Gillian Millburn, Alex Holmes, Alex McLachlan, Aoife Larkin, Nicolas Matentzoglu, Huseyin Kir, Helen Parkinson, Nicolas H Brown, Cahir J O'Kane, J Douglas Armstrong, Gregory SXE Jefferis, David Osumi-Sutherland
Mar 16, 2023
As a model organism, Drosophila is uniquely placed to contribute to our understanding of how brains control complex behavior. Not only does it have complex adaptive behaviors, but also a uniquely powerful genetic toolkit...
Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.
Benjamin R Underwood, Sara Imarisio, Angeleen Fleming, Claudia Rose, Gauri Krishna, Phoebe Heard, Marie Quick, Viktor I Korolchuk, Maurizio Renna, Sovan Sarkar, Moisés García-Arencibia, Cahir J O'Kane, Michael P Murphy, David C Rubinsztein
Jan 03, 2018
Many neurodegenerative diseases exhibit protein accumulation and increased oxidative stress. Therapeutic strategies include clearing aggregate-prone proteins by enhancing autophagy or decreasing oxidative stress with...
Complex inhibitory effects of nitric oxide on autophagy.
Sovan Sarkar, Viktor I Korolchuk, Maurizio Renna, Sara Imarisio, Angeleen Fleming, Andrea Williams, Moises Garcia-Arencibia, Claudia Rose, Shouqing Luo, Benjamin R Underwood, Guido Kroemer, Cahir J O'Kane, David C Rubinsztein
Jan 04, 2018
Autophagy, a major degradation process for long-lived and aggregate-prone proteins, affects various human processes, such as development, immunity, cancer, and neurodegeneration. Several autophagy regulators have been identified...
Animals Apoptosis Regulatory Proteins Autophagy Beclin-1 Cell Line Class III Phosphatidylinositol 3-Kinases Enzyme Inhibitors HEK293 Cells HeLa Cells Humans Huntingtin Protein Huntington Disease I-kappa B Kinase Mechanistic Target of Rapamycin Complex 1 Membrane Proteins Mice Mitogen-Activated Protein Kinase 8 Multiprotein Complexes NG-Nitroarginine Methyl Ester Nerve Tissue Proteins Nitric oxide nitric oxide synthase Nuclear Proteins Phosphorylation Protein Isoforms Proteins Proto-Oncogene Proteins c-bcl-2 Rats TOR Serine-Threonine Kinases Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins
PICALM modulates autophagy activity and tau accumulation.
Kevin Moreau, Angeleen Fleming, Sara Imarisio, Ana Lopez Ramirez, Jacob L Mercer, Maria Jimenez-Sanchez, Carla F Bento, Claudia Puri, Eszter Zavodszky, Farah Siddiqi, Catherine P Lavau, Maureen Betton, Cahir J O'Kane, Daniel S Wechsler, David C Rubinsztein
Oct 09, 2014
Animals Autophagy Autophagy-Related Protein 12 Cell Line Drosophila Endocytosis Female FIBROBLASTS Genome-Wide Association Study HEK293 Cells HeLa Cells Humans Male Mice Monomeric Clathrin Assembly Proteins Phagosomes Protein Binding RNA Small Interfering Risk Factors Small Ubiquitin-Related Modifier Proteins Transfection Vesicle-Associated Membrane Protein 2 Zebrafish tau Proteins
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Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration
The physical continuity of axons over long cellular distances poses challenges for their maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike other intracellular organelles, this forms a...
Mesoscopic kinetic Monte Carlo modeling of organic photovoltaic device characteristics
Measured mobility and current-voltage characteristics of single layer and photovoltaic (PV) devices composed of poly{9,9-dioctylfluorene-co-bis[N,N -(4-butylphenyl)]bis(N,N-phenyl-1,4- phenylene)diamine} (PFB) and...
Mesoscopic kinetic Monte Carlo modeling of organic photovoltaic device characteristics
Measured mobility and current-voltage characteristics of single layer and photovoltaic (PV) devices composed of poly{9,9-dioctylfluorene-co-bis[N,N -(4-butylphenyl)]bis(N,N-phenyl-1,4- phenylene)diamine} (PFB) and...
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Maria Jimenez-Sanchez, Wun Lam, Michael Hannus, Birte Sönnichsen, Sara Imarisio, Angeleen Fleming, Alessia Tarditi, Fiona Menzies, Teresa Ed Dami, Catherine Xu, Eduardo Gonzalez-Couto, Giulia Lazzeroni, Freddy Heitz, Daniela Diamanti, Luisa Massai, Venkata P Satagopam, Guido Marconi, Chiara Caramelli, Arianna Nencini, Matteo Andreini, Gian Luca Sardone, Nicola P Caradonna, Valentina Porcari, Carla Scali, Reinhard Schneider, Giuseppe Pollio, Cahir J O'Kane, Andrea Caricasole, David C Rubinsztein
Jan 10, 2018
Huntington's disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified new modifiers of mutant HTT toxicity by performing a...
Aminoacyltransferases Animals Cells Cultured Computational Biology Drosophila Drug Evaluation Preclinical Enzyme Inhibitors Green Fluorescent Proteins Humans Huntingtin Protein Huntington Disease Mice Mice Inbred C57BL Mutation Nerve Tissue Proteins Neurons RNA Small Interfering Zebrafish alpha-Crystallin B Chain
Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics
Megan K. Oliva, Juan José Pérez-Moreno, Jillian O’Shaughnessy, Trevor J. Wardill, Cahir J. O’Kane
Aug 24, 2020
Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To...
Measurement and modelling of dark current decay transients in perovskite solar cells
Simon E. J. O'Kane, Giles Richardson, Adam Pockett, Ralf G. Niemann, James M. Cave, Nobuya Sakai, Giles E. Eperon, Henry J. Snaith, Jamie M. Foster, Petra J. Cameron, Alison B. Walker
Jan 14, 2017
The current decay in response to a sudden change of applied bias up to 1 V has been measured on a methylammonium lead triiodide perovskite solar cell with titania and spiro-OMeTAD transport layers, for temperatures between 258...
Measurement and modelling of dark current decay transients in perovskite solar cells
Simon E. J. O'Kane, Giles Richardson, Adam Pockett, Ralf G. Niemann, James M. Cave, Nobuya Sakai, Giles E. Eperon, Henry J. Snaith, Jamie M. Foster, Petra J. Cameron, Alison B. Walker
Jan 14, 2017
The current decay in response to a sudden change of applied bias up to 1 V has been measured on a methylammonium lead triiodide perovskite solar cell with titania and spiro-OMeTAD transport layers, for temperatures between 258...
Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury.
Alastair Proudfoot, Andrew Bayliffe, Cecilia M O'Kane, Tracey Wright, Adrian Serone, Philippe Jean Bareille, Vanessa Brown, Umar I Hamid, Younan Chen, Robert Wilson, Joanna Cordy, Peter Morley, Ruud de Wildt, Stuart Elborn, Matthew Hind, Edwin R Chilvers, Mark Griffiths, Charlotte Summers, Daniel Francis McAuley
Feb 26, 2018
BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the...
ARDS Neutrophil Biology Acute Lung Injury Animals Antibodies Monoclonal Antibodies Monoclonal Humanized Biomarkers Pharmacological Bronchoalveolar Lavage Fluid Dose-Response Relationship Drug Endothelial Cells Flow Cytometry Humans Inflammation Macaca fascicularis Molecular Targeted Therapy Nebulizers and Vaporizers Pharmacology clinical Receptors Tumor Necrosis Factor Type I Signal Transduction Translational Research Biomedical
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Liang Wei Wang, Hongying Shen, Luis Nobre, Ina Ersing, Joao A Paulo, Stephen Trudeau, Zhonghao Wang, Nicholas A Smith, Yijie Ma, Bryn Reinstadler, Jason Nomburg, Thomas Sommermann, Ellen Cahir-McFarland, Steven P Gygi, Vamsi K Mootha, Michael P Weekes, Benjamin E Gewurz
Jun 05, 2019
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were...
B-cell activation de novo serine synthesis folate isotope tracing metabolic remodeling mitochondrial one-carbon metabolism quantitative proteomics tandem mass tag tumor virus virus oncoprotein Aminohydrolases B-Lymphocytes Cell Transformation Viral Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Folic Acid Glycolysis HEK293 Cells Herpesvirus 4 Human Humans Lymphocyte Activation Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Multifunctional Enzymes NADP Oxidation-Reduction Proteome Proto-Oncogene Proteins c-myc Serine
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