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Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine
Current human immunodeficiency virus (HIV) vaccine approaches emphasize prime boost strategies comprising multiple doses of DNA vaccine and recombinant viral vectors. We are developing a protein-based approach that directly...
Published by: Rockefeller University
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
Friederike M Dannheim, Stephen J Walsh, Carolina T Orozco, Anders Højgaard Hansen, Jonathan D Bargh, Sophie E Jackson, Nicholas J Bond, Jeremy S Parker, Jason S Carroll, David R Spring
Sep 16, 2022
Antibody-drug conjugates (ADCs) are valuable therapeutic entities which leverage the specificity of antibodies to selectively deliver cytotoxins to antigen-expressing targets such as cancer cells. However, current methods for...
B-hadron production in NNLO QCD
We calculate, for the first time, the NNLO QCD corrections to identified
heavy hadron production at hadron colliders. The calculation is based on a
flexible numeric framework which allows the calculation of any distribution of
a...
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Mechanistic insights into the rational design of masked antibodies.
Carolina T Orozco, Manuela Bersellini, Lorraine M Irving, Wesley W Howard, David Hargreaves, Paul WA Devine, Elise Siouve, Gareth J Browne, Nicholas J Bond, Jonathan J Phillips, Peter Ravn, Sophie E Jackson
Aug 07, 2022
Although monoclonal antibodies have greatly improved cancer therapy, they can trigger side effects due to on-target, off-tumor toxicity. Over the past decade, strategies have emerged to successfully mask the antigen-binding site...
Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation.
Carolina T Orozco, Matthew J Edgeworth, Paul WA Devine, Alistair R Hines, Owen Cornwell, Christopher Thompson, Xiangyang Wang, Jonathan J Phillips, Peter Ravn, Sophie E Jackson, Nicholas J Bond
Nov 10, 2021
Enrollment Figures for 1946-1947 - North Carolina
Winthrop News Service
Jan 01, 0001
Students from North Carolina numbered 39 enrolled at Winthrop in 1946-1947 Students from York County were the most numerous enrolled at Winthrop during the 1946-1947 academic year
Published by: Winthrop University
Create Carolina Festival Takes Look at Politics
Winthrop University
Jan 01, 0001
The second annual Create Carolina Arts Festival: A Southern Fried Arts and Film Festival will focus on politics during this presidential election year, as well as showcasing independent films.
Published by: Winthrop University
Interaction between known risk factors for head and neck cancer and socioeconomic status
Gaelen Stanford-Moore, Patrick T Bradshaw, Mark C Weissler, Jose P Zevallos, Paul Brennan, Devasena Anantharaman, Behnoush Abedi-Ardekani, Andrew F Olshan
Nov 23, 2018
Prior studies of squamous cell carcinoma of the head and neck (SCCHN) have explored the effect of socioeconomic status (SES) as an independent risk factor; however, none have investigated the interaction of known risk factors...
Alcohol Case–control studies EPIDEMIOLOGY Head and neck cancer Risk Factors Socioeconomic status Tobacco Adult Aged Aged 80 and over Alcohol Drinking Carcinoma Squamous Cell Case-Control Studies Female Head and Neck Neoplasms Humans Income Logistic Models Male Middle Aged North Carolina Odds Ratio Oral Health Risk Factors Smoking Social Class Squamous Cell Carcinoma of Head and Neck Young Adult
Interview with Booker T. Brown - OH 689
This interview was conducted by Dr. George Garrison with Booker T. Brown with a focus on the History of Emmett Scott High School. Emmett Scott was the segregated high school for African-Americans, which was named after Emmett...
Published by: Winthrop University
Shakespeare Carolina at Winthrop to Present Two Productions This Summer
Winthrop University
Jan 01, 0001
Shakespeare Carolina will offer performances of "Two Gentlemen of Verona" and "The Tempest" in July and August. The classical theatre company has formed a partnership with Winthrop called Shakespeare Carolina at Winthrop.
Published by: Winthrop University
''Much Ado About Nothing'' Signals New Winthrop, Shakespeare Carolina Partnership
Winthrop University
Jan 01, 0001
"Much Ado About Nothing" will mark a new partnership between Shakespeare Carolina and Winthrop University. Shakespeare Carolina and Winthrop's College of Visual and Performing Arts/Department of Theatre and Dance leadership will...
Published by: Winthrop University
South Carolina Scholastic Press Association Workshop Cancelled
Winthrop News Service
Jan 01, 0001
South Carolina Scholastic Press Association was founded in 1936 by Fred C. Kendrick, newspaper advisor at Greenville High School. The association offers support and resources for student journalists by sponsoring annual...
Published by: Winthrop University
The South Carolina Ag + Art Tour
This presentation discusses the South Carolina Ag + Art Tour, how it came to be, its purposes, effects and successes in the tour's seven-year history.
Published by: Winthrop University
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Extracellular Lactate
James T Grist, Lorna B Jarvis, Zoya Georgieva, Sara Thompson, Harpreet Kaur Sandhu, Keith Burling, Ashley Clarke, Sarah Jackson, Mark Wills, Ferdia A Gallagher, Joanne L Jones
Feb 23, 2018
Following activation, T cells rapidly divide and acquire effector functions. This energetically demanding process depends upon the ability of T cells to undergo metabolic remodeling from oxidative phosphorylation to aerobic...
T Lymphocytes in Histiocytic Sarcomas of Flat-Coated Retriever Dogs.
Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...
First Create Carolina Festival Lasts May 14-June 2
Winthrop University
Jan 01, 0001
Winthrop University will present Charles Randolph-Wright's play "Medal of Honor Rag" as part of the Create Carolina Arts Festival. Showtimes will be May 15-26 and June 2 in Johnson Theatre.
Published by: Winthrop University
''Friends'' Producer to Speak at Create Carolina Festival
Winthrop University
Jan 01, 0001
Kevin Bright, producer for "Friends," will be a visiting artist during the Create Carolina Arts Festival. Bright will co-teach a master class on May 26 in Johnson Studio Theatre.
Published by: Winthrop University
Shakespeare Carolina at Winthrop Revamps ''The Tempest'' Aug. 3-7
Winthrop University
Jan 01, 0001
"The Tempest" is Shakespeare Carolina at Winthrop's second production. Tickets are $15 for adults and $10 for students and seniors.
Published by: Winthrop University
Family Ties: The Gibbs Family, Race, and Society in South Carolina: 1865-1945
Andre Thompson
Jan 01, 0001
The ancestors of the Gibbs family came to South Carolina as slaves from Barbados in the early 19th C., and four brothers, Anthony, Fortune, Moses and Wetus, born in South Carolina between 1832 and 1845, all grew up as slaves and...
Gibbs Family Reconstruction rice Great Migration Landowning Farmers AME Zion South Carolina Low Country History United States History
Published by: Winthrop University
Play Commissioned for Create Carolina Debuts This Week
Winthrop University
Jan 01, 0001
"Home! Now!!" will debut during the Create Carolina Arts Festival. The performance of "Medal of Honor Rag" on Winthrop's campus will be the festival's final event.
Published by: Winthrop University
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
The Political Intervention and Public Policy Influencing High Tuition Rates at South Carolina Colleges and Universities
Zuri Anderson
Jan 01, 0001
Winthrop University students often ask why the institution's tuition rates are so high. This is an important question for students, who wonder why they pay higher tuition and fees to Winthrop compared to other universities with...
Published by: Winthrop University
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