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Results: 2148
Management of chronic Achilles ruptures
PURPOSE: This scoping review aims to systematically map and summarise the available evidence on the management of chronic Achilles ruptures, whilst identifying prognostic factors and areas of future research. METHODS: A scoping...
Management of chronic osteomyelitis of the femur and tibia
Osteomyelitis refers to an inflammatory process causing bone destruction and necrosis. Managing such a persistent disease is complex, with a number of authors reporting different techniques. This scoping review aims to map and...
Interview with Edward "Ed" Harris, Brenda Dow, and Sylvester King - OH 296
In May of 2013 Mr. Edward Harris sat down and discussed his brother, Herman K. Harris, who was a part of the freedom riders. Mr. Harris also discusses his military service and his tour of duty in Vietnam. This interview was...
Sharecropper African American education Southern Family Heath Springs South Carolina Segregation Freedom Riders KKK Vietnam PTSD Oral History
Published by: Winthrop University
Interview with Edward Bynum - OH 322
This collection includes an interview of Edward Bynum (1933-2012) concerning his work with the Dr. James R. Clark Memorial Sickle Cell Anemia Foundation. Bynum discusses his education, his service in the Korean War on a hospital...
Sickle cell anemia and trait Thalassemia James R. Clark Memorial Sickle Cell Foundation CDC (Centers for Disease Control and Prevention) DHEC (Department of Health and Environmental Control) Hematology Dr. James R. Clark Oral History
Published by: Winthrop University
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Jan 22, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun
Daniel Baxter, Samuel Perry, Timothy Hill, Woan Kok, Nathan Zaccai, Leo Brady, David Fairlie, Jody Mason
Aug 18, 2017
The oncogenic transcription factor Activator Protein-1 (AP-1) is a DNA binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled coil...
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.
Sympathetic neurons depend on NGF binding to TrkA for their survival during vertebrate development. NGF deprivation initiates a transcription-dependent apoptotic response, which is suggested to require activation of the...
Animals Apoptosis Base Sequence Brain-Derived Neurotrophic Factor Cells Cultured Cycloheximide Gene Expression Regulation Developmental Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents Integrases Luminescent Proteins Mice Mice Knockout Mutation Nerve Growth Factor Neurons Protein Synthesis Inhibitors Proto-Oncogene Proteins c-jun Receptor Nerve Growth Factor Superior Cervical Ganglion Transfection Viral Proteins
Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun.
Laura J Wagstaff, Jose A Gomez-Sanchez, Shaline V Fazal, Georg W Otto, Alastair M Kilpatrick, Kirolos Michael, Liam YN Wong, Ki H Ma, Mark Turmaine, John Svaren, Tessa Gordon, Peter Arthur-Farraj, Sergio Velasco-Aviles, Hugo Cabedo, Cristina Benito, Rhona Mirsky, Kristjan R Jessen
Mar 15, 2021
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...
Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons.
Jessica CF Kwok, Ying-Lai Yuen, Wai-Kit Lau, Fu-Xing Zhang, James W Fawcett, Ying-Shing Chan, Daisy KY Shum
Mar 06, 2012
Organising Support for Carers of Stroke Survivors (OSCARSS)
Emma Patchwood, Katy Rothwell, Sarah Rhodes, Evridiki Batistatou, Kate Woodward-Nutt, Yiu-Shing Lau, Gunn Grande, Gail Ewing, Audrey Bowen
Nov 03, 2020
BACKGROUND: Stroke often results in chronic disability, with partners and family members taking on the role of informal caregiver. There is considerable uncertainty regarding how best to identify and address carers' needs. The...
Carers Cluster randomised controlled trial complex intervention health service service user involvement health economics qualitative interviews Informal caregivers stroke Adult Caregivers Cost-Benefit Analysis Humans Multicenter Studies as Topic Needs Assessment Pragmatic Clinical Trials as Topic Sample Size stroke Survivors
INFIDELS IN ENGLISH LEGAL THOUGHT
English common law reports are dense with ideas. Yet they remain mostly untapped by intellectual historians. This article reveals how intellectual history can engage with law and jurisprudence by following the notion...
EDWARD CAVANAGH
Sep 08, 2018
Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach.
Timothy I Johnson, Christopher J Minteer, Daniel Kottmann, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Larissa S Carnevalli, Yann Wallez, Alan Lau, Frances M Richards, Duncan I Jodrell
Jun 28, 2021
Background
Chemotherapy and targeted agent anti-cancer efficacy is largely dependent on the proliferative state of tumours, as exemplified by agents that target DNA synthesis/replication or mitosis. As a result, cell...
Published by: EBioMedicine
Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach.
Timothy I Johnson, Christopher J Minteer, Daniel Kottmann, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Larissa S Carnevalli, Yann Wallez, Alan Lau, Frances M Richards, Duncan I Jodrell
Jul 26, 2021
BACKGROUND: Chemotherapy and targeted agent anti-cancer efficacy is largely dependent on the proliferative state of tumours, as exemplified by agents that target DNA synthesis/replication or mitosis. As a result, cell cycle...
Cancer Cell Cycle Combination treatment high throughput screening synchronisation Cell Culture Techniques Cell Cycle Cell Line Tumor Cell Proliferation Cell Survival Deoxycytidine Drug Screening Assays Antitumor Drug Synergism HeLa Cells High-Throughput Screening Assays Humans MCF-7 Cells Neoplasms Nocodazole Piperazines Pyridines Small Molecule Libraries Time Factors Tubulin Modulators Gemcitabine
Rough Music and Charivari
Alexandra Walsham
Oct 31, 2018
In 1971 Natalie Zemon Davis published a seminal article in the pages of Past and Present, entitled ‘The Reasons of Misrule: Youth Groups and Charivaris in Sixteenth-Century France’. A study of the carnivalesque rituals of...
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, Peng Li, Yoshiyuki Wakabayashi, Kylie M Quinn, Christopher A Klebanoff, Yun Ji, Madhusudhanan Sukumar, Robert L Eil, Zhiya Yu, Rosanne Spolski, Douglas C Palmer, Jenny H Pan, Shashank J Patel, Derek C Macallan, Giulia Fabozzi, Han-Yu Shih, Yuka Kanno, Akihiko Muto, Jun Zhu, Luca Gattinoni, John J O'Shea, Klaus Okkenhaug, Kazuhiko Igarashi, Warren J Leonard, Nicholas P Restifo
Jun 27, 2018
T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is...
Adaptive Immunity Animals Basic-Leucine Zipper Transcription Factors CD8-Positive T-Lymphocytes Cell Differentiation Cells Cultured Enhancer Elements Genetic Gene Expression Regulation Immunologic Memory Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Oncogene Protein p65(gag-jun) Signal Transduction Transcription Factor AP-1 Vaccinia vaccinia virus
A New Resource Recovery Process for Refining Sludge Generated by a Paper Manufacturing Company
A new sludge processing method was developed by the Beta Company, a paper manufacturing company. The new method will shorten the time for transforming sludge into organic fertilizers, which will improve the process of handling...
Published by: IGI Global Scientific Publishing
Assessing the Level of Community Resilience to Drought in Kitui County, Kenya
In Kenya, arid and semi-arid lands are more affected by drought due to their fragile ecosystems and unfavorable climate. The main objective of this study was to determine the level of community resilience to drought in Kitui...
Published by: IGI Global Scientific Publishing
Friends, Former Students of Winthrop History Professor Establish Scholarship
Winthrop University
Jan 01, 0001
The J. Edward Lee Scholarship will support graduate students majoring in history. Lee has been a Department of History faculty member since 1994.
Published by: Winthrop University
A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Sergio Velasco-Aviles, Nikiben Patel, Angeles Casillas-Bajo, Laura Frutos-Rincón, Enrique Velasco-Serna, Juana Gallar, Peter Arthur-Farraj, Jose A Gomez-Sanchez, Hugo Cabedo
Feb 17, 2022
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...
An M-Learning Model in the Context of the Blended Synchronous Learning Environment
Mobile learning provides more flexibility and holds considerable promise for improving the learning process and promoting lifelong learning. In order to reduce the sense of isolation felt by the learners, this research...
Published by: IGI Global Scientific Publishing
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