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Colocalization Features for Classification of Tumors Using Desorption Electrospray Ionization Mass Spectrometry Imaging.
Supervised modeling of mass spectrometry imaging (MSI) data is a crucial component for the detection of the distinct molecular characteristics of cancerous tissues. Currently, two types of supervised analyses are mainly used on...
The incidence of cervical cancer in women with postcoital bleeding and abnormal appearance of the cervix referred through the 2-week wait pathway in the United Kingdom
AIM: To determine the incidence of cervical cancer in women referred through the 2-week-wait pathway for postcoital bleeding and abnormal appearance of the cervix. METHODS: A retrospective cohort study was conducted of women...
cervical intraepithelial neoplasia colposcopy Incidence Referral and Consultation Uterine Cervical Neoplasms Pregnancy Female Humans Uterine Cervical Neoplasms Cervix Uteri Colposcopy Early Detection of Cancer Incidence Retrospective Studies Referral and Consultation Hemorrhage United Kingdom Uterine Cervical Dysplasia
High order splitting methods for SDEs satisfying a commutativity condition
In this paper, we introduce a new simple approach to developing and establishing the convergence of splitting methods for a large class of stochastic differential equations (SDEs), including additive, diagonal, and scalar...
Machine learning for target discovery in drug development.
Chemical probes Chemical proteomics Drug Discovery Machine Learning target identification Antineoplastic Agents Computer Simulation Drug Evaluation Preclinical Humans lipoxygenase Machine Learning Molecular Targeted Therapy Naphthoquinones Pentacyclic Triterpenes Proteomics Receptors Cannabinoid Sesquiterpenes Sesquiterpenes Guaiane Transient Receptor Potential Channels
Antikörpergerichtete Therapien
In its various forms, cancer remains a leading cause of mortality and morbidity worldwide. Thus, it is widely accepted that finding innovative, life-changing drugs and therapeutic regimens is key for successful future cancer...
Protein-Protein Conjugates
The residues cysteine and lysine are the undisputed champions of bioconjugation chemistry. Targeting other amino acids has been touted as a potential way to improve the synthesis of protein–peptide and protein–protein conjugates...
The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery.
Activity-based protein profiling (ABPP) is an approach used at the interface of chemical biology and proteomics that uses small molecular probes to provide dynamic fingerprints of enzymatic activity in complex proteomes. Malaria...
High order splitting methods for SDEs satisfying a commutativity condition
In this paper, we introduce a new simple approach to developing and establishing the convergence of splitting methods for a large class of stochastic differential equations (SDEs), including additive, diagonal, and scalar...
Bioorthogonal Decaging Reactions for Targeted Drug Activation.
Bioorthogonal decaging reactions are highly selective transformations which involve the cleavage of a protecting group from a molecule of interest. Decaging reactions can be classified into subgroups depending on the nature of...
Development of Antibody-Directed Therapies
Less is more: The efficacy of antibody-drug conjugates (ADCs) for cancer therapy is traditionally associated with cleavable linkers for payload release. Evidence now suggests that simpler constructs without cleavable moieties...
Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
Benzhydryl Compounds Binding Sites Breast Neoplasms Catalase Cytochrome P-450 CYP1A2 Databases Chemical Databases Protein Dioxins Endocrine Disruptors Environmental Pollutants Female Humans Molecular Dynamics Simulation Phenols Protein Binding Protein Structure Tertiary Recombinant Proteins Sex Hormone-Binding Globulin
Editorial overview
Chemical biology, a terminology coined early on in the mid-1940s in acorrespondence from George Beadle to Linus Pauling, has been laterdefined as ‘work in chemistry which is of biological interestdand to thatwork in biology in...
A Sweet Galactose Transfer
The introduction of chemical reporter groups into glycan structures through metabolic oligosaccharide engineering (MOE) followed by bio-orthogonal ligation is an important tool to study glycosylation. We show the incorporation...
The role of reversible and irreversible covalent chemistry in targeted protein degradation.
Proteolysis-targeting chimeras (PROTACs) that degrade disease-causing proteins by hijacking the endogenous ubiquitin-proteasome system have emerged as an exciting and transformative technology in both chemical biology and drug...
Tetrazine Carbon Nanotubes for Pretargeted In Vivo "Click-to-Release" Bioorthogonal Tumour Imaging.
The bioorthogonal inverse-electron-demand Diels-Alder (IEDDA) cleavage reaction between tetrazine and trans-cyclooctene (TCO) is a powerful way to control the release of bioactive agents and imaging probes. In this study, a...
π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation.
Ross J Taylor, Mauricio Aguilar Rangel, Michael B Geeson, Pietro Sormanni, Michele Vendruscolo, Gonçalo JL Bernardes
Aug 14, 2022
Post-translational protein-protein conjugation produces bioconjugates that are unavailable via genetic fusion approaches. A method for preparing protein-protein conjugates using π-clamp-mediated cysteine arylation with...
Increased canine pancreatic lipase immunoreactivity (cPLI) and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) lipase in dogs with evidence of portal hypertension and normal pancreatic histology
The clinical presentations of both liver disease and pancreatitis are nonspecific and overlapping, which may cause difficulty in diagnosis. In our retrospective pilot study, we assessed whether dogs with evidence of portal...
DGGR lipase (1 2-o-dilauryl-rac-glycero-3-glutaricacid-(6′-methylresorufin) ester) MAPSS (multiple acquired portosystemic shunts) Spec cPL (canine pancreas-specific lipase) cPLI (canine pancreatic lipase immunoreactivity) Dogs Liver portal hypertension Animals Dog Diseases Dogs Hypertension Portal LIPASE Pancreas Pancreatitis Pilot Projects Retrospective Studies
Site-selective installation of an electrophilic handle on proteins for bioconjugation.
Site-selective protein modification strategies can be used to insert non-natural functional groups into protein structures. Herein, we report on the use of the bis-electrophile 3-bromo-2-bromomethyl-1-propene as a reagent to...
Chemical and Enzymatic Methods for Post-Translational Protein-Protein Conjugation.
Fusion proteins play an essential role in the biosciences but suffer from several key limitations, including the requirement for N-to-C terminal ligation, incompatibility of constituent domains, incorrect folding, and loss of...
Posttranslational Chemical Mutagenesis
The field of chemical site-selective modification of proteins has progressed extensively in recent decades to enable protein functionalization for imaging, drug delivery, and functional studies. In this Perspective, we provide...
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