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Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
A Saini, AR Norman, D Cunningham, I Chau, M Hill, D Tait, T Hickish, T Iveson, F Lofts, D Jodrell, PJ Ross, J Oates
Sep 02, 2020
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic...
Numerical Modelling of the Dynamic Voltage in HTS Materials under the Action of DC Transport Currents and Different Oscillating Magnetic Fields.
The dynamic voltage is a unique phenomenon of superconducting materials. It arises when the superconductor is carrying a DC transport current and spontaneously in subject to an AC magnetic field. This study excavates the aspects...
Numerical Modelling of the Dynamic Voltage in HTS Materials under the Action of DC Transport Currents and Different Oscillating Magnetic Fields.
The dynamic voltage is a unique phenomenon of superconducting materials. It arises when the superconductor is carrying a DC transport current and spontaneously in subject to an AC magnetic field. This study excavates the aspects...
Adaptive Optimization Algorithm for Resetting Techniques in Obstacle-ridden Environments
Redirected Walking (RDW) algorithms aim to impose several types of gains on users immersed in Virtual Reality and distort their walking paths in the real world, thus enabling them to explore a larger space. Since collision...
Adaptive optimization Heuristic algorithms Layout Legged locomotion Navigation Obstacle-ridden area OPTIMIZATION Redirected walking Redirection Resetting Space exploration Space vehicles /dk/atira/pure/subjectarea/asjc/1700/1712 name=Software /dk/atira/pure/subjectarea/asjc/1700/1711 name=Signal Processing /dk/atira/pure/subjectarea/asjc/1700/1707 name=Computer Vision and Pattern Recognition /dk/atira/pure/subjectarea/asjc/1700/1704 name=Computer Graphics and Computer-Aided Design
Adaptive Optimization Algorithm for Resetting Techniques in Obstacle-ridden Environments
Redirected Walking (RDW) algorithms aim to impose several types of gains on users immersed in Virtual Reality and distort their walking paths in the real world, thus enabling them to explore a larger space. Since collision...
Adaptive optimization Heuristic algorithms Layout Legged locomotion Navigation Obstacle-ridden area OPTIMIZATION Redirected walking Redirection Resetting Space exploration Space vehicles /dk/atira/pure/subjectarea/asjc/1700/1712 name=Software /dk/atira/pure/subjectarea/asjc/1700/1711 name=Signal Processing /dk/atira/pure/subjectarea/asjc/1700/1707 name=Computer Vision and Pattern Recognition /dk/atira/pure/subjectarea/asjc/1700/1704 name=Computer Graphics and Computer-Aided Design
Mechanism of Iron Oxide-Induced Macrophage Activation
Zhengying Gu, Tianqing Liu, Jie Tang, Yannan Yang, Hao Song, Zewen K Tuong, Jianye Fu, Chengzhong Yu
May 13, 2019
Mating-driven variability in olfactory local interneuron wiring.
Ya-Hui Chou, Chi-Jen Yang, Hao-Wei Huang, Nan-Fu Liou, Michael Raphael Panganiban, David Luginbuhl, Yijie Yin, Istvan Taisz, Liang Liang, Gregory SXE Jefferis, Liqun Luo
Mar 21, 2022
Variations in neuronal connectivity occur widely in nervous systems from invertebrates to mammals. Yet, it is unclear how neuronal variability originates, to what extent and at what time scales it exists, and what functional...
Secondary Metabolites of Osmanthus fragrans
Chen-Chen Fu, Fa-Ying Xu, Yu-Chen Qian, Hoi-Lun Koo, Yi-Fan Duan, Geng-Min Weng, Tai-Ping Fan, Mo-Xian Chen, Fu-Yuan Zhu
Aug 01, 2022
Osmanthus fragrans (scientific name: Osmanthus fragrans (Thunb.) Lour.) is a species of the Osmanthus genus in the family Oleaceae, and it has a long history of cultivation in China. O. fragrans is edible and is well known for...
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
5-Fluorouracil 5-methyluridine DNA break repair NUD1 RNA methylation TRMT2A homologous recombination /dk/atira/pure/subjectarea/asjc/2700/2730 name=Oncology /dk/atira/pure/subjectarea/asjc/1300/1306 name=Cancer Research /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Sub-picosecond photo-induced displacive phase transition in two-dimensional MoTe 2
Bo Peng, Hao Zhang, Weiwen Chen, Bowen Hou, Zhi-Jun Qiu, Hezhu Shao, Heyuan Zhu, Bartomeu Monserrat, Desheng Fu, Hongming Weng, Costas M. Soukoulis
Jun 12, 2020
Abstract: Photo-induced phase transitions (PIPTs) provide an ultrafast, energy-efficient way for precisely manipulating the topological properties of transition-metal ditellurides and can be used to stabilize a topological phase...
Intensive Imaging-based Follow-up of Surgically Treated Localised Renal Cell Carcinoma Does Not Improve Post-recurrence Survival
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel Paul Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
Dec 03, 2018
The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association...
Topical treatment of actinic keratoses in organ transplant recipients
Zeeshaan-Ul Hasan, Ikhlaaq Ahmed, Rubeta N Matin, Victoria Homer, John T Lear, Ferina Ismail, Tristan Whitmarsh, Adele C Green, Jason Thomson, Alan Milligan, Sarah Hogan, Vanessa Van-de-Velde, Liza Mitchell-Worsford, Jonathan Kentley, Claire Gaunt, Yolande Jefferson-Hulme, Sarah J Bowden, Piers Gaunt, Keith Wheatley, Charlotte M Proby, Catherine A Harwood
Jun 14, 2022
BACKGROUND: The risk of cutaneous squamous cell carcinoma (cSCC) is significantly increased in organ transplant recipients (OTRs). Clearance of actinic keratoses (AKs) is generally regarded as a surrogate biomarker for cSCC...
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
5-Fluorouracil 5-methyluridine DNA break repair NUD1 RNA methylation TRMT2A homologous recombination /dk/atira/pure/subjectarea/asjc/2700/2730 name=Oncology /dk/atira/pure/subjectarea/asjc/1300/1306 name=Cancer Research /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Enhanced Hygrothermal Stability of In-Situ-Grown MAPbBr<sub>3</sub> Nanocrystals in Polymer with Suppressed Desorption of Ligands
Hui Fu, Kai Wang, Hao Wu, Chris R. Bowen, Zhi Fang, Zebin Yan, Shuheng Jiang, Deliu Ou, Yang Yang, Jinju Zheng, Weiyou Yang
Aug 21, 2023
Currently, the intrinsic instability of organic-inorganic hybrid perovskite nanocrystals (PNCs) at high temperature and high humidity still stands as a big barrier to hinder their potential applications in optoelectronic...
Enhanced Hygrothermal Stability of In-Situ-Grown MAPbBr<sub>3</sub> Nanocrystals in Polymer with Suppressed Desorption of Ligands
Hui Fu, Kai Wang, Hao Wu, Chris R. Bowen, Zhi Fang, Zebin Yan, Shuheng Jiang, Deliu Ou, Yang Yang, Jinju Zheng, Weiyou Yang
Aug 21, 2023
Currently, the intrinsic instability of organic-inorganic hybrid perovskite nanocrystals (PNCs) at high temperature and high humidity still stands as a big barrier to hinder their potential applications in optoelectronic...
A Corpus-Based Study on the Translation Style of Five English Versions of Fu Sheng Liu Ji, Vol I
Bing Zhang
Oct 31, 2022
Using a corpus approach, this article investigates the translation styles of the first chapter of Fu Sheng Liu Ji at three levels: the statistical parameters, the translation of culture-specific lexis, and readability...
Published by: IGI Global Scientific Publishing
A Middle Pleistocene Denisovan molar from the Annamite Chain of northern Laos.
Fabrice Demeter, Clément Zanolli, Kira E Westaway, Renaud Joannes-Boyau, Philippe Duringer, Mike W Morley, Frido Welker, Patrick L Rüther, Matthew M Skinner, Hugh McColl, Charleen Gaunitz, Lasse Vinner, Tyler E Dunn, Jesper V Olsen, Martin Sikora, Jean-Luc Ponche, Eric Suzzoni, Sébastien Frangeul, Quentin Boesch, Pierre-Olivier Antoine, Lei Pan, Song Xing, Jian-Xin Zhao, Richard M Bailey, Souliphane Boualaphane, Phonephanh Sichanthongtip, Daovee Sihanam, Elise Patole-Edoumba, Françoise Aubaile, Françoise Crozier, Nicolas Bourgon, Alexandra Zachwieja, Thonglith Luangkhoth, Viengkeo Souksavatdy, Thongsa Sayavongkhamdy, Enrico Cappellini, Anne-Marie Bacon, Jean-Jacques Hublin, Eske Willerslev, Laura Shackelford
Jun 29, 2022
The Pleistocene presence of the genus Homo in continental Southeast Asia is primarily evidenced by a sparse stone tool record and rare human remains. Here we report a Middle Pleistocene hominin specimen from Laos, with the...
A Middle Pleistocene Denisovan molar from the Annamite Chain of northern Laos.
Fabrice Demeter, Clément Zanolli, Kira E Westaway, Renaud Joannes-Boyau, Philippe Duringer, Mike W Morley, Frido Welker, Patrick L Rüther, Matthew M Skinner, Hugh McColl, Charleen Gaunitz, Lasse Vinner, Tyler E Dunn, Jesper V Olsen, Martin Sikora, Jean-Luc Ponche, Eric Suzzoni, Sébastien Frangeul, Quentin Boesch, Pierre-Olivier Antoine, Lei Pan, Song Xing, Jian-Xin Zhao, Richard M Bailey, Souliphane Boualaphane, Phonephanh Sichanthongtip, Daovee Sihanam, Elise Patole-Edoumba, Françoise Aubaile, Françoise Crozier, Nicolas Bourgon, Alexandra Zachwieja, Thonglith Luangkhoth, Viengkeo Souksavatdy, Thongsa Sayavongkhamdy, Enrico Cappellini, Anne-Marie Bacon, Jean-Jacques Hublin, Eske Willerslev, Laura Shackelford
May 18, 2022
The Pleistocene presence of the genus Homo in continental Southeast Asia is primarily evidenced by a sparse stone tool record and rare human remains. Here we report a Middle Pleistocene hominin specimen from Laos, with the...
Sub-picosecond photo-induced displacive phase transition in two-dimensional MoTe 2
Bo Peng, Hao Zhang, Weiwen Chen, Bowen Hou, Zhi-Jun Qiu, Hezhu Shao, Heyuan Zhu, Bartomeu Monserrat, Desheng Fu, Hongming Weng, Costas M. Soukoulis
Feb 17, 2021
Abstract: Photo-induced phase transitions (PIPTs) provide an ultrafast, energy-efficient way for precisely manipulating the topological properties of transition-metal ditellurides and can be used to stabilize a topological phase...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
Bilateral Habenula deep brain stimulation for treatment-resistant depression
Chencheng Zhang, Yingying Zhang, Huichun Luo, Xinmeng Xu, Ti-Fei Yuan, Dianyou Li, Yi-Yun Cai, Hengfen Gong, Dai-Hui Peng, Yi-Ru Fang, Valerie Voon, Bomin Sun
Mar 07, 2022
Deep brain stimulation (DBS) of structures in the brain's reward system is a promising therapeutic option for patients with treatment-resistant depression (TRD). Recently, DBS of the habenula (HB) in the brain's anti-reward...
“Small, yet Beautiful”
We reconsider whether a grand multi-winner contest elicits more equilibrium effort than a collection of sub-contests. Fu and Lu (2009) employ a sequential winner-selection mechanism and find support for running a grand contest....
Intrusion Detection Using Normalized Mutual Information Feature Selection and Parallel Quantum Genetic Algorithm
This paper presents a detection algorithm using normalized mutual information feature selection and cooperative evolution of multiple operators based on adaptive parallel quantum genetic algorithm (NMIFS MOP- AQGA). The proposed...
Published by: IGI Global Scientific Publishing
Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer.
Aurélie Courtin, Frances M Richards, Tashinga E Bapiro, Jo L Bramhall, Albrecht Neesse, Natalie Cook, Ben-Fillippo Krippendorff, David A Tuveson, Duncan I Jodrell
Feb 12, 2020
Capecitabine (CAP) is a 5-FU pro-drug approved for the treatment of several cancers and it is used in combination with gemcitabine (GEM) in the treatment of patients with pancreatic adenocarcinoma (PDAC). However, limited...
Animals Antineoplastic Combined Chemotherapy Protocols Capecitabine Carcinoma Pancreatic Ductal Cell Line Tumor Cytidine Deaminase Deoxycytidine Disease Models Animal Drug Screening Assays Antitumor Fluorouracil Mice Mice Transgenic Neoplasm Transplantation Pancreatic Neoplasms prodrugs Tissue Distribution Gemcitabine
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