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Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution.
Natalie L Mutter, Misha Soskine, Gang Huang, Inês S Albuquerque, Gonçalo JL Bernardes, Giovanni Maglia
Dec 04, 2018
Immunotoxins are proteins containing a cell-targeting element linked to a toxin that are under investigation for next-generation cancer treatment. However, these agents are difficult to synthesize, chemically heterogeneous...
Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle.
Activation of skeletal muscle fibers requires rapid sarcolemmal action potential (AP) conduction to ensure uniform excitation along the fiber length, as well as successful tubular excitation to initiate excitation-contraction...
Suppression of erythropoiesis by dietary nitrate.
T Ashmore, BO Fernandez, CE Evans, Y Huang, C Branco-Price, JL Griffin, RS Johnson, M Feelisch, AJ Murray
Dec 05, 2016
The Grizzly, December 6, 2012
Jessica Orbon, Sara Sherr, Larissa Coyne, Keith Miles, John Parry, Olivia Z. Schultz, Rayleen Rivera-Harbach, Jordan Demcher, Michael D'Amico, Alexa LaMontagne, Austin Fox, Andrew Feick, Lea Marano, Allen Weaver, Joey Brodsky
Jan 01, 0001
Dean Addresses New Faculty Rumors Main Street Accident Raises Crosswalk Safety Concerns Infonet's Future Still Uncertain New Director Plans Art Exhibits UCARE Grants Kids' Wishes The Ruby Tradition Continues Best Buddies...
Ursinus College Collegeville Pennsylvania newspaper adjunct professors Main Street safety harassment Charles Stainback Berman Art Museum UCARE Ruby Best Buddies Messiah Sarah Huang vandalism Kathy Peck Carole Nienius Basketball Swimming wrestling track team cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Central Tracking and Billing System for Insurance Bills
Kehinde Alabi
Jan 01, 0001
In this article, we introduce a new centralized billing platform designed for insurance bills including auto insurance, health insurance, home insurance, life insurance, etc. This system consolidates all bills for individual...
Centralized billing system Insurance payment management Automated bill tracking Missed payments prevention Financial management technology User satisfaction in billing systems Cost savings in insurance billing Revenue management efficiency Regulatory compliance in billing Payment consolidation. Business Health and Medical Administration health information technology Human Resources Management insurance Management Information Systems Medicine and Health Sciences Operations Research, Systems Engineering and Industrial Engineering systems engineering Telemedicine
Published by: Harrisburg University of Science and Technology
Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling.
Leon Tribolet, Cinzia Cantacessi, Darren A Pickering, Severine Navarro, Denise L Doolan, Angela Trieu, Huang Fei, Yang Chao, Andreas Hofmann, Robin B Gasser, Paul R Giacomin, Alex Loukas
Aug 04, 2014
B cell CD79A Na-ASP-2 Necator americanus SCP/TAPS antigen receptor hookworm host–pathogen interaction protein microarray Adult Ancylostomatoidea Animals Antigens Helminth B-Lymphocytes CD79 Antigens Cells Cultured Down-Regulation Helminth Proteins Hookworm Infections Host-Pathogen Interactions Humans Leukocytes Mononuclear Middle Aged Phosphatidylinositol 3-Kinases Pre-B Cell Receptors Protein Array Analysis Proteome RNA Messenger Recombinant Proteins Signal Transduction Transcription Genetic Up-Regulation src-Family Kinases
The Strange Use of דגל in Song of Songs 5
JL Andruska
May 16, 2017
The use of the word דגל in the Song of Songs 5:10 has caused considerable confusion among commentators. Most occurrences of the word in the Song are thought to be related to an army or host carrying banners, except in 5:10...
Computing the quasinormal modes and eigenfunctions for the Teukolsky equation using horizon penetrating, hyperboloidally compactified coordinates
JL Ripley
Jul 08, 2022
We study the quasinormal mode eigenvalues and eigenfunctions for the
Teukolsky equation in a horizon penetrating, hyperboloidally compactified
(HPHC) coordinate system. Following earlier work by Zengino\u{g}lu
(arXiv:1102.2451)...
Filopodia and their links with membrane traffic and cell adhesion.
JL Gallop
Dec 09, 2019
Filopodia are dynamic, narrow, plasma membrane protrusions filled with bundled actin filaments. Fresh actin monomers are incorporated at the tips furthest away from the cell body, where barbed end polymerases such as formins and...
Geometry driven type II higher dimensional blow-up for the critical heat equation
We consider the problem vt=Δv+|v|p−1vin Ω×(0,T),v=0on ∂Ω×(0,T),v>0in Ω×(0,T). In a domain Ω⊂Rd, d≥7 enjoying special symmetries, we find the first example of a solution with type II blow-up...
Geometry driven type II higher dimensional blow-up for the critical heat equation
We consider the problem vt=Δv+|v|p−1vin Ω×(0,T),v=0on ∂Ω×(0,T),v>0in Ω×(0,T). In a domain Ω⊂Rd, d≥7 enjoying special symmetries, we find the first example of a solution with type II blow-up...
Lipid metabolism in terminal erythropoiesis.
In this issue of Blood, Huang et al have provided evidence that altered lipid metabolism is critical for terminal erythropoiesis. A key role is proposed for the PHOSPHO1 gene product, a phosphocholine phosphatase. PHOSPHO1...
Machine learning for target discovery in drug development.
Chemical probes Chemical proteomics Drug Discovery Machine Learning target identification Antineoplastic Agents Computer Simulation Drug Evaluation Preclinical Humans lipoxygenase Machine Learning Molecular Targeted Therapy Naphthoquinones Pentacyclic Triterpenes Proteomics Receptors Cannabinoid Sesquiterpenes Sesquiterpenes Guaiane Transient Receptor Potential Channels
Novel application of internal obturator and semitendinosus muscle flaps for rectal wall repair or reinforcement.
Internal obturator and/or semitendinosus muscle flaps were used to reinforce primary appositional rectal wall repair in three dogs and one cat in this case series. All three dogs incurred rectal wall compromise during surgical...
EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells
B Krusche, C Ottone, MP Clements, E Johnstone, K Goetsch, L Huang, SG Mota, K Khadayate, A Ashraf, T Davies, V De Paola, P Singh, F Roncaroli, SM Pollard, JL Martinez-Torrecuadrada, P Bertone, S Parrinello
Sep 27, 2017
Microstructural alterations in the onychomycotic and psoriatic nail
E Cutrin Gomez, S. Anguiano Igea, Maria Delgado-Charro, JL Gomez Amoza, FJ Otero Espinar
Jul 31, 2018
Despite the important nail alterations caused by onychomycosis and psoriasis few studies have characterized the microstructure of the diseased nail plate and the diffusion and penetration of drugs through this altered...
Ciclopirox Clobetasol propionate Nail onychomycosis Porosity psoriasis /dk/atira/pure/subjectarea/asjc/1300/1305 name=Biotechnology /dk/atira/pure/subjectarea/asjc/3000/3003 name=Pharmaceutical Science /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Transcription of the apicoplast genome
Many members of the Apicomplexa contain a remnant chloroplast, known as an apicoplast. The apicoplast encodes numerous genes, and loss of the organelle is lethal. Here, we present a summary of what is known about apicoplast...
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