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Results: 210
Developmental clock and mechanism of de novo polarization of the mouse embryo.
Meng Zhu, Jake Cornwall-Scoones, Peizhe Wang, Charlotte E Handford, Jie Na, Matt Thomson, Magdalena Zernicka-Goetz
Mar 02, 2021
Embryo polarization is critical for mouse development; however, neither the regulatory clock nor the molecular trigger that it activates is known. Here, we show that the embryo polarization clock reflects the onset of zygotic...
Actins Animals Biological Clocks Blastocyst Cell Differentiation Cell Polarity Cytoskeletal Proteins DNA-Binding Proteins Embryonic Development Female Gene Knockdown Techniques Mice Mice Inbred C57BL Muscle Proteins RNA Interference Transcription Factor AP-2 Transcription Factors rhoA GTP-Binding Protein
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension.
Min Bao, Jake Cornwall-Scoones, Estefania Sanchez-Vasquez, Dong-Yuan Chen, Joachim De Jonghe, Shahriar Shadkhoo, Florian Hollfelder, Matt Thomson, David M Glover, Magdalena Zernicka-Goetz
Oct 15, 2022
Mammalian embryos sequentially differentiate into trophectoderm and an inner cell mass, the latter of which differentiates into primitive endoderm and epiblast. Trophoblast stem (TS), extraembryonic endoderm (XEN) and embryonic...
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension.
Min Bao, Jake Cornwall-Scoones, Estefania Sanchez-Vasquez, Dong-Yuan Chen, Joachim De Jonghe, Shahriar Shadkhoo, Florian Hollfelder, Matt Thomson, David M Glover, Magdalena Zernicka-Goetz
Sep 17, 2022
A Raman spectroscopic study of uranyl minerals from Cornwall, UK
Richard Driscoll, Daniel Wolverson, J. M. Mitchels, Jonathan Skelton, Steve Parker, Marco Molinari, Imran Khan, D Geeson, G C Allen
Jan 01, 0001
In the fields of nuclear forensics, geology and environmental science, it is important to be able to rapidly identify an unknown sample of uranyl mineral. Raman spectroscopy provides a fast, non-destructive and portable strategy...
A Raman spectroscopic study of uranyl minerals from Cornwall, UK
Richard Driscoll, Daniel Wolverson, J. M. Mitchels, Jonathan Skelton, Steve Parker, Marco Molinari, Imran Khan, D Geeson, G C Allen
Jan 01, 0001
In the fields of nuclear forensics, geology and environmental science, it is important to be able to rapidly identify an unknown sample of uranyl mineral. Raman spectroscopy provides a fast, non-destructive and portable strategy...
From ‘gender equality and ‘women’s empowerment’ to global justice
The language of ‘gender equality’ and ‘women’s empowerment’ was mobilised by feminists in the 1980s and 1990s as a way of getting women’s rights onto the international development agenda. Their efforts can be declared a...
From ‘gender equality and ‘women’s empowerment’ to global justice
The language of ‘gender equality’ and ‘women’s empowerment’ was mobilised by feminists in the 1980s and 1990s as a way of getting women’s rights onto the international development agenda. Their efforts can be declared a...
Learning 3.0
The U.S. higher education system is struggling to adapt to the needs of modern society. Employers hire for specific skills and are increasingly looking outside of higher education degrees as those degrees fail to deliver needed...
Higher Education Education Higher Education Social Sciences and Humanities Library and Information Science
Published by: IGI Global Scientific Publishing
The Grizzly, December 5, 2019
Kevin Leon, Kim Corona, Madison Rodak, Jenni Berrios, Garrett Bullock, Emma Kramer, Thomas Garlick
Jan 01, 0001
Ursinus Cancels Swimming Seasons After Hazing Investigation Students Detail Harassment on Main Street Summer Internship Tips with CPD Get to Know: Spring Break Service Trip Opinion: Ursinus' Judicial System is Broken Q&A...
Ursinus College Collegeville Pennsylvania newspaper Swimming hazing campus safety Sexual Harassment Main Street career planning Habitat for Humanity Football Jake McCain Basketball Aliyah Stephens cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Grizzly, April 9, 2020
Faculty Adjust to the Zoom Life Center for Writing and Speaking Goes Online Study Abroad Programs From all Around the World get Cancelled - and it Hurts COVID Infects Ursinus' Record Books Lazer's Historic Start Cut Short
Ursinus College Collegeville Pennsylvania newspaper covid-19 coronavirus online learning Talia Argondezzi study abroad Alex Mumme Dom Fiorentino Bobby McClure softball Heather Lazer cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Hard-sphere interactions in velocity jump models
Group-level behaviour of particles undergoing a velocity jump process with hard-sphere interactions is investigated. We derive N-particle transport equations that include the possibility of collisions between particles and apply...
Problematizing public engagement within public pedagogy research and practice
In this article, we explore issues related to how scholars attempt to enact public pedagogy (i.e. doing ‘public engagement’ work) and how they research public pedagogy (i.e. framing and researching artistic and activist...
An AGTR1 Variant Worsens Nonalcoholic Fatty Liver Disease and the Metabolic Syndrome
Nonalcoholic fatty liver disease and hypertension are closely related but there has been little genetic evidence to link them. In this issue, Musso et al. provide evidence that a common variant in AGTR1 (A1166C) is associated...
The Impact of BPA, BPS, and BPF on Cathepsin Activity and Metastasis of MCF-7 Breast Cancer Cells
Jake C Lachowicz
Jan 01, 0001
In the twenty-first century, plastic is a major product we use throughout our daily lives. One of the main components that is used to create and harden some plastics is a compound called bisphenol A (BPA). It is found widely in...
Cathepsins metastasis Breast Cancer BPF BPS BPA plastic Biochemistry Biochemistry, Biophysics, and Structural Biology Life Sciences Molecular Biology
Published by: Ursinus College
Deprotection, Purification, and Characterization of Potential Small Molecule Methyltransferase Inhibitors
John Jake Sasso
Jan 01, 0001
Methyltransferases are a large class of enzymes that catalyze the transfer of methyl groups to various protein substrates. This reaction is observed in numerous cellular processes, including the regulation of gene expression...
Published by: Ursinus College
Board Game Pedagogy
Annotated game rules for a film history board game as well as all cards designed for the project.
film History Education Board Games pedagogy communication Educational Methods game design Higher Education Other Film and Media Studies Other History of Art, Architecture, and Archaeology
Published by: Ursinus College
The Effects of Bisphenol A Structural Analogs on the Metastasis and Cathepsin Activity of MCF-7 Breast Cancer Cells
Jake C Lachowicz
Jan 01, 0001
Although different in practical use, water bottles, thermal receipts, and food cans all have one thing in common. All of these items have the possibility of containing bisphenols. Bisphenols are synthetic chemicals used in the...
bisphenols Breast Cancer Cathepsins metastasis Migration Estrogen Biochemistry, Biophysics, and Structural Biology Life Sciences
Published by: Ursinus College
The Grizzly, March 26, 2020
Seniors Sound Off on Ursinus' Switch to Online Classes The Arts: A Casualty to Come? "Spoken Word" Course Speaks Loudly Ursinus Seniors' Careers End Abruptly Lacrosse Dominates, Briefly
Ursinus College Collegeville Pennsylvania newspaper covid-19 coronavirus online learning Nzadi Keita lacrosse baseball softball cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Design and Synthesis of Small Molecule Inhibitors Using Nucleophilic Substitution
John Jake Sasso
Jan 01, 0001
The goal of this project was to design and synthesize small molecule inhibitors using nucleophilic substitution, reductive amination, tosylation, debenzylation, and deprotection reactions.
Published by: Ursinus College
Too hard, too easy, or just right? The effects of context on effort and boredom aversion
Despite people’s general desire to avoid cognitive effort, there is a limit to our parsimony: boredom, a state defined by a lack of successful mental engagement, is found to be similarly aversive. The work presented here...
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