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NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K. Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jörn M. Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D’Alessio, Nicola Personeni, Lorenza Rimassa, Ann K. Daly, Bernhard Scheiner, Katharina Pomej, Martha M. Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jörg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rössler, Alexander Siebenhüner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G. Augustin, Adrian Billeter, Beat Müller-Stich, Hiroto Kikuchi, Dan G. Duda, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E. Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U. Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N. Marche, Thomas Decaens, David J. Pinato, Roland Rad, Joachim C. Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M. Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M. Llovet, Mathias Heikenwalder
Apr 14, 2021
Abstract: Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based...
Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.
Carmen Rubio, Marta Puerto, Juan J García-Rodríquez, Van B Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M Gribble, Frank Reimann, Luis G Guijarro, Jose M Carrascosa, Ángela M Valverde
May 05, 2020
OBJECTIVE:Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase...
Published by: Molecular metabolism
NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jörn M Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D'Alessio, Nicola Personeni, Lorenza Rimassa, Ann K Daly, Bernhard Scheiner, Katharina Pomej, Martha M Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jörg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rössler, Alexander Siebenhüner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G Augustin, Adrian Billeter, Beat Müller-Stich, Hiroto Kikuchi, Dan G Duda, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N Marche, Thomas Decaens, David J Pinato, Roland Rad, Joachim C Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M Llovet, Mathias Heikenwalder
May 05, 2021
Hepatocellular carcinoma (HCC) can have viral or non-viral causes1-5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of...
Random-settlement arbitration and the generalized Nash solution:
We study bilateral bargaining á la Nash (Econometrica 21:128–140, 1953) but where players face two sources of uncertainty when demands are mutually incompatible. First, there is complete breakdown of negotiations with players...
Random-settlement arbitration and the generalized Nash solution:
We study bilateral bargaining á la Nash (Econometrica 21:128–140, 1953) but where players face two sources of uncertainty when demands are mutually incompatible. First, there is complete breakdown of negotiations with players...
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
Language Learning Through Zoom
Jonathan White
Jan 01, 2024
Attributable to the COVID pandemic, Zoom has become one of most widely used digital tools for online interaction. Schools and universities had to transition to wholly online teaching, and Zoom was one of the platforms used for...
Published by: IGI Global Scientific Publishing
On Distributed Scheduling of Flexible Demand and Nash Equilibria in the Electricity Market
This paper presents a novel game theory approach for large-scale deployment of price-responsive electrical appliances. In the proposed distributed control scheme, each appliance independently schedules its power consumption on...
IPR Policy Brief - The cost of binge drinking in the UK
Much is known about the effects and costs of sustained heavy drinking, such as the increased risk of chronic disease and injury to individuals, the damage to social relationships and the additional burden on public services...
Published by: University of Bath
Correction to
Jonathan M Lawton, Mariam Habib, Bingkui Ma, Roger A Brooks, Serena M Best, Andrew L Lewis, Neil Rushton, William Bonfield
Jun 11, 2018
The article "The effect of cationically modified phosphorylcholine polymers on human osteoblasts in vitro and their effect on bone formation in vivo", written by Jonathan M. Lawton, Mariam Habib, Bingkui Ma, Roger A. Brooks...
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
Elizabeth K Speliotes, Laura M Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J Kim, Cameron D Palmer, Vilmundur Gudnason, Gudny Eiriksdottir, Melissa E Garcia, Lenore J Launer, Michael A Nalls, Jeanne M Clark, Braxton D Mitchell, Alan R Shuldiner, Johannah L Butler, Marta Tomas, Udo Hoffmann, Shih-Jen Hwang, Joseph M Massaro, Christopher J O'Donnell, Dushyant V Sahani, Veikko Salomaa, Eric E Schadt, Stephen M Schwartz, David S Siscovick, NASH CRN, GIANT Consortium, MAGIC Investigators, Benjamin F Voight, J Jeffrey Carr, Mary F Feitosa, Tamara B Harris, Caroline S Fox, Albert V Smith, WH Linda Kao, Joel N Hirschhorn, Ingrid B Borecki, GOLD Consortium
Jan 23, 2018
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide...
Adaptor Proteins Signal Transducing Adult Aged Aged 80 and over Blood Glucose Case-Control Studies Chondroitin Sulfate Proteoglycans Cohort Studies Fatty Liver Genome-Wide Association Study Humans Insulin Lectins C-Type LIPASE Male Membrane Proteins Middle Aged Mutation Missense Nerve Tissue Proteins Neurocan non-alcoholic fatty liver disease Polymorphism Single Nucleotide Quantitative Trait Loci Tomography X-Ray Computed
On Distributed Scheduling of Flexible Demand and Nash Equilibria in the Electricity Market
This paper presents a novel game theory approach for large-scale deployment of price-responsive electrical appliances. In the proposed distributed control scheme, each appliance independently schedules its power consumption on...
Focality and Asymmetry in Multi-battle Contests
This article examines the influence of focality in Colonel Blotto games with a lottery contest success function, where the equilibrium is unique and in pure strategies. We hypothesize that the salience of battlefields affects...
Broodmother
This chapter asks, “What is it like to be a public school teacher in a school that doesn't allow for adequate bathroom breaks?” Using van Manen's interpretive phenomenological methodology, the authors analyzed interviews from...
Research Methods Education Curriculum Development and Instructional Design Library and Information Science Social Sciences and Humanities
Published by: IGI Global Scientific Publishing
Focality and Asymmetry in Multi-battle Contests
This article examines the influence of focality in Colonel Blotto games with a lottery contest success function, where the equilibrium is unique and in pure strategies. We hypothesize that the salience of battlefields affects...
Rapid vertical exchange at fronts in the Northern Gulf of Mexico.
Lixin Qu, Leif N Thomas, Aaron F Wienkers, Robert D Hetland, Daijiro Kobashi, John R Taylor, Fucent Hsuan Wei Hsu, Jennifer A MacKinnon, R Kipp Shearman, Jonathan D Nash
Sep 26, 2022
Over the Texas-Louisiana Shelf in the Northern Gulf of Mexico, the eutrophic, fresh Mississippi/Atchafalaya river plume isolates saltier waters below, supporting the formation of bottom hypoxia in summer. The plume also...
Rapid vertical exchange at fronts in the Northern Gulf of Mexico.
Lixin Qu, Leif N Thomas, Aaron F Wienkers, Robert D Hetland, Daijiro Kobashi, John R Taylor, Fucent Hsuan Wei Hsu, Jennifer A MacKinnon, R Kipp Shearman, Jonathan D Nash
Oct 28, 2022
Over the Texas-Louisiana Shelf in the Northern Gulf of Mexico, the eutrophic, fresh Mississippi/Atchafalaya river plume isolates saltier waters below, supporting the formation of bottom hypoxia in summer. The plume also...
Unmet needs in pediatric NAFLD research
Pediatric nonalcoholic fatty liver disease (NAFLD) is common disorder that has complex pathophysiology and unquantified clinical significance. Though there have been major advances in the field, there is much yet to be...
Nonalcoholic fatty liver disease fatty liver disease hepatology Microbiome Pediatrics Adolescent Biomedical Research Cardiovascular Diseases Child Child Preschool Dysbiosis Gastrointestinal Microbiome Host Microbial Interactions Humans Infant Infant Newborn Metabolic Syndrome non-alcoholic fatty liver disease Risk Assessment
Using VR for Collaborative Learning
Although virtual reality (VR) has been technologically possible for decades, both logistical and pedagogical limitations have slowed progress relating to collaborating with others in virtual reality environments. This article...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Towards an E-Learning Support Strategy for the Retail Sector in South Africa
E-learning is of increasing importance in delivering flexible and distributed programmes for workforce skill development such as induction, product knowledge, systems compliance, and customer service. This research consists of a...
Published by: IGI Global Scientific Publishing
IPR Policy Brief - Incentives and children's dietary choices:
There is a growing interest from both academics and policy makers in the use of incentives to change health behaviours; especially of children.
In October 2011, Michèle Belot (University of Edinburgh), Jonathan James...
In October 2011, Michèle Belot (University of Edinburgh), Jonathan James...
Published by: University of Bath
IPR Policy Brief - Incentives and children's dietary choices:
There is a growing interest from both academics and policy makers in the use of incentives to change health behaviours; especially of children.
In October 2011, Michèle Belot (University of Edinburgh), Jonathan James...
In October 2011, Michèle Belot (University of Edinburgh), Jonathan James...
Published by: University of Bath
Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function.
Gretchen Wolff, Minako Sakurai, Amit Mhamane, Maria Troullinaki, Adriano Maida, Ioannis K Deligiannis, Kelvin Yin, Peter Weber, Jakob Morgenstern, Annika Wieder, Yun Kwon, Revathi Sekar, Anja Zeigerer, Michael Roden, Matthias Blüher, Nadine Volk, Tanja Poth, Thilo Hackert, Lena Wiedmann, Francesca De Angelis Rigotti, Juan Rodriguez-Vita, Andreas Fischer, Rajesh Mukthavaram, Pattraranee Limphong, Kiyoshi Tachikawa, Priya Karmali, Joseph Payne, Padmanabh Chivukula, Bilgen Ekim-Üstünel, Celia P Martinez-Jimenez, Julia Szendrödi, Peter Nawroth, Stephan Herzig
May 09, 2022
OBJECTIVE: Fibrotic organ responses have recently been identified as long-term complications in diabetes. Indeed, insulin resistance and aberrant hepatic lipid accumulation represent driving features of progressive non-alcoholic...
Education Majors Capture Top Academic Award at Graduation
Winthrop University
Jan 01, 0001
Seniors Sarah Mackenzie Helmsand Jonathan Derek Logan received the Tillman Award at Winthrop University's spring Commencement exercises on May 9 at Winthrop Coliseum. Acting President Debra Boyd presented the two the Tillman...
Published by: Winthrop University
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