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The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy
The efficacy of triple drug therapy for HIV-1 infection encourages its early use to prevent damage to the immune system. We monitored the effects of such therapy on 12 patients with 14-75-mo histories of minimal disease, i.e....
Published by: Rockefeller University
Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus
Atraumatic application of attenuated SIVmac23?nef vaccine to the tonsils of rhesus macaques provided protection against challenge 26 weeks later with infectious SIVmac251 applied through this route. Early events at the mucosal...
cell maturation immune response Lymphoid Tissue mucosa associated lymphoid tissue lymphoma pathogenicity Simian Immunodeficiency Virus t lymphocyte activation virus transmission
Published by: Rockefeller University
Increased macrophage infection upon subcutaneous inoculation of rhesus macaques with simian immunodeficiency virus-loaded dendritic cells or T cells but not with cell-free virus
Information on the establishment of immunodeficiency virus infection through transmission of infected cells is sparse. Dendritic cells (DCs) and T cells may be central to the onset and subsequent spread of infection following...
dendritic cell Immunohistochemistry In Situ Hybridization Macaca macrophage Simian Immunodeficiency Virus T lymphocyte
Published by: Rockefeller University
A cross-cultural exploration of children's perceptions of wellbeing
There is a growing body of literature on children's wellbeing. However, historically, focus has been on adults’ perspectives, leading to adult-centric views of wellbeing. Although recent years have witnessed an increase in...
Serious physical assault and subsequent risk for rehospitalization in individuals with severe mental illness
Abstract: Background: Victimization is associated with worse social and clinical outcomes of individuals with severe mental illness (SMI). A relapse of SMI may be one of the clinical consequences of assaultive trauma. As far as...
Serious physical assault and subsequent risk for rehospitalization in individuals with severe mental illness
BACKGROUND: Victimization is associated with worse social and clinical outcomes of individuals with severe mental illness (SMI). A relapse of SMI may be one of the clinical consequences of assaultive trauma. As far as we know...
A cross-cultural exploration of children's perceptions of wellbeing
There is a growing body of literature on children's wellbeing. However, historically, focus has been on adults’ perspectives, leading to adult-centric views of wellbeing. Although recent years have witnessed an increase in...
Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains.
Elissavet Kentepozidou, Sarah J Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T Odom, Maša Roller, Paul Flicek
Feb 08, 2020
BACKGROUND:CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation...
Published by: Genome biology
Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains.
Elissavet Kentepozidou, Sarah J Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T Odom, Maša Roller, Paul Flicek
Jan 31, 2020
BACKGROUND: CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation...
Single-Molecule Light-Sheet Imaging of Suspended T Cells.
Aleks Ponjavic, James McColl, Alexander R Carr, Ana Mafalda Santos, Klara Kulenkampff, Anna Lippert, Simon J Davis, David Klenerman, Steven F Lee
Apr 11, 2019
Adaptive immune responses are initiated by triggering of the T cell receptor. Single-molecule imaging based on total internal reflection fluorescence microscopy at coverslip/basal cell interfaces is commonly used to study this...
Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.
Sarah Leigh-Brown, Angela Goncalves, David Thybert, Klara Stefflova, Stephen Watt, Paul Flicek, Alvis Brazma, John C Marioni, Duncan T Odom
Jan 31, 2020
Phenotypic differences between species are driven by changes in gene expression and, by extension, by modifications in the regulation of the transcriptome. Investigation of mammalian transcriptome divergence has been restricted...
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients.
Klara Kulenkampff, Derya Emin, Roxine Staats, Yu P Zhang, Laila Sakhnini, Antonina Kouli, Oded Rimon, Evgeniia Lobanova, Caroline H Williams-Gray, Francesco A Aprile, Pietro Sormanni, David Klenerman, Michele Vendruscolo
Jan 22, 2023
Misfolded α-synuclein oligomers are closely implicated in the pathology of Parkinson's disease and related synucleinopathies. The elusive nature of these aberrant assemblies makes it challenging to develop quantitative methods...
Rapid turnover of long noncoding RNAs and the evolution of gene expression.
Claudia Kutter, Stephen Watt, Klara Stefflova, Michael D Wilson, Angela Goncalves, Chris P Ponting, Duncan T Odom, Ana C Marques
Jan 31, 2020
A large proportion of functional sequence within mammalian genomes falls outside protein-coding exons and can be transcribed into long RNAs. However, the roles in mammalian biology of long noncoding RNA (lncRNA) are not well...
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
Elena Sanna, Margarida Rodrigues, Steven G Fagan, Timothy S Chisholm, Klara Kulenkampff, David Klenerman, Maria Grazia Spillantini, Franklin I Aigbirhio, Christopher A Hunter
Aug 14, 2021
A key process in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is the aggregation of proteins to produce fibrillary aggregates with a cross β-sheet structure, amyloid. The development...
Published by: Chemical science
The gut microbial metabolic capacity of microbiome-humanized vs. wild type rodents reveals a likely dual role of intestinal bacteria in hepato-intestinal schistosomiasis.
Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation.
Tina Ghelani, Marc Escher, Ulrich Thomas, Klara Esch, Janine Lützkendorf, Harald Depner, Marta Maglione, Pierre Parutto, Scott Gratz, Tanja Matkovic-Rachid, Stefanie Ryglewski, Alexander M Walter, David Holcman, Kate O'Connor Giles, Martin Heine, Stephan J Sigrist
Mar 20, 2023
At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca2+ channels (VGCCs). While AZs can...
Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells.
Ide Smets, Barnaby Fiddes, Josselyn E Garcia-Perez, Di He, Klara Mallants, Wenjia Liao, James Dooley, George Wang, Stephanie Humblet-Baron, Bénédicte Dubois, Alastair Compston, Joanne Jones, Alasdair Coles, Adrian Liston, Maria Ban, An Goris, Stephen Sawcer
May 25, 2018
The increasing evidence supporting a role for B cells in the pathogenesis of multiple sclerosis prompted us to investigate the influence of known susceptibility variants on the surface expression of co-stimulatory molecules in...
Overexpression of the WAPO-A1 gene increases the number of spikelets per spike in bread wheat.
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