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The Edgeworth Cube
Social peace is an asset to every society. Its absence endangers the well-being and the safety of the population and the stability of states. In order to better understand the interdependencies of poverty, social peace and...
Published by: IGI Global Scientific Publishing
Younger supervisors, older subordinates
Younger employees are often promoted into supervisory positions in which they then manage older subordinates. Do companies benefit or suffer when supervisors and subordinates have inverse age differences? In this study, we...
A Modular Bio-Platform Based on a Versatile Supramolecular Multi-Enzyme Complex Directly Attached to Graphene
Abeer Alshammari, Mareike G. Posner, Abhishek Upadhyay, Frank Marken, Stefan Bagby, Adelina Ilie
Aug 17, 2016
Developing generic strategies for building adaptable or multi-functional bio-platforms is challenging, in particular because protein immobilization onto surfaces often causes loss of protein function and multi-functionality...
Analysis of two choir outbreaks acting in concert to characterize long- range transmission risks through SARS-CoV-2, Berlin, Germany, 2020.
Felix Reichert, Oliver Stier, Anne Hartmann, Claudia Ruscher, Annika Brinkmann, Marica Grossegesse, Markus Neumann, Dirk Werber, Marius Hausner, Mareike Kunze, Bettina Weiß, Janine Michel, Andreas Nitsche, Matthias An der Heiden, Martin Kriegel, Victor Max Corman, Terry Carleton Jones, Christian Drosten, Tobias Brommann, Udo Buchholz
Nov 17, 2022
A Modular Bio-Platform Based on a Versatile Supramolecular Multi-Enzyme Complex Directly Attached to Graphene
Abeer Alshammari, Mareike G. Posner, Abhishek Upadhyay, Frank Marken, Stefan Bagby, Adelina Ilie
Aug 17, 2016
Developing generic strategies for building adaptable or multi-functional bio-platforms is challenging, in particular because protein immobilization onto surfaces often causes loss of protein function and multi-functionality...
Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea
Kirill Borziak, Mareike Posner, Abhishek Upadhyay, Michael Danson, Stefan Bagby, Stephen Dorus
Jan 28, 2014
Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can
metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic...
metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic...
A peptide from the staphylococcal protein Efb binds P-selectin and inhibits the interaction of platelets with leukocytes
Stuart Wallis, Nina Wolska, Hanna Englert, Mareike Posner, Abhishek Upadhyay, Thomas Renne, Ian Eggleston, Stefan Bagby, Giordano Pula
Mar 31, 2022
Aims
P-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have shown previously that the N-terminal domain of S. aureus extracellular fibrinogen-binding protein (Efb) binds to...
P-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have shown previously that the N-terminal domain of S. aureus extracellular fibrinogen-binding protein (Efb) binds to...
Chronic irradiation of human cells reduces histone levels and deregulates gene expression.
Donna J Lowe, Mareike Herzog, Thorsten Mosler, Howard Cohen, Sarah Felton, Petra Beli, Ken Raj, Yaron Galanty, Stephen P Jackson
Mar 13, 2020
Over the past decades, there have been huge advances in understanding cellular responses to ionising radiation (IR) and DNA damage. These studies, however, were mostly executed with cell lines and mice using single or multiple...
Published by: Scientific reports
Detection of functional protein domains by unbiased genome-wide forward genetic screening.
Mareike Herzog, Fabio Puddu, Julia Coates, Nicola Geisler, Josep V Forment, Stephen P Jackson
Aug 03, 2018
Establishing genetic and chemo-genetic interactions has played key roles in elucidating mechanisms by which certain chemicals perturb cellular functions. In contrast to gene disruption/depletion strategies to identify mechanisms...
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence.
Hepatocyte nuclear factor-1β (HNF1β) Importin-α Isothermal titration calorimetry Nuclear import pathway Nuclear localisation signal sequence (NLS) Site-directed mutagenesis X-ray crystallography Active Transport Cell Nucleus Animals Binding Sites Cell Line Tumor Cell Nucleus Crystallography X-Ray HEK293 Cells Hepatocyte Nuclear Factor 1-beta Humans Mice Models Molecular Nuclear Localization Signals Protein Binding Protein Conformation alpha-Helical Sequence Analysis Protein Xenopus Proteins Xenopus laevis alpha Karyopherins
Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea
Kirill Borziak, Mareike Posner, Abhishek Upadhyay, Michael Danson, Stefan Bagby, Stephen Dorus
Jan 28, 2014
Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can
metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic...
metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic...
A peptide from the staphylococcal protein Efb binds P-selectin and inhibits the interaction of platelets with leukocytes
Stuart Wallis, Nina Wolska, Hanna Englert, Mareike Posner, Abhishek Upadhyay, Thomas Renne, Ian Eggleston, Stefan Bagby, Giordano Pula
Mar 31, 2022
Aims
P-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have shown previously that the N-terminal domain of S. aureus extracellular fibrinogen-binding protein (Efb) binds to...
P-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have shown previously that the N-terminal domain of S. aureus extracellular fibrinogen-binding protein (Efb) binds to...
Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin
Abigail H. Davies, Joanna McGlashan, Mareike G. Posner, April K. Roberts, Clifford C. Shone, K. Ravi Acharya
Dec 01, 2016
Clostridium difficile binary toxin (CDT) is an ADP-ribosyltransferase which is linked to enhanced pathogenesis of C. difficile strains. CDT has dual function: domain a (CDTa) catalyses the ADP-ribosylation of actin (enzymatic...
ADP-ribosylation Clostridium difficile binary toxin enzymology Mutagenesis /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1304 name=Biophysics /dk/atira/pure/subjectarea/asjc/1300/1307 name=Cell Biology /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology
Trajectory and uniqueness of mutational signatures in yeast mutators.
Sophie Loeillet, Mareike Herzog, Fabio Puddu, Patricia Legoix, Sylvain Baulande, Stephen P Jackson, Alain G Nicolas
Aug 28, 2020
The acquisition of mutations plays critical roles in adaptation, evolution, senescence, and tumorigenesis. Massive genome sequencing has allowed extraction of specific features of many mutational landscapes but it remains...
Pol zeta dynamics of mutation accumulation Loss of Heterozygosity mutational profiles mutator genes Acetyltransferases BRCA1 Protein BRCA2 Protein Breast Neoplasms Carcinogenesis DNA Damage DNA-Directed DNA Polymerase Diploidy Female Flap Endonucleases Genome Fungal Humans Loss of Heterozygosity Membrane Proteins Mutation Peroxiredoxins Rad51 Recombinase Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins whole genome sequencing
High proliferation and delamination during skin epidermal stratification.
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D Simons, Hisham Bazzi
Jul 05, 2021
Adolescent Adult Aged Animals Asymmetric cell division Cell Differentiation Cell Proliferation Centrosome Child Child Preschool Embryo Mammalian epidermis Female Hair Follicle Humans Keratinocytes Male Mice Mice Knockout Middle Aged Models Biological Skin Physiological Phenomena Spindle Apparatus Time-Lapse Imaging Tumor Suppressor Protein p53 Tumor Suppressor p53-Binding Protein 1 Ubiquitin Thiolesterase Young Adult
Post-translational modification in the archaea
Mareike G. Posner, Abhishek Upadhyay, Susan Crennell, Andrew J. A. Watson, Stephen Dorus, Michael J. Danson, Stefan Bagby
Jan 15, 2013
Lipoylation, the covalent attachment of lipoic acid to 2-oxoacid dehydrogenase multi-enzyme complexes, is essential for metabolism in aerobic bacteria and eukarya. In Escherichia coli, lipoylation is catalysed by lipoate protein...
Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.
Yun Song, Lisbeth Dagil, Louise Fairall, Naomi Robertson, Mingxuan Wu, TJ Ragan, Christos G Savva, Almutasem Saleh, Nobuhiro Morone, Micha BA Kunze, Andrew G Jamieson, Philip A Cole, D Flemming Hansen, John WR Schwabe
Feb 28, 2020
The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase...
CoREST complex HDAC1 KDM1A LSD1 RCOR1 Histone deacetylase lysine demethylase nucleosome Acetylation Amino Acid Sequence Animals Co-Repressor Proteins Cryoelectron Microscopy Demethylation HEK293 Cells Histone Deacetylase 1 Histone Demethylases Humans Kinetics Models Molecular Nerve Tissue Proteins Nucleosomes Xenopus
High proliferation and delamination during skin epidermal stratification.
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D Simons, Hisham Bazzi
Jun 29, 2021
The development of complex stratified epithelial barriers in mammals is initiated from single-layered epithelia. How stratification is initiated and fueled are still open questions. Previous studies on skin epidermal...
epidermis Hair Follicle Centrosome Keratinocytes Animals Mice Knockout Humans Mice Ubiquitin Thiolesterase Cell Differentiation Cell Proliferation Models Biological Adolescent Adult Aged Middle Aged Child Child Preschool Female Male Tumor Suppressor Protein p53 Embryo Mammalian Skin Physiological Phenomena Young Adult Time-Lapse Imaging Asymmetric cell division Spindle Apparatus Tumor Suppressor p53-Binding Protein 1
Published by: Nature Communications
High proliferation and delamination during skin epidermal stratification
Mareike Damen, Lisa Wirtz, Ekaterina Soroka, Houda Khatif, Christian Kukat, Benjamin D. Simons, Hisham Bazzi
May 28, 2021
Abstract: The development of complex stratified epithelial barriers in mammals is initiated from single-layered epithelia. How stratification is initiated and fueled are still open questions. Previous studies on skin epidermal...
Chronic irradiation of human cells reduces histone levels and deregulates gene expression.
Donna J Lowe, Mareike Herzog, Thorsten Mosler, Howard Cohen, Sarah Felton, Petra Beli, Ken Raj, Yaron Galanty, Stephen P Jackson
Feb 05, 2020
Over the past decades, there have been huge advances in understanding cellular responses to ionising radiation (IR) and DNA damage. These studies, however, were mostly executed with cell lines and mice using single or multiple...
Enhanced Colorimetric Differentiation between Staphylococcus aureus and Pseudomonas aeruginosa Using a Shape-Encoded Sensor Hydrogel
Zhiyuan Jia, Lauren Gwynne, Adam C. Sedgwick, Mareike Müller, George T. Williams, Andrew Toby A. Jenkins, Tony D. James, Holger Schönherr
Jul 20, 2020
Herein, we demonstrate a combined fluorescent probe/shape-encoded hydrogel strategy for the fast, sensitive, and selective detection of bacterial species via their characteristic enzymes. A poly(vinyl alcohol) (PVA) hydrogel...
bacteria detection bacteria differentiation Biosensors Fluorescent probe Hydrogels /dk/atira/pure/subjectarea/asjc/2500/2502 name=Biomaterials /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/2700/2704 name=Biochemistry, medical
Enhanced Colorimetric Differentiation between Staphylococcus aureus and Pseudomonas aeruginosa Using a Shape-Encoded Sensor Hydrogel
Zhiyuan Jia, Lauren Gwynne, Adam C. Sedgwick, Mareike Müller, George T. Williams, Andrew Toby A. Jenkins, Tony D. James, Holger Schönherr
Jul 20, 2020
Herein, we demonstrate a combined fluorescent probe/shape-encoded hydrogel strategy for the fast, sensitive, and selective detection of bacterial species via their characteristic enzymes. A poly(vinyl alcohol) (PVA) hydrogel...
bacteria detection bacteria differentiation Biosensors Fluorescent probe Hydrogels /dk/atira/pure/subjectarea/asjc/2500/2502 name=Biomaterials /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/2700/2704 name=Biochemistry, medical
Practice-changing radiation therapy trials for the treatment of cancer
Mareike K Thompson, Philip Poortmans, Anthony J Chalmers, Corinne Faivre-Finn, Emma Hall, Robert A Huddart, Yolande Lievens, David Sebag-Montefiore, Charlotte E Coles
Oct 22, 2018
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