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Results: 296
Mammalian autophagy and the plasma membrane.
Autophagy (literally 'self-eating') is an evolutionarily conserved degradation process where cytoplasmic components are engulfed by vesicles called autophagosomes, which are then delivered to lysosomes, where their contents are...
Cell type-specific YAP1-WWTR1/TAZ transcriptional responses after autophagy perturbations are determined by levels of α-catenins (CTNNA1 and CTNNA3).
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases.
Alvin Djajadikerta, Swati Keshri, Mariana Pavel, Ryan Prestil, Laura Ryan, David C Rubinsztein
Dec 11, 2019
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lysosomes for degradation. Genetic studies have revealed extensive links between autophagy and neurodegenerative disease, and...
Vinexin contributes to autophagic decline in brain ageing across species.
So Jung Park, Rebecca A Frake, Cansu Karabiyik, Sung Min Son, Farah H Siddiqi, Carla F Bento, Peter Sterk, Mariella Vicinanza, Mariana Pavel, David C Rubinsztein
May 10, 2022
An unexpected role reversal
Abstract
In 1862, the collector Pavel Tretyakov made his second visit to Britain, and lent three paintings to the International Exhibition held in London that year. Then aged just thirty, he had...
RP Blakesley
Apr 19, 2017
Combined Learning Models Based on Constructionism Applied in Modern Learning of Biology
Iancu Mariana
Jan 01, 2019
The purpose of this research has been to identify modern and effective learning models, based on constructionism, in learning biological concepts. The author shows that the cognitive, formative, and emotional benefits, of...
Published by: IGI Global Scientific Publishing
Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis.
Mariana Pavel, Maurizio Renna, So Jung Park, Fiona M Menzies, Thomas Ricketts, Jens Füllgrabe, Avraham Ashkenazi, Rebecca A Frake, Alejandro Carnicer Lombarte, Carla F Bento, Kristian Franze, David C Rubinsztein
Sep 08, 2018
Actin Cytoskeleton Actins Acyltransferases Adaptor Proteins Signal Transducing Animals Apoptosis Autophagosomes Autophagy CapZ Actin Capping Protein Cell Count Cell Line Tumor Cell Proliferation Cell Survival Contact Inhibition Epithelial Cells Extracellular Matrix FIBROBLASTS Gene Knockdown Techniques Glucose HeLa Cells Humans Hypoxia Mice Myosin Type II Phosphoproteins Signal Transduction Transcription Factors YAP-Signaling Proteins
Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study.
There is growing interest in Phase I dose-finding studies studying several doses of more than one agent simultaneously. A number of combination dose-finding designs were recently proposed to guide escalation/de-escalation...
Design Thinking and Compliance as Drivers for Decision Support System Adoption in Agriculture
To respond to increasing demands for good agricultural practices (GAP) and food safety, governments globally are introducing stringent regulations to govern agricultural compliance that affect production, storage, and sales...
Published by: IGI Global Scientific Publishing
From Face Perception to Individual Recognition: The Missing Link
Sofia Mariana Landi
Jan 01, 0001
Recognizing other individuals is a key social aspect of our everyday lives. To recognize a familiar individual, we must establish a link between sensory inputs and a representation of that individual held in memory. In primates...
Published by: Rockefeller University
Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis.
The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life
The use of assisted reproductive technologies (ART) worldwide has led to the conception and birth of over eight million babies since being implemented in 1978. ART use is currently on the rise, given growing infertility and the...
Self-conscious emotions in patients suffering from chronic musculoskeletal pain
Objective: The role of self-conscious emotions (SCEs) including shame, guilt, humiliation and embarrassment are of increasing interest within health. Yet, little is known about SCEs in the experience of chronic pain. This...
Investigating the critical variables of azithromycin oral absorption using <i>in vitro </i>tests and PBPK Modeling
Azithromycin is an antibiotic listed in the essential list of medicines for adults and pediatrics. Conflicting evidence has been found regarding azithromycin classification according to the Biopharmaceutics classification system...
An order restricted multi-arm multi-stage clinical trial design.
One family of designs that can noticeably improve efficiency in later stages of drug development are multi-arm multi-stage (MAMS) designs. They allow several arms to be studied concurrently and gain efficiency by dropping poorly...
Right Engel-type subgroups and length parameters of finite groups
Let be an element of a finite group and let be the subgroup generated by all the right Engel values over. In the case when is soluble we prove that if, for some, the Fitting height of is equal to, then belongs to the th...
Using an Interaction Parameter in Model-Based Phase I Trials for Combination Treatments? A Simulation Study
There is growing interest in Phase I dose-finding studies studying several doses of more than one agent simultaneously. A number of combination dose-finding designs were recently proposed to guide escalation/de-escalation...
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic.
BACKGROUND: Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when...
Obstacles to detecting isoforms using full-length scRNA-seq data
Abstract: Background: Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched...
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic.
BACKGROUND: Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when...
Groups with boundedly many commutator of maximal order
By a result of Cocke and Venkataraman we know that if G is a group with at most m elements of maximal order, then is m-bounded. In this paper we consider the following related setting. Suppose G is a group with at most m...
Investigating the critical variables of azithromycin oral absorption using <i>in vitro </i>tests and PBPK Modeling
Azithromycin is an antibiotic listed in the essential list of medicines for adults and pediatrics. Conflicting evidence has been found regarding azithromycin classification according to the Biopharmaceutics classification system...
A Hybrid Hierarchical Heuristic-ACO With Local Search Applied to Travelling Salesman Problem, AS-FA-Ls
The combinatorial optimization problem is attracting research because they have a wide variety of applications ranging from route planning and supply chain optimization to industrial scheduling and the IoT. Solving such problems...
Published by: IGI Global Scientific Publishing
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