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Results: 43
A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer
A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer
Silvana Debernardi, Harrison O'Brien, Asma S Algahmdi, Nuria Malats, Grant D Stewart, Marija Plješa-Ercegovac, Eithne Costello, William Greenhalf, Amina Saad, Rhiannon Roberts, Alexander Ney, Stephen P Pereira, Hemant M Kocher, Stephen Duffy, Oleg Blyuss, Tatjana Crnogorac-Jurcevic
Nov 23, 2020
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with around 9% of patients surviving >5 years. Asymptomatic in its initial stages, PDAC is mostly diagnosed late, when already a locally...
Adult Aged Aged 80 and over Antigens Tumor-Associated Carbohydrate Biomarkers Tumor Carcinoma Pancreatic Ductal Early Detection of Cancer Europe Female Humans Lithostathine Male Middle Aged Pancreatic Neoplasms Predictive Value of Tests Reproducibility of Results Retrospective Studies Trefoil Factor-1 Urinalysis Vesicular Transport Proteins Young Adult
Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation.
Sports Tourism Products
In addition to good accommodation and sports infrastructure, Slovenia has an extremely developed system of training, testing, and rehabilitation of athletes. Slovenian athletes have always topped in various sports providing...
Published by: IGI Global Scientific Publishing
A C. elegans model for neurodegeneration in Cockayne syndrome.
Amanda FC Lopes, Katarzyna Bozek, Marija Herholz, Aleksandra Trifunovic, Matthias Rieckher, Björn Schumacher
Nov 24, 2020
Cockayne syndrome (CS) is a congenital syndrome characterized by growth and mental retardation, and premature ageing. The complexity of CS and mammalian models warrants simpler metazoan models that display CS-like phenotypes...
How health system factors influence referral decisions in patients that may have cancer
Michael Harris, Peter Frey, Magdalena Esteva, Svjetlana Gasparovic Babic, Mercè Marzo-Castillejo, Davorina Petek, Marija Petek Ster, Hans Thulesius
Jan 01, 0001
Objective: To identify the system and other non-clinical factors that may influence a General Practitioners’ decision on whether to refer a patient who may have cancer. Study design: Expert group discussion and consensus...
The route of administration, timing, duration and dose of postmenopausal hormone therapy and cardiovascular outcomes in women
Clare Oliver-Williams, Marija Glisic, Sara Shahzad, Elizabeth Brown, Cristina Pellegrino Baena, Mahmuda Chadni, Rajiv Chowdhury, Oscar H Franco, Taulant Muka
Dec 19, 2018
cardiovascular risk coronary heart disease hormone therapy Menopause Myocardial Infarction stroke venous thromboembolism Cardiovascular Diseases Estradiol Estrogen Replacement Therapy Estrogens Female Humans Menopause Middle Aged Postmenopause Progesterone Prospective Studies stroke Thrombosis venous thromboembolism
Hidden Specificities in Enzyme Catalysis
Matthias Häckh, Xavier Lucas, Marija Marolt, Peter F Leadlay, Michael Müller, Stefan Günther, Steffen Lüdeke
Feb 12, 2019
Enzymes often convert both physiological and non-physiological substrates with high stereoselectivity; yet, for some enzymes, opposite product chirality is observed. A possible explanation is the existence of hidden...
How health system factors influence referral decisions in patients that may have cancer
Michael Harris, Peter Frey, Magdalena Esteva, Svjetlana Gasparovic Babic, Mercè Marzo-Castillejo, Davorina Petek, Marija Petek Ster, Hans Thulesius
Jan 01, 0001
Objective: To identify the system and other non-clinical factors that may influence a General Practitioners’ decision on whether to refer a patient who may have cancer. Study design: Expert group discussion and consensus...
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Marija Iljina, Laura Tosatto, Minee L Choi, Jason C Sang, Yu Ye, Craig D Hughes, Clare E Bryant, Sonia Gandhi, David Klenerman
Dec 04, 2017
Association between progestin-only contraceptive use and cardiometabolic outcomes
Marija Glisic, Sara Shahzad, Stergiani Tsoli, Mahmuda Chadni, Eralda Asllanaj, Lyda Z Rojas, Elizabeth Brown, Rajiv Chowdhury, Taulant Muka, Oscar H Franco
Dec 07, 2018
Aims The association between progestin-only contraceptive (POC) use and the risk of various cardiometabolic outcomes has rarely been studied. We performed a systematic review and meta-analysis to determine the impact of POC use...
Progestogen cardiometabolic risk Contraception Hypertension Myocardial Infarction Progesterone progestin-only pill stroke Type 2 diabetes venous thromboembolism women Administration Oral Adolescent Adult Aged Cardiovascular Diseases Contraceptives Oral Hormonal Diabetes mellitus Drug Implants Female Humans Injections Middle Aged Progestins Risk Assessment Risk Factors Venous Thromboembolism Young Adult
Quantifying Co-Oligomer Formation by α-Synuclein.
Marija Iljina, Alexander J Dear, Gonzalo A Garcia, Suman De, Laura Tosatto, Patrick Flagmeier, Daniel R Whiten, Thomas CT Michaels, Daan Frenkel, Christopher M Dobson, Tuomas PJ Knowles, David Klenerman
Dec 07, 2018
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A. Lazarus, Mona Shehata, Bruno M. Simões, Alice R. Greenhalgh, Sacha J. Howell, Robert B. Clarke, Carlos Caldas, Timotheus Y. F. Halim, John C. Marioni, Walid T. Khaled
Mar 09, 2021
Abstract: It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little...
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
Mathew H Horrocks, Steven F Lee, Sonia Gandhi, Nadia K Magdalinou, Serene W Chen, Michael J Devine, Laura Tosatto, Magnus Kjaergaard, Joseph S Beckwith, Henrik Zetterberg, Marija Iljina, Nunilo Cremades, Christopher M Dobson, Nicholas W Wood, David Klenerman
Jan 26, 2016
Guidelines for the functional annotation of microRNAs using the Gene Ontology.
Rachael P Huntley, Dmitry Sitnikov, Marija Orlic-Milacic, Rama Balakrishnan, Peter D'Eustachio, Marc E Gillespie, Doug Howe, Anastasia Z Kalea, Lars Maegdefessel, David Osumi-Sutherland, Victoria Petri, Jennifer R Smith, Kimberly Van Auken, Valerie Wood, Anna Zampetaki, Manuel Mayr, Ruth C Lovering
Jan 22, 2016
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
Marija Iljina, Gonzalo A Garcia, Mathew H Horrocks, Laura Tosatto, Minee L Choi, Kristina A Ganzinger, Andrey Y Abramov, Sonia Gandhi, Nicholas W Wood, Nunilo Cremades, Christopher M Dobson, Tuomas PJ Knowles, David Klenerman
Feb 04, 2016
Dysregulated Antibody, Natural Killer Cell and Immune Mediator Profiles in Autoimmune Thyroid Diseases.
Tiphaine C Martin, Kristina M Ilieva, Alessia Visconti, Michelle Beaumont, Steven J Kiddle, Richard JB Dobson, Massimo Mangino, Ee Mun Lim, Marija Pezer, Claire J Steves, Jordana T Bell, Scott G Wilson, Gordan Lauc, Mario Roederer, John P Walsh, Tim D Spector, Sophia N Karagiannis
Mar 10, 2020
Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans.
Marija Zaric, Arianna Marini, Carolyn M Nielsen, Gaurav Gupta, David Mekhaiel, Thao P Pham, Sean C Elias, Iona J Taylor, Hans de Graaf, Ruth O Payne, Yuanyuan Li, Sarah E Silk, Chris Williams, Adrian VS Hill, Carole A Long, Kazutoyo Miura, Sumi Biswas
Nov 25, 2021
Plasmodium falciparum transmission-blocking vaccines (TBVs) targeting the Pfs25 antigen have shown promise in mice but the same efficacy has never been achieved in humans. We have previously published pre-clinical data related...
CD4+ P. falciparum Pfs25 transmission blocking vaccine Adolescent Adult Animals Antibodies Protozoan B-Lymphocytes CD4-Positive T-Lymphocytes Cells Cultured Disease Models Animal Epitopes Female Humans Immunity Humoral Immunogenicity Vaccine Malaria Vaccines Malaria Falciparum Male Mice Mice Inbred BALB C Middle Aged Plasmodium falciparum Protozoan Proteins Recombinant Proteins Species Specificity Vaccination Young Adult
Electrocardiographic abnormalities in Chagas disease in the general population
Lyda Z Rojas, Marija Glisic, Laura Pletsch-Borba, Luis E Echeverría, Wichor M Bramer, Arjola Bano, Najada Stringa, Asija Zaciragic, Bledar Kraja, Eralda Asllanaj, Rajiv Chowdhury, Carlos A Morillo, Oscar L Rueda-Ochoa, Oscar H Franco, Taulant Muka
Sep 20, 2018
BACKGROUND: Chagas disease (CD) is a major public health concern in Latin America and a potentially serious emerging threat in non-endemic countries. Although the association between CD and cardiac abnormalities is widely...
Elicitation of expert prior opinion
Lisa V Hampson, John Whitehead, Despina Eleftheriou, Catrin Tudur-Smith, Rachel Jones, David Jayne, Helen Hickey, Michael W Beresford, Claudia Bracaglia, Afonso Caldas, Rolando Cimaz, Joke Dehoorne, Pavla Dolezalova, Mark Friswell, Marija Jelusic, Stephen D Marks, Neil Martin, Anne-Marie McMahon, Joachim Peitz, Annet van Royen-Kerkhof, Oguz Soylemezoglu, Paul A Brogan
Nov 24, 2020
OBJECTIVES: Definitive sample sizes for clinical trials in rare diseases are usually infeasible. Bayesian methodology can be used to maximise what is learnt from clinical trials in these circumstances. We elicited expert prior...
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A Lazarus, Mona Shehata, Bruno M Simões, Alice R Greenhalgh, Sacha J Howell, Robert B Clarke, Carlos Caldas, Timotheus YF Halim, John C Marioni, Walid T Khaled
Feb 12, 2021
It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known...
Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial.
Hans de Graaf, Ruth O Payne, Iona Taylor, Kazutoyo Miura, Carol A Long, Sean C Elias, Marija Zaric, Angela M Minassian, Sarah E Silk, Lee Li, Ian D Poulton, Megan Baker, Simon J Draper, Diane Gbesemete, Nathan J Brendish, Filipa Martins, Arianna Marini, David Mekhaiel, Nick J Edwards, Rachel Roberts, Johan Vekemans, Sarah Moyle, Saul N Faust, Eleanor Berrie, Alison M Lawrie, Fergal Hill, Adrian VS Hill, Sumi Biswas
Sep 20, 2021
BACKGROUND: Transmission blocking vaccines targeting the sexual-stages of the malaria parasite could play a major role to achieve elimination and eradication of malaria. The Plasmodium falciparum Pfs25 protein (Pfs25) is the...
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