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NK cell allorecognition.
Ashley Moffett
Jul 19, 2019
My interest in uterine natural killer (NK) cells began in the early 1990s, when I and others described the striking accumulation of NK cells in the uterine mucosa during the establishment of the placenta. Whilst working as a...
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
During the innate response to many inflammatory and infectious stimuli, dendritic cells (DCs) undergo a differentiation process termed maturation. Mature DCs activate antigen-specific naive T cells. Here we show that both...
antigen expression dendritic cell cytokine release interleukin 2 Immunoregulation Signal Transduction
Published by: Rockefeller University
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
R Tallerico, CM Cristiani, E Staaf, C Garofalo, R Sottile, M Capone, Y Pico de Coaña, G Madonna, E Palella, M Wolodarski, V Carannante, D Mallardo, E Simeone, AM Grimaldi, S Johansson, P Frumento, E Gulletta, A Anichini, F Colucci, G Ciliberto, R Kiessling, K Kärre, PA Ascierto, E Carbone
Jul 20, 2017
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and...
Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.
INTRODUCTION: T cell and NK cell cytotoxicity can be mediated via the perforin/granzyme system and Fas Ligand (FasL, CD178). FasL is synthesized as a type II transmembrane protein that binds its cognate receptor Fas (CD95)....
Intensive exercise does not preferentially mobilise skin-homing T cells and NK cells
Purpose: This study investigated whether natural killer (NK) cells and CD8+ T cells expressing cutaneous lymphocyte antigen (CLA) – a homing molecule for endothelial cell leukocyte adhesion molecule 1 (ELAM-1), which enables...
Intensive exercise does not preferentially mobilise skin-homing T cells and NK cells
Purpose: This study investigated whether natural killer (NK) cells and CD8+ T cells expressing cutaneous lymphocyte antigen (CLA) – a homing molecule for endothelial cell leukocyte adhesion molecule 1 (ELAM-1), which enables...
NBEAL2 is required for neutrophil and NK cell function and pathogen defense.
John M Sowerby, David C Thomas, Simon Clare, Marion Espéli, Jose A Guerrero, Kim Hoenderdos, Katherine Harcourt, Morgan Marsden, Juneid Abdul-Karim, Mathew Clement, Robin Antrobus, Yagnesh Umrania, Philippa R Barton, Shaun M Flint, Jatinder K Juss, Alison M Condliffe, Paul A Lyons, Ian R Humphreys, Edwin R Chilvers, Willem H Ouwehand, Gordon Dougan, Kenneth GC Smith
Aug 09, 2017
Mutations in the human NBEAL2 gene cause gray platelet syndrome (GPS), a bleeding diathesis characterized by a lack of α granules in platelets. The functions of the NBEAL2 protein have not been explored outside platelet biology...
Genetic Depletion or Hyperresponsiveness of Natural Killer Cells Do Not Affect Atherosclerosis Development.
Wared Nour-Eldine, Jérémie Joffre, Kazem Zibara, Bruno Esposito, Andréas Giraud, Lynda Zeboudj, José Vilar, Megumi Terada, Patrick Bruneval, Eric Vivier, Hafid Ait-Oufella, Ziad Mallat, Sophie Ugolini, Alain Tedgui
Jun 21, 2018
RATIONALE: Chronic inflammation is central in the development of atherosclerosis. Both innate and adaptive immunities are involved. Although several studies have evaluated the functions of natural killer (NK) cells in...
Spontaneous pulmonary hypertension in genetic mouse models of natural killer cell deficiency.
Matthew T Rätsep, Stephen D Moore, Salema Jafri, Melissa Mitchell, Hugh JM Brady, Ofer Mandelboim, Mark Southwood, Nicholas W Morrell, Francesco Colucci, Mark L Ormiston
Nov 21, 2018
Natural killer (NK) cells are cytotoxic innate lymphoid cells with an established role in the regulation of vascular structure in pregnancy and cancer. Impaired NK cell function has been identified in patients with pulmonary...
Th17 angiopoietin-2 Interleukin-23 natural killer cells pulmonary hypertension Animals Basic-Leucine Zipper Transcription Factors Disease Models Animal Endothelial Cells Humans Hypertension Pulmonary Killer Cells Natural Lung Mice Natural Cytotoxicity Triggering Receptor 1 Pulmonary Artery Vascular Remodeling
A novel antibody combination to identify KIR2DS2high natural killer cells in KIR2DL3/L2/S2 heterozygous donors.
Matthew D Blunt, Pauline Rettman, Leidy Y Bastidas-Legarda, Rebecca Fulton, Valentina Capizzuto, Mohammed M Naiyer, James A Traherne, Salim I Khakoo
Dec 10, 2018
The killer cell immunoglobulin-like receptor (KIR) KIR2DS2 induces natural killer (NK) cell activation upon ligation and in genetic studies is associated with protection against certain cancers and viral infections. One of the...
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.
Oisín Huhn, Martin A Ivarsson, Lucy Gardner, Mike Hollinshead, Jane C Stinchcombe, Puran Chen, Norman Shreeve, Olympe Chazara, Lydia E Farrell, Jakob Theorell, Hormas Ghadially, Peter Parham, Gillian Griffiths, Amir Horowitz, Ashley Moffett, Andrew M Sharkey, Francesco Colucci
Feb 21, 2020
During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass cytometry, we characterise five main dILC subsets...
Published by: Nature Communications
Two-step Procedure Based on the Least Squares and Instrumental Variable Methods for Simultaneous Estimation of von Bertalanffy Growth Parameters
Advanced in the present article is a Two-step procedure designed on the methods of the least squares (LS) and instrumental variable (IV) techniques for simultaneous estimation of the three unknown parameters L∞, K and t0, which...
Published by: IGI Global Scientific Publishing
The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
Eleonora Market
Jan 01, 0001
Activation-induced cytidine deaminase (AID) is indispensable for somatic hypermutation (SHM) and class switch recombination (CSR) in B cells. SHM alters the affinity of an antibody for its corresponding antigen by introducing...
Published by: Rockefeller University
Of Mice and Men: Studying Innate and Adaptive Immunity Against the Epstein-Barr Virus
Till Strowig
Jan 01, 0001
The Epstein-Barr virus (EBV) is a lymphotropic ?-herpes virus infecting over 90% of the human adult population. A striking feature that the virus shares with other ?-herpes viruses is its oncogenic potential. This transforming...
Published by: Rockefeller University
Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion.
Hana Elasifer, Eddie CY Wang, Virginie Prod'homme, James Davies, Simone Forbes, Richard J Stanton, Mihil Patel, Ceri A Fielding, Dawn Roberts, James A Traherne, Nicole Gruber, Joachim J Bugert, Rebecca J Aicheler, Gavin WG Wilkinson
Jun 17, 2020
Molluscum contagiosum virus (MCV) is a common cause of benign skin lesions in young children and currently the only endemic human poxvirus. Following the infection of primary keratinocytes in the epidermis, MCV induces the...
MHC-I Molluscum contagiosum NK cell T cell Antigen Presentation CD8-Positive T-Lymphocytes Cell Line Down-Regulation Endoplasmic Reticulum Histocompatibility Antigens Class I Host-Pathogen Interactions Humans Immune Evasion Keratinocytes Killer Cells Natural molluscum contagiosum virus T-Lymphocytes Cytotoxic Viral Proteins
Maternal natural killer cells at the intersection between reproduction and mucosal immunity
Abstract: Many maternal immune cells populate the decidua, which is the mucosal lining of the uterus transformed during pregnancy. Here, abundant natural killer (NK) cells and macrophages help the uterine vasculature adapt to...
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy
Oisín Huhn, Martin A. Ivarsson, Lucy Gardner, Mike Hollinshead, Jane C Stinchcombe, Puran Chen, Norman Shreeve, Olympe Chazara, Lydia E. Farrell, Jakob Theorell, Hormas Ghadially, Peter Parham, Gillian Griffiths, Amir Horowitz, Ashley Moffett, Andrew M. Sharkey, Francesco Colucci
Jan 19, 2021
Abstract: During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass cytometry, we characterise five main dILC...
Local immune recognition of trophoblast in early human pregnancy
The role of the maternal immune system in reproductive success in humans remains controversial. Here we focus on the events that occur in the maternal decidua during the first few weeks of human pregnancy, because this is the...
SSIPTools
Mark D Driver, Mark J Williamson, Nicola De Mitri, Teodor Nikolov, Christopher A Hunter
Jan 06, 2022
Beyond Maternal Tolerance
Delphine M Depierreux, Jens Kieckbusch, Norman Shreeve, Delia A Hawkes, Bryan Marsh, Robert Blelloch, Andrew Sharkey, Francesco Colucci
May 24, 2022
Reproductive immunology has moved on from the classical Medawar question of 60 years ago "why doesn't the mother reject the fetus?". Looking beyond fetal-maternal tolerance, modern reproductive immunology focuses on how the...
Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture.
N Conte, I Varela, C Grove, N Manes, K Yusa, T Moreno, A Segonds-Pichon, A Bench, E Gudgin, B Herman, N Bolli, P Ellis, D Haddad, P Costeas, R Rad, M Scott, B Huntly, A Bradley, GS Vassiliou
Oct 14, 2020
Advances in sequencing technologies are giving unprecedented insights into the spectrum of somatic mutations underlying acute myeloid leukaemia with a normal karyotype (AML-NK). It is clear that the prognosis of individual...
Scale-out production of extracellular vesicles derived from natural killer cells via mechanical stimulation in a seesaw-motion bioreactor for cancer therapy.
Jianguo Wu, Di Wu, Guohua Wu, Ho-Pan Bei, Zihan Li, Han Xu, Yimin Wang, Dan Wu, Hui Liu, Shengyu Shi, Chao Zhao, Yibing Xu, Yong He, Jun Li, Changyong Wang, Xin ZHAO, ShuQi Wang
Aug 05, 2022
Extracellular vesicles (EVs) derived from immune cells have shown great anti-cancer therapeutic potential. However, inefficiency in EV generation has considerably impeded the development of EV-based basic research and clinical...
KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.
Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A Guethlein, Wesley M Marin, Sudan Tao, Lorenzo Moretta, Jill A Hollenbach, John Trowsdale, James A Traherne, Abbas Ghaderi, Peter Parham, Paul J Norman
May 18, 2020
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands....
Published by: Frontiers in immunology
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