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Results: 989
Development and testing of an intervention to increase staff knowledge and confidence in responding to health anxiety in the context of cognitive decline
Background: Memory complaint in the absence of organic pathology is a common phenomenon accounting for up to one third of patients presenting to memory clinics. Health anxiety has been specifically linked to dementia worry and...
ERT as Mobile Learning by Necessity
The term as below Emergency Remote Teaching (ERT) has been adopted worldwide. In practice, approaches to ERT have been contextual with diverse lecturer and student experiences owing to complex assemblages of sociomaterial...
Published by: IGI Global Scientific Publishing
Considerations for Setting Up Play Therapy Training Clinics
When setting up a play therapy training clinic, there are many considerations to explore regarding designing a therapeutic space, selecting toys and other materials, exploring the rationale for the toy selection and examining...
Published by: IGI Global Scientific Publishing
Small Molecule Inhibition of UBE2T/FANCL-mediated Ubiquitylation in the Fanconi Anemia Pathway
Matthew J Cornwell, Graeme J Thomson, Julia Coates, Rimma Belotserkovskaya, Ian D Waddell, Stephen P Jackson, Yaron Galanty
Sep 18, 2019
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.
Maria Secrier, Xiaodun Li, Nadeera De Silva, Matthew D Eldridge, Gianmarco Contino, Jan Bornschein, Shona MacRae, Nicola Grehan, Maria O'Donovan, Ahmad Miremadi, Tsun-Po Yang, Lawrence Bower, Hamza Chettouh, Jason Crawte, Núria Galeano-Dalmau, Anna Grabowska, John Saunders, Tim Underwood, Nicola Waddell, Andrew P Barbour, Barbara Nutzinger, Achilleas Achilleos, Paul AW Edwards, Andy G Lynch, Simon Tavaré, Rebecca C Fitzgerald, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium
Jul 28, 2016
Development and testing of an intervention to increase staff knowledge and confidence in responding to health anxiety in the context of cognitive decline
Background: Memory complaint in the absence of organic pathology is a common phenomenon accounting for up to one third of patients presenting to memory clinics. Health anxiety has been specifically linked to dementia worry and...
Chromatin interactome mapping at 139 independent breast cancer risk signals.
Jonathan Beesley, Haran Sivakumaran, Mahdi Moradi Marjaneh, Luize G Lima, Kristine M Hillman, Susanne Kaufmann, Natasha Tuano, Nehal Hussein, Sunyoung Ham, Pamela Mukhopadhyay, Stephen Kazakoff, Jason S Lee, Kyriaki Michailidou, Daniel R Barnes, Antonis C Antoniou, Laura Fachal, Alison M Dunning, Douglas F Easton, Nicola Waddell, Joseph Rosenbluh, Andreas Möller, Georgia Chenevix-Trench, Juliet D French, Stacey L Edwards
Feb 08, 2020
BACKGROUND:Genome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these signals frequently fall in distal regulatory DNA elements...
Published by: Genome biology
Chromatin interactome mapping at 139 independent breast cancer risk signals.
Jonathan Beesley, Haran Sivakumaran, Mahdi Moradi Marjaneh, Luize G Lima, Kristine M Hillman, Susanne Kaufmann, Natasha Tuano, Nehal Hussein, Sunyoung Ham, Pamela Mukhopadhyay, Stephen Kazakoff, Jason S Lee, Kyriaki Michailidou, Daniel R Barnes, Antonis C Antoniou, Laura Fachal, Alison M Dunning, Douglas F Easton, Nicola Waddell, Joseph Rosenbluh, Andreas Möller, Georgia Chenevix-Trench, Juliet D French, Stacey L Edwards
Aug 06, 2019
Mitochondrial mutations and metabolic adaptation in pancreatic cancer.
Rae-Anne Hardie, Ellen van Dam, Mark Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F Shearer, Jessie McKenna, David Miller, Nicola Waddell, John V Pearson, Sean M Grimmond, Australian Pancreatic Cancer Genome Initiative, Leonid Sazanov, Andrew V Biankin, Silas Villas-Boas, Andrew J Hoy, Nigel Turner, Darren N Saunders
Jan 31, 2017
BACKGROUND: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic strategy...
Chromatin interactome mapping at 139 independent breast cancer risk signals
Jonathan Beesley, Haran Sivakumaran, Mahdi Moradi Marjaneh, Luize G. Lima, Kristine M. Hillman, Susanne Kaufmann, Natasha Tuano, Nehal Hussein, Sunyoung Ham, Pamela Mukhopadhyay, Stephen Kazakoff, Jason S. Lee, Kyriaki Michailidou, Daniel R. Barnes, Antonis C. Antoniou, Laura Fachal, Alison M. Dunning, Douglas F. Easton, Nicola Waddell, Joseph Rosenbluh, Andreas Möller, Georgia Chenevix-Trench, Juliet D. French, Stacey L. Edwards
Jun 06, 2020
Non-coding RNAs underlie genetic predisposition to breast cancer
Mahdi Moradi Marjaneh, Jonathan Beesley, Tracy A. O’Mara, Pamela Mukhopadhyay, Lambros T. Koufariotis, Stephen Kazakoff, Nehal Hussein, Laura Fachal, Nenad Bartonicek, Kristine M. Hillman, Susanne Kaufmann, Haran Sivakumaran, Chanel E. Smart, Amy E. McCart Reed, Kaltin Ferguson, Jodi M. Saunus, Sunil R. Lakhani, Daniel R. Barnes, Antonis C. Antoniou, Marcel E. Dinger, Nicola Waddell, Douglas F. Easton, Alison M. Dunning, Georgia Chenevix-Trench, Stacey L. Edwards, Juliet D. French
Jun 06, 2020
A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding.
Jodie N Painter, Susanne Kaufmann, Tracy A O'Mara, Kristine M Hillman, Haran Sivakumaran, Hatef Darabi, Timothy Ht Cheng, John Pearson, Stephen Kazakoff, Nicola Waddell, Erling A Hoivik, Ellen L Goode, Rodney J Scott, Ian Tomlinson, Alison M Dunning, Douglas F Easton, Juliet D French, Helga B Salvesen, Pamela M Pollock, Deborah J Thompson, Amanda B Spurdle, Stacey L Edwards
May 17, 2016
Chromosomes Human Pair 14 Endometrial Neoplasms Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Phosphatidylinositol 3-Kinases Polymorphism Single Nucleotide Protein Binding Proto-Oncogene Proteins c-akt Risk Factors Signal Transduction Uterine Neoplasms YY1 Transcription Factor
Chromatin interactome mapping at 139 independent breast cancer risk signals
Jonathan Beesley, Haran Sivakumaran, Mahdi Moradi Marjaneh, Luize G. Lima, Kristine M. Hillman, Susanne Kaufmann, Natasha Tuano, Nehal Hussein, Sunyoung Ham, Pamela Mukhopadhyay, Stephen Kazakoff, Jason S. Lee, Kyriaki Michailidou, Daniel R. Barnes, Antonis C. Antoniou, Laura Fachal, Alison M. Dunning, Douglas F. Easton, Nicola Waddell, Joseph Rosenbluh, Andreas Möller, Georgia Chenevix-Trench, Juliet D. French, Stacey L. Edwards
Jan 06, 2021
EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers.
Elizabeth C Smyth, Georgios Vlachogiannis, Somaieh Hedayat, Alice Harbery, Sanna Hulkki-Wilson, Massimiliano Salati, Kyriakos Kouvelakis, Javier Fernandez-Mateos, George D Cresswell, Elisa Fontana, Therese Seidlitz, Clare Peckitt, Jens C Hahne, Andrea Lampis, Ruwaida Begum, David Watkins, Sheela Rao, Naureen Starling, Tom Waddell, Alicia Okines, Tom Crosby, Was Mansoor, Jonathan Wadsley, Gary Middleton, Matteo Fassan, Andrew Wotherspoon, Chiara Braconi, Ian Chau, Igor Vivanco, Andrea Sottoriva, Daniel E Stange, David Cunningham, Nicola Valeri
Nov 11, 2020
Gastric adenocarcinoma gastrointestinal cancer molecular oncology OESOPHAGEAL CANCER Adenocarcinoma Aged Antibiotics Antineoplastic Antineoplastic Agents Immunological Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Epirubicin ErbB Receptors Esophageal Neoplasms Humans Male Middle Aged Panitumumab Stomach Neoplasms
A Semantic Framework Supporting Multilayer Networks Analysis for Rare Diseases
Understanding the role played by genetic variations in diseases, exploring genomic variants and discovering disease-associated loci are among the most pressing challenges of genomic medicine. A huge and ever-increasing amount of...
Published by: IGI Global Scientific Publishing
Non-coding RNAs underlie genetic predisposition to breast cancer
Mahdi Moradi Marjaneh, Jonathan Beesley, Tracy A. O’Mara, Pamela Mukhopadhyay, Lambros T. Koufariotis, Stephen Kazakoff, Nehal Hussein, Laura Fachal, Nenad Bartonicek, Kristine M. Hillman, Susanne Kaufmann, Haran Sivakumaran, Chanel E. Smart, Amy E. McCart Reed, Kaltin Ferguson, Jodi M. Saunus, Sunil R. Lakhani, Daniel R. Barnes, Antonis C. Antoniou, Marcel E. Dinger, Nicola Waddell, Douglas F. Easton, Alison M. Dunning, Georgia Chenevix-Trench, Stacey L. Edwards, Juliet D. French
Jan 06, 2021
Non-coding RNAs underlie genetic predisposition to breast cancer.
Mahdi Moradi Marjaneh, Jonathan Beesley, Tracy A O'Mara, Pamela Mukhopadhyay, Lambros T Koufariotis, Stephen Kazakoff, Nehal Hussein, Laura Fachal, Nenad Bartonicek, Kristine M Hillman, Susanne Kaufmann, Haran Sivakumaran, Chanel E Smart, Amy E McCart Reed, Kaltin Ferguson, Jodi M Saunus, Sunil R Lakhani, Daniel R Barnes, Antonis C Antoniou, Marcel E Dinger, Nicola Waddell, Douglas F Easton, Alison M Dunning, Georgia Chenevix-Trench, Stacey L Edwards, Juliet D French
Dec 16, 2019
BACKGROUND: Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements such as enhancers and promoters. However, the...
Participation in Software Development
Francis Harvey, Aura Moldovan, Eric Losang, Tim Leibert, Maria Turchenko, Nicola Simon, Rowenia Bender
Jan 01, 2022
Participatory planning holds important lessons for improving local government capabilities and responsiveness, but overall procedural regulations and statutory frameworks make its relevance for participatory IT development often...
Published by: IGI Global Scientific Publishing
Non-coding RNAs underlie genetic predisposition to breast cancer.
Mahdi Moradi Marjaneh, Jonathan Beesley, Tracy A O'Mara, Pamela Mukhopadhyay, Lambros T Koufariotis, Stephen Kazakoff, Nehal Hussein, Laura Fachal, Nenad Bartonicek, Kristine M Hillman, Susanne Kaufmann, Haran Sivakumaran, Chanel E Smart, Amy E McCart Reed, Kaltin Ferguson, Jodi M Saunus, Sunil R Lakhani, Daniel R Barnes, Antonis C Antoniou, Marcel E Dinger, Nicola Waddell, Douglas F Easton, Alison M Dunning, Georgia Chenevix-Trench, Stacey L Edwards, Juliet D French
Feb 08, 2020
BACKGROUND:Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements such as enhancers and promoters. However, the...
Published by: Genome biology
Integrating CBT and CFT within a case formulation approach to reduce depression and anxiety in an older adult with a complex mental and physical health history
Nicola Birdsey
Oct 12, 2020
Depression and anxiety are major contributors to growing healthcare costs in the UK, particularly with an increasingly ageing population. However, identification of mental health needs in older adults has been overshadowed by a...
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