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Results: 255
In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.
Simon J Bulley, Alaa Droubi, Jonathan H Clarke, Karen E Anderson, Len R Stephens, Phillip T Hawkins, Robin F Irvine
Aug 22, 2016
Akt mTOR phosphatidylinositol (4 5)-bisphosphate Phosphatidylinositol 5-phosphate phosphatidylinositol 5-phosphate 4-kinase Animals B-Lymphocytes Cell Line Chickens Humans Mechanistic Target of Rapamycin Complex 2 Phosphatidylinositol Phosphates Phosphorylation Phosphotransferases Phosphotransferases (Alcohol Group Acceptor) Proto-Oncogene Proteins c-akt Signal Transduction TOR Serine-Threonine Kinases
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 + T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Mar 22, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T Hawkins, Len R Stephens, Simon T Barry, Klaus Okkenhaug
Feb 03, 2021
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit...
CD4-Positive T-Lymphocytes Animals Mice Inbred C57BL Mice Multiprotein Complexes Receptors Antigen T-Cell Interleukin-2 Lymphocyte Activation Specific Pathogen-Free Organisms Signal Transduction Cell Differentiation Gene Knockout Techniques Class I Phosphatidylinositol 3-Kinases CRISPR-Cas Systems Gene Editing
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
David Gyori, Ee Lyn Lim, Francis M Grant, Dominik Spensberger, Rahul Roychoudhuri, Stephen J Shuttleworth, Klaus Okkenhaug, Len R Stephens, Phillip T Hawkins
Aug 20, 2018
cancer immunotherapy immunology MACROPHAGES oncology T cells Aminopyridines Animals Cell Line Tumor Class I Phosphatidylinositol 3-Kinases Diphtheria Toxin Disease Models Animal Drug Resistance Neoplasm Female Forkhead Transcription Factors Gene Knockout Techniques Humans Lymphocyte Depletion MACROPHAGES Male Mice Mice Transgenic Neoplasms Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Primary Cell Culture Purines Pyrroles Quinazolinones Receptors Granulocyte-Macrophage Colony-Stimulating Factor T-Lymphocytes Regulatory Tumor Microenvironment
Developing a Perspective on Schools as Complex, Evolving, Loosely Linking Systems
The rationale for this article is to give complexity the central place it warrants in school leadership, management and organisational practice and research. We analyse the relevant literature, particularly that relating to...
Characterization of De Novo Di-Iron Metalloproteins
Stephanie Hawkins
Jan 01, 0001
The unique structure-function relationship of proteins has made de novo metalloprotein models a valuable tool in obtaining a deeper understanding of these essential biological molecules. To study the impact of active site...
Published by: Ursinus College
Reducing the carbon emissions of building construction using thin-shell concrete floors
Will Hawkins
Jun 01, 2022
Steel and concrete are consumed in vast quantities as the global population continues to grow, develop and urbanise. Both these materials are carbon-intensive to produce, and construction therefore represents one of the hardest...
Reducing the carbon emissions of building construction using thin-shell concrete floors
Will Hawkins
Jun 01, 2022
Steel and concrete are consumed in vast quantities as the global population continues to grow, develop and urbanise. Both these materials are carbon-intensive to produce, and construction therefore represents one of the hardest...
Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.
Hashem Koohy, Daniel J Bolland, Louise S Matheson, Stefan Schoenfelder, Claudia Stellato, Andrew Dimond, Csilla Várnai, Peter Chovanec, Tamara Chessa, Jeremy Denizot, Raquel Manzano Garcia, Steven W Wingett, Paula Freire-Pritchett, Takashi Nagano, Phillip Hawkins, Len Stephens, Sarah Elderkin, Mikhail Spivakov, Peter Fraser, Anne E Corcoran, Patrick D Varga-Weisz
Jun 24, 2019
BACKGROUND: Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression...
On the pathwise approximation of stochastic differential equations
We consider one-step methods for integrating stochastic differential equations and prove pathwise convergence using ideas from rough path theory. In contrast to alternative theories of pathwise convergence, no knowledge is...
Framing the policy debate over spirits excise tax in Poland
Industry lobbying remains an obstacle to effective health-oriented alcohol policy. In 2013, an increase in excise tax on spirits was announced by the Polish government. This article presents a qualitative analysis of the...
An analytical failure envelope for the design of textile reinforced concrete shells
Shells have the potential to considerably reduce material consumption in buildings due to their high structural efficiency compared to equivalent structures acting in bending. Textile reinforced concrete (TRC) is a promising...
Framing the policy debate over spirits excise tax in Poland
Industry lobbying remains an obstacle to effective health-oriented alcohol policy. In 2013, an increase in excise tax on spirits was announced by the Polish government. This article presents a qualitative analysis of the...
Predictors of Juvenile Court Dispositions in a First-Time Offender Population
Scholars and policy makers have long been troubled by the potential for some youth to receive disparate sanctioning as a function of extralegal factors, especially against the backdrop of ethnic/racial minority group...
juvenile justice graduated sanctions predictors of dispositional outcomes racial/ ethnic minorities Criminology Psychology
Published by: Digital Commons @ Texas A&M University-San Antonio
Ethical Issues in Conducting Forensic Evaluations
The role of the forensic mental health professional (MHP) often differs substantially from that of the typical clinician. These differences bear directly on the ethical delivery of services.
Published by: Digital Commons @ Texas A&M University-San Antonio
Holistic regenerative design
Synopsis
In the August 2023 issue of The Structural Engineer, Oliver Broadbent and James Norman presented the principles of regenerative design, and Will Arnold and Phil Isaac discussed how structural engineers can achieve...
In the August 2023 issue of The Structural Engineer, Oliver Broadbent and James Norman presented the principles of regenerative design, and Will Arnold and Phil Isaac discussed how structural engineers can achieve...
Regenerative design construction sustainability /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/life_on_land name=SDG 15 - Life on Land
A Combined Theory of Change-Group Model Building Approach to Evaluating “Farm to Fork” Models for School Feeding in the Caribbean
There is a scarcity of research on building nutrition-sensitive value chains (NSVCs) to improve diets and nutrition outcomes of populations in the Caribbean. This study contributes to filling this research gap by...
Holistic regenerative design
Synopsis
In the August 2023 issue of The Structural Engineer, Oliver Broadbent and James Norman presented the principles of regenerative design, and Will Arnold and Phil Isaac discussed how structural engineers can achieve...
In the August 2023 issue of The Structural Engineer, Oliver Broadbent and James Norman presented the principles of regenerative design, and Will Arnold and Phil Isaac discussed how structural engineers can achieve...
Regenerative design construction sustainability /dk/atira/pure/sustainabledevelopmentgoals/industry_innovation_and_infrastructure name=SDG 9 - Industry, Innovation, and Infrastructure /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action /dk/atira/pure/sustainabledevelopmentgoals/responsible_consumption_and_production name=SDG 12 - Responsible Consumption and Production /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities /dk/atira/pure/sustainabledevelopmentgoals/life_on_land name=SDG 15 - Life on Land
Influence of Turn-Taking in Musical and Spoken Activities on Empathy and Self-Esteem of Socially Vulnerable Young Teenagers.
This study describes a preliminary test of the hypothesis that, when people engage in musical and linguistic activities designed to enhance the interactive, turn-taking properties of typical conversation, they benefit in ways...
Developing a Perspective on Schools as Complex, Evolving, Loosely Linking Systems
The rationale for this article is to give complexity the central place it warrants in school leadership, management and organisational practice and research. We analyse the relevant literature, particularly that relating to...
Metadata for Harvesting
The OAI Protocol for Metadata Harvesting offers the prospect of resource discovery tools far beyond what is currently available to users of the Web via standard search engines. This article illustrates how existing information...
Fractures in the education-economy relationship
This paper undertakes a critical theoretical and empirical analysis of the traditional approach to analysing the education-economy relationship: skill bias technological change theory. It argues that while leading skill bias...
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