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Lysozyme Fibrils Alter the Mechanism of Insulin Amyloid Aggregation
Protein aggregation into amyloid fibrils is linked to multiple disorders. The understanding of how natively non-harmful proteins convert to these highly cytotoxic amyloid aggregates is still not sufficient, with new ideas and...
Lysozyme Fibrils Alter the Mechanism of Insulin Amyloid Aggregation.
Protein aggregation into amyloid fibrils is linked to multiple disorders. The understanding of how natively non-harmful proteins convert to these highly cytotoxic amyloid aggregates is still not sufficient, with new ideas and...
Prism adaptation does not alter configural processing of faces
Patients with hemispatial neglect ('neglect') following a brain lesion show difficulty responding or orienting to objects and events on the left side of space. Substantial evidence supports the use of a sensorimotor training...
Impulsivity in Gambling Disorder and problem gambling
Gambling Disorder is a prevalent psychiatric condition often linked to dysfunction of cognitive domains regulating impulsive behavior. Despite the centrality of impulsivity to neurobiological models of Gambling Disorder, a...
It Takes a Community to Educate a Child
This study was part of a larger research project examining education success across the Inuit regions of Canada. This case study highlights the insights of students, educators, and parents in considering the factors contributing...
Published by: The Morning Watch: Educational and Social Analysis
Prism adaptation does not alter configural processing of faces
Patients with hemispatial neglect ('neglect') following a brain lesion show difficulty responding or orienting to objects and events on the left side of space. Substantial evidence supports the use of a sensorimotor training...
It Takes a Community to Educate a Child
This study was part of a larger research project examining education success across the Inuit regions of Canada. This case study highlights the insights of students, educators, and parents in considering the factors contributing...
Published by: The Morning Watch: Educational and Social Analysis
The evolution of adult pollen feeding did not alter postembryonic growth in Heliconius butterflies.
Laura Hebberecht, Lina Melo-Flórez, Fletcher J Young, W Owen McMillan, Stephen H Montgomery
Jun 29, 2022
For many animals, the availability and provision of dietary resources can vary markedly between juvenile and adult stages, often leading to a temporal separation of nutrient acquisition and use. Juvenile developmental programs...
An ant colony algorithm for the multi-compartment vehicle routing problem
We demonstrate the use of Ant Colony System (ACS) to solve the capacitated
vehicle routing problem associated with collection of recycling waste from
households, treated as nodes in a spatial network. For networks where...
vehicle routing problem associated with collection of recycling waste from
households, treated as nodes in a spatial network. For networks where...
Which Democratic Way to Go?
There are concerns amongst researchers and the general public that social media platforms threaten democratic values. Social media corporations and their engineers have responded to these concerns with various design solutions....
Published by: IGI Global Scientific Publishing
Using the internet to cope with chronic fatigue syndrome/myalgic encephalomyelitis in adolescence
Background: Adolescents are increasingly using online resources for health purposes. Previous studies suggest that online provision of information about chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is...
An ant colony algorithm for the multi-compartment vehicle routing problem
We demonstrate the use of Ant Colony System (ACS) to solve the capacitated
vehicle routing problem associated with collection of recycling waste from
households, treated as nodes in a spatial network. For networks where...
vehicle routing problem associated with collection of recycling waste from
households, treated as nodes in a spatial network. For networks where...
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.
International Typhoid Consortium, Vanessa K Wong, Kathryn E Holt, Chinyere Okoro, Stephen Baker, Derek J Pickard, Florian Marks, Andrew J Page, Grace Olanipekun, Huda Munir, Roxanne Alter, Paul D Fey, Nicholas A Feasey, Francois-Xavier Weill, Simon Le Hello, Peter J Hart, Samuel Kariuki, Robert F Breiman, Melita A Gordon, Robert S Heyderman, Jan Jacobs, Octavie Lunguya, Chisomo Msefula, Calman A MacLennan, Karen H Keddy, Anthony M Smith, Robert S Onsare, Elizabeth de Pinna, Satheesh Nair, Ben Amos, Gordon Dougan, Stephen Obaro
Feb 19, 2019
BACKGROUND: The burden of typhoid in sub-Saharan African (SSA) countries has been difficult to estimate, in part, due to suboptimal laboratory diagnostics. However, surveillance blood cultures at two sites in Nigeria have...
Neuronal Reprogramming for Tissue Repair and Neuroregeneration
Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural reprogramming methods have been established, using pluripotent stem cells (PSCs) or direct...
Trans-diagnostic measurement of impulsivity and compulsivity
Roxanne W Hook, Jon E Grant, Konstantinos Ioannidis, Jeggan Tiego, Murat Yücel, Paul Wilkinson, Samuel R Chamberlain
Oct 26, 2020
INTRODUCTION: Impulsivity and compulsivity are important constructs, relevant to understanding behaviour in the general population, as well as in particular mental disorders (e.g. attention deficit hyperactivity disorder...
Using the internet to cope with chronic fatigue syndrome/myalgic encephalomyelitis in adolescence
Background: Adolescents are increasingly using online resources for health purposes. Previous studies suggest that online provision of information about chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is...
Cognitive deficits in problematic internet use
Konstantinos Ioannidis, Roxanne Hook, Anna E Goudriaan, Simon Vlies, Naomi A Fineberg, Jon E Grant, Samuel R Chamberlain
Feb 05, 2019
BACKGROUND: Excessive use of the internet is increasingly recognised as a global public health concern. Individual studies have reported cognitive impairment in problematic internet use (PIU), but have suffered from various...
A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.
Cora Olpe, Doran Khamis, Maria Chukanova, Nefeli Skoufou-Papoutsaki, Richard Kemp, Kate Marks, Cerys Tatton, Cecilia Lindskog, Anna Nicholson, Roxanne Brunton-Sim, Shalini Malhotra, Rogier Ten Hoopen, Rachael Stanley, Douglas J Winton, Edward Morrissey
Apr 16, 2021
BACKGROUND & AIMS: Colorectal cancer (CRC) is thought to arise when the cumulative mutational burden within colonic crypts exceeds a certain threshold that leads to clonal expansion and ultimately neoplastic transformation....
Colorectal Cancer Initiation crypt fission crypt fusion Intestinal Crypt Adolescent Adult Age Factors Aged Aged 80 and over Cell Proliferation Cell Transformation Neoplastic Colonic Polyps Colorectal Neoplasms Diffusion Epithelial Cells Female Histone Demethylases Humans Intestinal Mucosa Male Middle Aged Models Biological Mutation Neoplastic Stem Cells Proto-Oncogene Proteins p21(ras) Young Adult
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma
Devora Najjar, Josh Rainbow, Sanjay Timilsina, Pawan Jolly, Helena De Puig, Mohamed Yafia, Nolan Durr, Galit Alter, Jonathan Li, Xu Yu, David Walt, Joseph Paradiso, Pedro Estrela, James Collins, Donald E. Ingber
Aug 31, 2022
Rapid, accurate and frequent detection of the RNA of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and of serological host antibodies to the virus would facilitate the determination of the immune status of...
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma
Devora Najjar, Josh Rainbow, Sanjay Timilsina, Pawan Jolly, Helena De Puig, Mohamed Yafia, Nolan Durr, Galit Alter, Jonathan Li, Xu Yu, David Walt, Joseph Paradiso, Pedro Estrela, James Collins, Donald E. Ingber
Aug 31, 2022
Rapid, accurate and frequent detection of the RNA of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and of serological host antibodies to the virus would facilitate the determination of the immune status of...
Neuronal Reprogramming for Tissue Repair and Neuroregeneration.
Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural reprogramming methods have been established, using pluripotent stem cells (PSCs) or direct...
Histone modifiers are oxygen sensors.
Hypoxia signals directly to chromatin via histone demethylases to alter gene expression
Improving outcomes in adults with epilepsy and intellectual disability (EpAID) using a nurse-led intervention
Howard Ring, Nakita Gilbert, Roxanne Hook, Adam Platt, Christopher Smith, Fiona Irvine, Cam Donaldson, Elizabeth Jones, Joanna Kelly, Adrian Mander, Caroline Murphy, Mark Pennington, Angela Pullen, Marcus Redley, Simon Rowe, James Wason
Jun 09, 2016
clinical trial Clinical trials unit Cluster trial Controlled trial cost-effectiveness Epilepsy Epilepsy nurse Intellectual Disability Nurse-led intervention Pragmatic Quality of life Randomised Treatment Treatment as usual Adult Clinical Protocols Data Collection Epilepsy Humans Intellectual Disability Nurses Outcome Assessment Health Care qualitative research Research Design Sample Size
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