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The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends
Matthias M. Schneider, Saurabh Gautam, Therese W. Herling, Ewa Andrzejewska, Georg Krainer, Alyssa M. Miller, Victoria A. Trinkaus, Quentin A. E. Peter, Francesco Simone Ruggeri, Michele Vendruscolo, Andreas Bracher, Christopher M. Dobson, F. Ulrich Hartl, Tuomas P. J. Knowles
Oct 18, 2021
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
Matthias M Schneider, Saurabh Gautam, Therese W Herling, Ewa Andrzejewska, Georg Krainer, Alyssa M Miller, Victoria A Trinkaus, Quentin AE Peter, Francesco Simone Ruggeri, Michele Vendruscolo, Andreas Bracher, Christopher M Dobson, F Ulrich Hartl, Tuomas PJ Knowles
Sep 01, 2021
Molecular chaperones contribute to the maintenance of cellular protein homoeostasis through assisting de novo protein folding and preventing amyloid formation. Chaperones of the Hsp70 family can further disaggregate otherwise...
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
Matthias M Schneider, Saurabh Gautam, Therese W Herling, Ewa Andrzejewska, Georg Krainer, Alyssa M Miller, Victoria A Trinkaus, Quentin A E Peter, Francesco Simone Ruggeri, Michele Vendruscolo, Andreas Bracher, Christopher M Dobson, F Ulrich Hartl, Tuomas P J Knowles
Nov 22, 2021
Molecular chaperones contribute to the maintenance of cellular protein homoeostasis through assisting de novo protein folding and preventing amyloid formation. Chaperones of the Hsp70 family can further disaggregate otherwise...
Published by: Nature Communications
The Plural Self: A Comprehensive Exploration of the Effects of Hierarchy in Jhumpa Lahiri's Interpreter of Maladies
Aastha Gautam
Jan 01, 0001
Storytelling is an act just as much personal as it is political. Stories help us to craft bridges and allow us to attempt to understand the lived experiences of those different from ourselves. More than that, they allow us to...
Jhumpa Lahiri Empathy Cultural Resistance Patriarchy masculinity Femininity colonialism Capitalism Arts and Humanities Literature in English, North America Literature in English, North America, Ethnic and Cultural Minority Philosophy
Published by: Ursinus College
Antecedents of E-Marketing of Agriculture Products in This Digital Era
Gautam Srivastava
Jun 15, 2022
Agriculture is the backbone of the Indian economy. The majority of the citizens of this country are dependent upon the agricultural supply chain for the livelihood. This study shows the role of the workforce in this digital era...
Published by: IGI Global Scientific Publishing
A scoping review of case law relating to support and treatment for people with Prader-Willi Syndrome.
BACKGROUND: Prader-Willi Syndrome (PWS) is a complex multisystem genetic disorder associated with several challenges for people with PWS themselves, and for their families and care givers. Support around access to food is a...
Fuzzy Drug Targets
Suman Saurabh, Karthik Nadendla, Shubh Sanket Purohit, Ponnurengam Malliappan Sivakumar, Sibel Cetinel
Apr 17, 2023
Intrinsically disordered proteins (IDPs) and regions (IDRs) form a large part of the eukaryotic proteome. Contrary to the structure-function paradigm, the disordered proteins perform a myriad of functions in vivo. Consequently...
Auto-generating databases of Yield Strength and Grain Size using ChemDataExtractor.
The emerging field of material-based data science requires information-rich databases to generate useful results which are currently sparse in the stress engineering domain. To this end, this study uses the'materials-aware'...
Association of thirty-year alcohol consumption typologies and fatty liver
Youth and Multiplayer Mobile Games Adoption
The rapidly growing technology has created new form of gaming platform for youth. The online gaming industry is revolutionised with the emergence of information technology and advanced graphical engines. The purpose of this...
Published by: IGI Global Scientific Publishing
An Unreliable Batch Arrival Retrial Queueing System With Bernoulli Vacation Schedule and Linear Repeated Attempts
This article deals with the steady-state behavior of an MX/G/1 retrial queue with the Bernoulli vacation schedule and unreliable server, under linear retrial policy. Breakdowns can occur randomly at any instant while the server...
Published by: IGI Global Scientific Publishing
Big Data and Cloud Computing
With evolving technology, a huge data is being generated from everywhere in various forms. The driving factors for the evolution of data, such as retail, media, banking, healthcare, and education, leads to a very large and...
Published by: IGI Global Scientific Publishing
Antecedents of Buying Behavior Patterns of E-Consumers
In the new digitalized era, seller and buyer interact at the market space whereby the market space is provided on a different digital platform. Gradually, consumers are transforming into e-consumers. The COVID-19 pandemic has...
Published by: IGI Global Scientific Publishing
Particle Morphology and Lithium Segregation to Surfaces of the Li<sub>7</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub> Solid Electrolyte
Pieremanuele Canepa, James A. Dawson, Gopalakrishnan Sai Gautam, Joel M. Statham, Stephen C. Parker, M. Saiful Islam
May 08, 2018
Solid electrolytes for solid-state Li-ion batteries are stimulating considerable interest for next-generation energy storage applications. The Li7La3Zr2O12 garnet-type solid...
Particle Morphology and Lithium Segregation to Surfaces of the Li<sub>7</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub> Solid Electrolyte
Pieremanuele Canepa, James A. Dawson, Gopalakrishnan Sai Gautam, Joel M. Statham, Stephen C. Parker, M. Saiful Islam
May 08, 2018
Solid electrolytes for solid-state Li-ion batteries are stimulating considerable interest for next-generation energy storage applications. The Li7La3Zr2O12 garnet-type solid...
Analysis of Heart Disease Using Parallel and Sequential Ensemble Methods With Feature Selection Techniques
This paper has organized a heart disease-related dataset from UCI repository. The organized dataset describes variables correlations with class-level target variables. This experiment has analyzed the variables by different...
Published by: IGI Global Scientific Publishing
Automated Ruleset Generation for “HTTPS Everywhere”
This paper details the implementation of a Web crawler aimed at automating ruleset construction for “HTTPS Everywhere,” with a goal to convert HTTP URLs to secure HTTPS equivalents for enhanced communication security. Developed...
Published by: IGI Global Scientific Publishing
LC3-positive structures are prominent in autophagy-deficient cells
Gautam Runwal, Eleanna Stamatakou, Farah H. Siddiqi, Claudia Puri, Ye Zhu, David C. Rubinsztein
Jul 11, 2020
Abstract: Autophagy is an evolutionarily conserved process across eukaryotes that degrades cargoes like aggregate-prone proteins, pathogens, damaged organelles and macromolecules via delivery to lysosomes. The process involves...
An Extensive Review of Web-Based Multi-Granularity Service Composition
The paper reviews the efforts to compose SOAP, non-SOAP and non-web services. Traditionally efforts were made for composite SOAP services, however, these efforts did not include the RESTful and non-web services. A SOAP service...
Published by: IGI Global Scientific Publishing
Exploring the Factors Impacting Seller Performance During Online Sales Events in the E-Commerce Marketplace in India
The Indian ecommerce industry has been growing substantially because of changing mindset of the Indian customers and ease of shopping online. A large number of sellers had registered on online marketplaces so that the sellers...
Published by: IGI Global Scientific Publishing
Learning Management System Adoption
The growing popularity of online learning has put learning management systems (LMS) at the forefront of learning technologies. The adoption of LMS by students has therefore been a major driving force for online education....
Published by: IGI Global Scientific Publishing
Empirical Parameter to Compare Molecule-Electrode Interfaces in Large-Area Molecular Junctions.
Marco Carlotti, Saurabh Soni, Andrii Kovalchuk, Sumit Kumar, Stephan Hofmann, Ryan C Chiechi
Jul 01, 2022
This paper describes a simple model for comparing the degree of electronic coupling between molecules and electrodes across different large-area molecular junctions. The resulting coupling parameter can be obtained directly from...
Improving the quantitative classification of Erlenmeyer flask deformities
Gautam Adusumilli, Joshua D. Kaggie, Simona D’Amore, Timothy M. Cox, Patrick Deegan, James W. MacKay, Scott McDonald
Jul 30, 2021
Abstract: The Erlenmeyer flask deformity is a common skeletal modeling deformity, but current classification systems are binary and may restrict its utility as a predictor of associated skeletal conditions. A quantifiable...
LC3-positive structures are prominent in autophagy-deficient cells.
Gautam Runwal, Eleanna Stamatakou, Farah H Siddiqi, Claudia Puri, Ye Zhu, David C Rubinsztein
Jul 02, 2019
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