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Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.
Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L Seifert, Marshall W Hogarth, Davi A Mazala, Kai Ting Huang, Rita Horvath, Jyoti K Jaiswal, György Hajnóczky
Apr 21, 2020
Muscle function is regulated by Ca2+, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca2+ delivery to the mitochondrial matrix...
Atrophy autosomal recessive Calcium Injury membrane Mitochondria mitochondrial disease muscle disease Adolescent Adult Animals Calcium Calcium Signaling Calcium-Binding Proteins Cation Transport Proteins Cell Membrane Cytosol Female FIBROBLASTS Homeostasis Humans Male Mice Knockout Mitochondria Mitochondrial Membrane Transport Proteins Models Biological Muscle Contraction Muscle Weakness Muscle Skeletal Muscular Atrophy Sarcolemma Tetanus Wasting Syndrome
Educational Mobile Games as a Tool for Increasing Vocabulary When Learning a Foreign Language
The study considers the features of the algorithms of educational mobile games. The research analyzes the main functions and characteristics of 55 educational mobile games. The system of each mobile application for learning a...
Published by: IGI Global Scientific Publishing
The Ursinus Weekly, November 6, 1922
F. Nelsen Schlegel
Jan 01, 0001
Albright conquers Ursinus in battle on Myerstown field Ursinus Woman's Club entertains senior girls Radio: a liberal education for the modern world Students give program at Ladies' Aid social Graham Marr and Valentina Crespi...
Ursinus College Collegeville Pennsylvania newspaper Football George Stibitz YMCA YWCA Schaff literary society Zwinglian literary society cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Port Dada Integration
The maritime supply chain is growing in complexity. Ports are at the crossroads of many activities, modes, and stakeholders, and are actively becoming digital hubs. Today, digital and physical connectivity go hand in hand. The...
Computer Science and Information Technology Artificial Intelligence Data Management Business and Management
Published by: IGI Global Scientific Publishing
Ulisse Aldrovandi’s Color Sensibility
Valentina Pugliano
Dec 08, 2015
Famed for his collection of drawings of naturalia and his thoughts on the relationship between painting and natural knowledge, it now appears that the Bolognese naturalist Ulisse Aldrovandi (1522–1605) also pondered specifically...
Mobile Applications in Education
The purpose of the study is to consider the features of the use of mobile applications for the development of professional competencies, in particular cognitive skills, and their general impact on the effectiveness of learning....
Published by: IGI Global Scientific Publishing
RaVÆn
Vít Růžička, Anna Vaughan, Daniele De Martini, James Fulton, Valentina Salvatelli, Chris Bridges, Gonzalo Mateo-Garcia, Valentina Zantedeschi
Oct 10, 2022
Applications such as disaster management enormously benefit from rapid availability of satellite observations. Traditionally, data analysis is performed on the ground after being transferred-downlinked-to a ground station....
Extrastriatal 123 I-FP-CIT SPECT impairment in Parkinson’s disease – the PPMI cohort
Abstract: Background: Neuropathological data and nuclear medicine imaging show extensive serotonergic impairment in Parkinson’s disease (PD). We undertook a case-controlled analysis of 123I-FP-CIT SPECT images to measure...
The non-coding epitranscriptome in cancer.
Post-synthesis modification of biomolecules is an efficient way of regulating and optimizing their functions. The human epitranscriptome includes a variety of more than 100 modifications known to exist in all RNA subtypes....
Integrating uncertainty into public energy research and development decisions
Public energy research and development (R&D) is recognized as a key policy tool for transforming the world’s energy system in a cost-effective way. However, managing the uncertainty surrounding technological change is a critical...
The Estrogen Receptor α Signaling Pathway Controls Alternative Splicing in the Absence of Ligands in Breast Cancer Cells.
BACKGROUND: The transcriptional activity of estrogen receptor α (ERα) in breast cancer (BC) is extensively characterized. Our group has previously shown that ERα controls the expression of a number of genes in its unliganded...
Multi-Temporal InSAR for transport infrastructure monitoring
Valentina Macchiarulo, Pietro Milillo, Chris Blenkinsopp, Cormac Reale, Giorgia Giardina
Jan 19, 2022
Worldwide, transport infrastructure is increasingly vulnerable to ageing-induced deterioration and climate-related hazards. Oftentimes inspection and maintenance costs far exceed available resources, and numerous assets lack any...
bridge evaluation deformation Monitoring safety and hazards settlement /dk/atira/pure/subjectarea/asjc/2200/2205 name=Civil and Structural Engineering /dk/atira/pure/subjectarea/asjc/2200/2215 name=Building and Construction /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
An Agent-Based Social Simulation for Citizenship Competences and Conflict Resolution Styles
The development of citizenship competences plays an important role in a complex system like society. Thus, to analyze how such competences impact other contexts is a great challenge because this kind of study involves the work...
Published by: IGI Global Scientific Publishing
Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells
Valentina Salvestrini, Marilena Ciciarello, Valentina Pensato, Giorgia Simonetti, Maria Antonella Laginestra, Samantha Bruno, Martina Pazzaglia, Elena De Marchi, Dorian Forte, Stefania Orecchioni, Giovanni Martinelli, Francesco Bertolini, Simon Méndez-Ferrer, Elena Adinolfi, Francesco Di Virgilio, Michele Cavo, Antonio Curti
Aug 07, 2020
The contribution of cell-extrinsic factors in Acute Myeloid Leukemia (AML) generation and persistence has gained interest. Bitter taste receptors (TAS2Rs) are G protein-coupled receptors known for their primary role as a central...
Denatonium as a Bitter Taste Receptor Agonist Modifies Transcriptomic Profile and Functions of Acute Myeloid Leukemia Cells
Valentina Salvestrini, Marilena Ciciarello, Valentina Pensato, Giorgia Simonetti, Maria Antonella Laginestra, Samantha Bruno, Martina Pazzaglia, Elena De Marchi, Dorian Forte, Stefania Orecchioni, Giovanni Martinelli, Francesco Bertolini, Simon Méndez-Ferrer, Elena Adinolfi, Francesco Di Virgilio, Michele Cavo, Antonio Curti
Apr 22, 2021
The contribution of cell-extrinsic factors in Acute Myeloid Leukemia (AML) generation and persistence has gained interest. Bitter taste receptors (TAS2Rs) are G protein-coupled receptors known for their primary role as a central...
The Estrogen Receptor α Signaling Pathway Controls Alternative Splicing in the Absence of Ligands in Breast Cancer Cells.
BACKGROUND: The transcriptional activity of estrogen receptor α (ERα) in breast cancer (BC) is extensively characterized. Our group has previously shown that ERα controls the expression of a number of genes in its unliganded...
Extrastriatal 123I-FP-CIT SPECT impairment in Parkinson's disease - the PPMI cohort.
BACKGROUND: Neuropathological data and nuclear medicine imaging show extensive serotonergic impairment in Parkinson's disease (PD). We undertook a case-controlled analysis of 123I-FP-CIT SPECT images to measure extrastriatal...
Dopamine Parkinson’s disease SPECT Serotonin Adult Aged Brain Case-Control Studies Cohort Studies Disease Progression Female Humans Image Interpretation Computer-Assisted Iodine Radioisotopes Male Middle Aged Parkinson Disease Serotonin Plasma Membrane Transport Proteins Tomography Emission-Computed Single-Photon Tropanes
Structural and functional brain networks of individual differences in trait anger and anger control
The ability to experience, use and eventually control anger is crucial to maintain well-being and build healthy relationships. Despite its relevance, the neural mechanisms behind individual differences in experiencing and...
Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice.
Valentina Sanghez, Cankut Cubuk, Patricia Sebastián-Leon, Stefania Carobbio, Joaquin Dopazo, Antonio Vidal-Puig, Alessandro Bartolomucci
Mar 15, 2016
Adipose Tissue IRS1 IRS2 Insulin Metabolic Syndrome obesity Adipose Tissue White Animals Diet High-Fat Dominance-Subordination Down-Regulation Glucose Insulin Insulin Resistance Liver Male Mice Mice Inbred C57BL Muscle Skeletal obesity Real-Time Polymerase Chain Reaction Signal Transduction Stress Psychological
Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration
Valerie Kuan, Alasdair Warwick, Aroon Hingorani, Adnan Tufail, Valentina Cipriani, Stephen Burgess, Reecha Sofat, International AMD Genomics Consortium (IAMDGC)
Nov 05, 2021
IMPORTANCE: Advanced age-related macular degeneration (AMD) is a leading cause of blindness in Western countries. Causal, modifiable risk factors need to be identified to develop preventive measures for advanced AMD. OBJECTIVE...
Structural and Functional Determinants of AC8 Trafficking, Targeting and Responsiveness in Lipid Raft Microdomains.
The fidelity of cAMP in controlling numerous cellular functions rests crucially on the precise organization of cAMP microdomains that are sustained by the scaffolding properties of adenylyl cyclase. Earlier studies suggested...
Adenylyl cyclase Caveolin Cholesterol Lipid rafts plasma membrane cAMP Adenylyl Cyclases Bacterial Proteins Brefeldin A Bridged Bicyclo Compounds Heterocyclic Caveolin 1 Cyclic AMP Cytoskeleton Gene Expression Genes Reporter Green Fluorescent Proteins Guanine Nucleotide Exchange Factors HEK293 Cells Humans Luminescent Proteins Membrane Microdomains Mutagenesis Site-Directed Protein Transport RNA Small Interfering Recombinant Fusion Proteins Thiazolidines beta-Cyclodextrins
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