Uncovering the universality of self-replication in protein aggregation and its link to disease.
Georg Meisl,
Catherine K Xu,
Jonathan D Taylor,
Thomas CT Michaels,
Aviad Levin,
Daniel Otzen,
David Klenerman,
Steve Matthews,
Sara Linse,
Maria Andreasen,
Tuomas PJ Knowles
Sep 12, 2022
Fibrillar protein aggregates are a hallmark of a range of human disorders, from prion diseases to dementias, but are also encountered in several functional contexts. Yet, the fundamental links between protein assembly mechanisms...