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Relating structure to evolution in class II viral membrane fusion proteins.
Yorgo Modis
Sep 08, 2020
Enveloped viruses must fuse their lipid membrane to a cellular membrane to deliver the viral genome into the cytoplasm for replication. Viral envelope proteins catalyze this critical membrane fusion event. They fall into at...
Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses.
The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of...
A novel membrane fusion protein family in Flaviviridae?
Enveloped viruses must fuse their lipid membrane to a cellular membrane to deliver their genome into the cytoplasm for replication. Viral envelope proteins catalyze this critical membrane fusion event. They fall into three...
Imaging and visualizing SARS-CoV-2 in a new era for structural biology.
The SARS-CoV-2 pandemic has had a global impact and has put scientific endeavour in the spotlight, perhaps more than any previous viral outbreak. Fortuitously, the pandemic came at a time when decades of research in multiple...
Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Double-stranded RNA (dsRNA) is a potent proinflammatory signature of viral infection. Long cytosolic dsRNA is recognized by MDA5. The cooperative assembly of MDA5 into helical filaments on dsRNA nucleates the assembly of a...
AGS ATPase Aicardi-Goutières syndrome RIG-I-like receptor RLR SF2 helicases SMS Singleton-Merten syndrome cryo-EM Cryoelectron Microscopy helical reconstruction innate immune pattern recognition nucleic acid sensing superfamily 2 helicases Adenosine Triphosphate Cryoelectron Microscopy HEK293 Cells Humans Hydrolysis Hydrophobic and Hydrophilic Interactions Interferon-Induced Helicase IFIH1 Interferon-beta Molecular Docking Simulation Mutation Nucleic Acid Conformation Protein Conformation RNA Double-Stranded Signal Transduction Structure-Activity Relationship
Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.
Guido A Stoll, Shun-Ichiro Oda, Zheng-Shan Chong, Minmin Yu, Stephen H McLaughlin, Yorgo Modis
Jun 19, 2019
Endogenous retrovirus epigenetic silencing transcriptional repressor transposable element ubiquitin E3 ligase Amino Acid Sequence Binding Sites Chromatin Chromatin Assembly and Disassembly Cloning Molecular Crystallography X-Ray Epigenesis Genetic Escherichia coli Gene Expression Gene Silencing Genetic Vectors Humans Models Molecular Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Multimerization Recombinant Proteins Repressor Proteins Retroelements Sequence Alignment Sequence Homology Amino Acid Transcription Genetic Tripartite Motif-Containing Protein 28
Imaging and visualizing SARS-CoV-2 in a new era for structural biology.
The SARS-CoV-2 pandemic has had a global impact and has put scientific endeavour in the spotlight, perhaps more than any previous viral outbreak. Fortuitously, the pandemic came at a time when decades of research in multiple...
Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5.
Most organisms rely on innate immune receptors to recognize conserved molecular structures from invading microbes. Two essential innate immune receptors, RIG-I and MDA5, detect viral double-stranded RNA in the cytoplasm. The...
Structure and functional mapping of the KRAB‐KAP1 repressor complex
Transposable elements are a genetic reservoir from which new genes and regulatory elements can emerge. However, expression of transposable elements can be pathogenic and is therefore tightly controlled. KRAB domain‐containing...
A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus
Monique Merchant, carlos Perez Mata, yangci Liu, haomin Zhai, Anna Protasio, Yorgo Modis
Jun 11, 2022
Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus...
MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling.
Ming-Shih Hwang, Jérôme Boulanger, Jonathan D Howe, Anna Albecka, Mathias Pasche, Leila Mureşan, Yorgo Modis
Feb 11, 2019
storm Cell Death innate immunity pathogen-associated molecular pattern Signal Transduction 3T3 Cells Adaptor Proteins Signal Transducing Animals Cell Death Cytosol FIBROBLASTS Interferon-Induced Helicase IFIH1 Interferon-beta Membrane Transport Proteins Mice Mice Knockout Microscopy Mitochondrial Membranes Mitochondrial Precursor Protein Import Complex Proteins Protein Domains RNA Double-Stranded Receptors Cell Surface Signal Transduction Single-Cell Analysis West Nile Fever
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