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Results: 27
Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.
Daniel B Rainbow, Xin Yang, Oliver Burren, Marcin L Pekalski, Deborah J Smyth, Marcus DR Klarqvist, Christopher J Penkett, Kim Brugger, Howard Martin, John A Todd, Chris Wallace, Linda S Wicker
Aug 18, 2015
Dissecting the regulatory microenvironment of a large animal model of non-Hodgkin lymphoma
Dammy Pinheiro, Yu-Mei Chang, Hannah Bryant, Balazs Szladovits, Tim Dalessandri, Lucy J Davison, Elizabeth Yallop, Emily Mills, Chiara Leo, Ana Lara, Anneliese Stell, Gerry Polton, Oliver A Garden
Aug 15, 2014
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.
Ricardo C Ferreira, Xaquin Castro Dopico, João J Oliveira, Daniel B Rainbow, Jennie H Yang, Dominik Trzupek, Sarah A Todd, Mhairi McNeill, Maristella Steri, Valeria Orrù, Edoardo Fiorillo, Daniel JM Crouch, Marcin L Pekalski, Francesco Cucca, Tim I Tree, Tim J Vyse, Linda S Wicker, John A Todd
Jan 03, 2020
In systemic lupus erythematosus (SLE), perturbed immunoregulation underpins a pathogenic imbalance between regulatory and effector CD4+ T-cell activity. However, to date, the characterization of the CD4+ regulatory T cell (Treg)...
FOXP3 PD-1 PTPN22 Arg620Trp Autoimmunity Immunotherapy regulatory T cells (tregs) systemic lupus erythematosus (SLE) type I interferon Adult Aged Aged 80 and over Alleles Autoimmunity Female Forkhead Transcription Factors Humans Interleukin-2 Lupus Erythematosus Systemic Male Middle Aged Programmed Cell Death 1 Receptor Protein Tyrosine Phosphatase Non-Receptor Type 22 risk T-Lymphocytes Regulatory Young Adult
A systems biology approach uncovers the core gene regulatory network governing iridophore fate choice from the neural crest.
Kleio Petratou, Tatiana Subkhankulova, James A Lister, Andrea Rocco, Hartmut Schwetlick, Robert N Kelsh
Dec 13, 2018
Multipotent neural crest (NC) progenitors generate an astonishing array of derivatives, including neuronal, skeletal components and pigment cells (chromatophores), but the molecular mechanisms allowing balanced selection of each...
Generation of Distal Airway Epithelium from Multipotent Human Foregut Stem Cells.
Nicholas RF Hannan, Fotios Sampaziotis, Charis-Patricia Segeritz, Neil A Hanley, Ludovic Vallier
May 21, 2015
Cell Differentiation Cell Line Cell- and Tissue-Based Therapy Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Endoderm Epithelium Fibroblast Growth Factor 10 Forkhead Transcription Factors GATA6 Transcription Factor Humans Induced Pluripotent Stem Cells Lung Nuclear Proteins Pulmonary Surfactant-Associated Protein C Respiratory Mucosa Thyroid Nuclear Factor 1 Transcription Factors
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function.
Sarah K Whiteside, Francis M Grant, David S Gyori, Alberto G Conti, Charlotte J Imianowski, Paula Kuo, Rabab Nasrallah, Firas Sadiyah, Sergio A Lira, Frank Tacke, Robert L Eil, Oliver T Burton, James Dooley, Adrian Liston, Klaus Okkenhaug, Jie Yang, Rahul Roychoudhuri
May 10, 2021
CD4+ regulatory T (Treg) cells, dependent upon the transcription factor Foxp3, contribute to tumour immunosuppression but are also required for immune homeostasis. There is interest in developing therapies that selectively...
CCR8 CD4+ T cells CD8+ T cells FOXP3 Treg Cancer Immunotherapy Adenocarcinoma Animals Colorectal Neoplasms Forkhead Transcription Factors Humans Immune Tolerance Lymphocytes Tumor-Infiltrating Melanoma Melanoma Experimental Mice Mice Inbred C57BL Mice Knockout Receptors CCR8 Skin Neoplasms T-Lymphocytes Regulatory
The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro.
Christopher M Gaunt, Daniel B Rainbow, Ruairi J Mackenzie, Lorna B Jarvis, Hani S Mousa, Nicholas Cunniffe, Zoya Georgieva, J William Brown, Alasdair J Coles, Joanne L Jones
Jul 19, 2021
T cells Th17 & Tregs cells Autoimmunity Multiple Sclerosis retinoid X receptor (RXR) retinoids Adult Alitretinoin Bexarotene CD4-Positive T-Lymphocytes Cells Cultured Clinical Trials as Topic Fatty Acids Unsaturated Female Forkhead Transcription Factors Humans Leukocytes Mononuclear lymphopoiesis Middle Aged remyelination Retinoid X Receptors T-Lymphocytes Regulatory Tetrahydronaphthalenes Th17 Cells
Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis.
Dominik Trzupek, Melanie Dunstan, Antony J Cutler, Mercede Lee, Leila Godfrey, Lorna Jarvis, Daniel B Rainbow, Dominik Aschenbrenner, Joanne L Jones, Holm H Uhlig, Linda S Wicker, John A Todd, Ricardo C Ferreira
Sep 09, 2020
BACKGROUND: Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing (scRNA-seq) and...
AbSeq C-C chemokine receptor type 9 (CCR9) CD4+ T cells CD80 CD86 Immunophenotyping multi-omics regulatory T cells (tregs) Single-cell RNA sequencing (scRNA-seq) Adolescent Adult B7-1 Antigen B7-2 Antigen Female Forkhead Transcription Factors Humans Male Proteome RNA RNA-seq Single-Cell Analysis T-Lymphocytes Regulatory Transcriptome
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
JR Grainger, KA Smith, JP Hewitson, HJ McSorley, Y Harcus, KJ Filbey, CAM Finney, EJD Greenwood, DP Knox, MS Wilson, Y Belkaid, AY Rudensky, RM Maizels
Sep 20, 2017
Animals Antigens Helminth Benzamides Cell Proliferation Chronic Disease Dioxoles Forkhead Transcription Factors Gene Expression Regulation host-parasite interactions Mice Mice Inbred BALB C Mice Transgenic Nematospiroides dubius Phosphorylation Protein Serine-Threonine Kinases Receptor Transforming Growth Factor-beta Type II Receptors Transforming Growth Factor beta Signal Transduction Smad2 Protein Smad3 Protein Strongylida Infections T-Lymphocytes Regulatory Th1 Cells Th2 Cells Transforming Growth Factor beta
Genotype-phenotype correlation in two Polish neonates with alveolar capillary dysplasia.
Zuzanna Kozłowska, Zuzanna Owsiańska, Joanna P Wroblewska, Apolonia Kałużna, Andrzej Marszałek, Yogen Singh, Bartłomiej Mroziński, Qian Liu, Justyna A Karolak, Paweł Stankiewicz, Gail Deutsch, Marta Szymankiewicz-Bręborowicz, Tomasz Szczapa
Jun 29, 2021
BACKGROUND: Alveolar capillary dysplasia (ACD) is a rare cause of severe pulmonary hypertension and respiratory failure in neonates. The onset of ACD is usually preceded by a short asymptomatic period. The condition is...
Inclusion and exclusion in the history of developmental biology.
Nick Hopwood
Mar 07, 2019
Scientific disciplines embody commitments to particular questions and approaches, scopes and audiences; they exclude as well as include. Developmental biology is no exception, and it is useful to reflect on what it has kept in...
British Society for Developmental Biology (BSDB) comparative History of embryology Reproductive biology and medicine Society for Developmental Biology (SDB) experimental and human embryology Animals Caenorhabditis elegans Caenorhabditis elegans Proteins developmental biology Forkhead Transcription Factors Mutation Phenotype Protein-Tyrosine Kinases RNA Interference
A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System.
Dan Ma, Bowei Wang, Malgorzata Zawadzka, Ginez Gonzalez, Zhaozong Wu, Bin Yu, Emma L Rawlins, Robin Jm Franklin, Chao Zhao
Nov 07, 2018
Deciphering the Immune Complexity in Esophageal Adenocarcinoma and Pre-Cancerous Lesions With Sequential Multiplex Immunohistochemistry and Sparse Subspace Clustering Approach.
Srinand Sundaram, Eun Na Kim, Georgina M Jones, Shamilene Sivagnanam, Monika Tripathi, Ahmad Miremadi, Massimiliano di Pietro, Lisa M Coussens, Rebecca C Fitzgerald, Young Hwan Chang, Lizhe Zhuang
Jun 07, 2022
Esophageal adenocarcinoma (EAC) develops from a chronic inflammatory environment across four stages: intestinal metaplasia, known as Barrett's esophagus, low- and high-grade dysplasia, and adenocarcinoma. Although the genomic...
Barrett’s esophagus Esophageal Adenocarcinoma immune complexity multiplex imaging sparse subspace clustering Adenocarcinoma Antigen-Antibody Complex Barrett Esophagus Cluster Analysis Ecosystem Esophageal Neoplasms Forkhead Transcription Factors Humans Immunohistochemistry Metaplasia Tumor Microenvironment
FOXM1 binds directly to non-consensus sequences in the human genome.
Deborah A Sanders, Michael V Gormally, Giovanni Marsico, Dario Beraldi, David Tannahill, Shankar Balasubramanian
Jun 24, 2015
Base Sequence Binding Sites Cell Line Chromatin Immunoprecipitation Consensus Sequence DNA Forkhead Box Protein M1 Forkhead Transcription Factors Gene Expression Regulation Genome Human HEK293 Cells HeLa Cells Humans Mutation Promoter Regions Genetic Protein Binding Protein Structure Tertiary Proteomics Sequence Analysis DNA
Foxg1 localizes to mitochondria and coordinates cell differentiation and bioenergetics.
Laura Pancrazi, Giulietta Di Benedetto, Laura Colombaioni, Grazia Della Sala, Giovanna Testa, Francesco Olimpico, Aurelio Reyes, Massimo Zeviani, Tullio Pozzan, Mario Costa
May 08, 2019
Forkhead box g1 (Foxg1) is a nuclear-cytosolic transcription factor essential for the forebrain development and involved in neurodevelopmental and cancer pathologies. Despite the importance of this protein, little is known about...
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
David Gyori, Ee Lyn Lim, Francis M Grant, Dominik Spensberger, Rahul Roychoudhuri, Stephen J Shuttleworth, Klaus Okkenhaug, Len R Stephens, Phillip T Hawkins
Aug 20, 2018
cancer immunotherapy immunology MACROPHAGES oncology T cells Aminopyridines Animals Cell Line Tumor Class I Phosphatidylinositol 3-Kinases Diphtheria Toxin Disease Models Animal Drug Resistance Neoplasm Female Forkhead Transcription Factors Gene Knockout Techniques Humans Lymphocyte Depletion MACROPHAGES Male Mice Mice Transgenic Neoplasms Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Primary Cell Culture Purines Pyrroles Quinazolinones Receptors Granulocyte-Macrophage Colony-Stimulating Factor T-Lymphocytes Regulatory Tumor Microenvironment
Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells.
Charles JM Bell, Yongliang Sun, Urszula M Nowak, Jan Clark, Sarah Howlett, Marcin L Pekalski, Xin Yang, Oliver Ast, Inja Waldhauer, Anne Freimoser-Grundschober, Ekkehard Moessner, Pablo Umana, Christian Klein, Ralf J Hosse, Linda S Wicker, Laurence B Peterson
Oct 16, 2014
Autoimmunity Cytokine therapy Graft versus host disease IL-2 fusion proteins Regulatory T cells Animals Biomarkers CTLA-4 Antigen Dose-Response Relationship Drug Eosinophilia Female Forkhead Transcription Factors Humans Interleukin-2 Interleukin-2 Receptor alpha Subunit Lymphocyte Count Macaca fascicularis Male Mice Mice Knockout Phenotype Phosphorylation Protein Binding Recombinant Fusion Proteins Recombinant Proteins STAT5 Transcription Factor Signal Transduction T-Lymphocyte Subsets T-Lymphocytes Regulatory
The PI3K p110δ regulates expression of CD38 on regulatory T cells.
The PI3K pathway has emerged as a key regulator of regulatory T cell (Treg) development and homeostasis and is required for full Treg-mediated suppression. To identify new genes involved in PI3K-dependent suppression, we...
ADP-ribosyl Cyclase 1 adenine Animals Cell Proliferation Class I Phosphatidylinositol 3-Kinases Forkhead Transcription Factors Gene Expression Profiling Gene Expression Regulation Genome Lymphocyte Subsets Mice Phosphatidylinositol 3-Kinases Quinazolines RNA Messenger T-Lymphocytes Regulatory Tretinoin
Immune modulation by Schistosoma mansoni antigens in NOD mice
Paola Zaccone, Oliver T Burton, Sarah Gibbs, Nigel Miller, Frances M Jones, David W Dunne, Anne Cooke
Oct 03, 2017
Adaptive Immunity Animals Antigens Helminth Cell Proliferation Cytokines Dendritic Cells Diabetes mellitus Type 1 Female Forkhead Transcription Factors host-parasite interactions Immunity Innate MACROPHAGES Mice Mice Inbred NOD Models Immunological Phenotype Schistosoma mansoni Schistosomiasis mansoni statistics Nonparametric T-Lymphocytes Regulatory Th2 Cells Transforming Growth Factor beta
Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.
Nicholas O Burton, Vivek K Dwivedi, Kirk B Burkhart, Rebecca EW Kaplan, L Ryan Baugh, H Robert Horvitz
Feb 11, 2019
Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C. elegans mediates its...
Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Cloning Molecular Embryo Nonmammalian Embryonic Development Forkhead Transcription Factors Gene Expression Regulation Developmental Insulin Lysophosphatidylcholines Mutagenesis Nerve Tissue Proteins Neurotransmitter Agents Osmotic Pressure RNA Messenger Receptor Insulin Receptors Cytoplasmic and Nuclear Sensory Receptor Cells Signal Transduction Starvation Stress Physiological Sulfotransferases
FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures.
Kah Keng Wong, Duncan M Gascoyne, Elizabeth J Soilleux, Linden Lyne, Hayley Spearman, Giovanna Roncador, Lars M Pedersen, Michael B Møller, Tina M Green, Alison H Banham
Dec 17, 2018
FOXP2 shares partially overlapping normal tissue expression and functionality with FOXP1; an established diffuse large B-cell lymphoma (DLBCL) oncogene and marker of poor prognosis. FOXP2 is expressed in the plasma cell...
FOXP2 diffuse large B-cell lymphoma survival Adult Aged Aged 80 and over Antibodies Monoclonal Murine-Derived Antineoplastic Combined Chemotherapy Protocols Cell Line Tumor cyclophosphamide Doxorubicin Female Forkhead Transcription Factors Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Ontology Humans Kaplan-Meier Estimate Lymphoma Large B-Cell Diffuse Male Middle Aged prednisone Protein Binding Repressor Proteins Signal Transduction Transcriptome Vincristine Young Adult
The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.
Zongling Ji, Hisham Mohammed, Aaron Webber, Jenna Ridsdale, Namshik Han, Jason S Carroll, Andrew D Sharrocks
Apr 23, 2019
There are numerous forkhead transcription factors in mammalian cells but we know little about the molecular functions of the majority of these. FOXK2 is a ubiquitously expressed family member suggesting an important function...
Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells.
Deborah A Sanders, Caryn S Ross-Innes, Dario Beraldi, Jason S Carroll, Shankar Balasubramanian
May 01, 2019
BACKGROUND: The forkhead transcription factor FOXM1 is a key regulator of the cell cycle. It is frequently over-expressed in cancer and is emerging as an important therapeutic target. In breast cancer FOXM1 expression is linked...
FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.
PJ Brown, KK Wong, SL Felce, L Lyne, H Spearman, EJ Soilleux, LM Pedersen, MB Møller, TM Green, DM Gascoyne, AH Banham
Dec 17, 2018
The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-cell lymphoma (DLBCL). Here microarray analysis of FOXP1-silenced DLBCL cell lines identified differential regulation of immune...
Adult Aged Aged 80 and over Antibodies Monoclonal Murine-Derived Antigens Differentiation B-Lymphocyte Antineoplastic Combined Chemotherapy Protocols B-Lymphocytes cyclophosphamide Doxorubicin Female Forkhead Transcription Factors Gene Expression Regulation Neoplastic Germinal Center HLA-DR alpha-Chains Histocompatibility Antigens Class II Humans Lymphocyte Activation Lymphoma Large B-Cell Diffuse Male Middle Aged Neoplasm Staging Nuclear Proteins prednisone RNA Small Interfering Repressor Proteins Rituximab Signal Transduction Survival Analysis Trans-Activators Vincristine
Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma
Ashley Weir, Eun-Young Kang, Nicola S Meagher, Gregg S Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S Anglesio, Matthias W Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H Brand, James D Brenton, Angela Brooks-Wilson, Michael E Carney, Julie M Cunningham, Kara L Cushing-Haugen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Luis Paz-Ares, Javier Gayarre, Blake C Gilks, Marcel Grube, Paul R Harnett, Holly R Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y Hernandez, Sabine Heublein, Yajue Huang, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J Kennedy, Felix KF Kommoss, Jennifer M Koziak, Bernhard Kraemer, Nhu D Le, Jaime Lesnock, Jenny Lester, Jan Lubiński, Janusz Menkiszak, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Robles-Díaz, Matthias Ruebner, Mitul Shah, Raghwa Sharma, Yurii B Shvetsov, Helen Steed, Aline Talhouk, Sarah E Taylor, Nadia Traficante, Robert A Vierkant, Chen Wang, Lynne R Wilkens, Stacey J Winham, Javier Benitez, Andrew Berchuck, David D Bowtell, Francisco J Candido Dos Reis, Linda S Cook, Anna DeFazio, AOCS Group, Jennifer A Doherty, Peter A Fasching, María J García, Ellen L Goode, Marc T Goodman, Jacek Gronwald, David G Huntsman, Beth Y Karlan, Stefan Kommoss, Francesmary Modugno, Joellen M Schildkraut, Hans-Peter Sinn, Annette Staebler, Linda E Kelemen, Caroline E Ford, Usha Menon, Paul DP Pharoah, Martin Köbel, Susan J Ramus
Jan 05, 2023
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