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An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans.
Mélanie Tanguy, Louise Véron, Przemyslaw Stempor, Julie Ahringer, Peter Sarkies, Eric A Miska
Apr 11, 2018
Across metazoans, innate immunity is vital in defending organisms against viral infection. In mammals, antiviral innate immunity is orchestrated by interferon signaling, activating the STAT transcription factors downstream of...
Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis.
Bernhard Strauss, Andrew Harrison, Paula Almeida Coelho, Keiko Yata, Magdalena Zernicka-Goetz, Jonathon Pines
May 02, 2018
There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is essential...
Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.
Semin Lee, Philippe Thebault, Luca Freschi, Sylvie Beaufils, Tom L Blundell, Christian R Landry, Victor M Bolanos-Garcia, Sabine Elowe
Mar 12, 2021
Kinetochore targeting of the mitotic kinases Bub1, BubR1, and Mps1 has been implicated in efficient execution of their functions in the spindle checkpoint, the self-monitoring system of the eukaryotic cell cycle that ensures...
Amino Acid Motifs Animals Cattle Cell Cycle Proteins Chromosomes Human Computational Biology Enzyme Stability evolution Molecular HeLa Cells Humans Hydrogen-Ion Concentration M Phase Cell Cycle Checkpoints Mice Models Molecular Protein Multimerization Protein Serine-Threonine Kinases Protein Structure Tertiary Protein Transport Protein-Tyrosine Kinases Rats
The DNA methylation landscape of the root-knot nematode-induced pseudo-organ, the gall, in Arabidopsis, is dynamic, contrasting over time, and critically important for successful parasitism.
Ana Cláudia Silva, Virginia Ruiz-Ferrer, Sebastian Y Müller, Clement Pellegrin, Patricia Abril-Urías, Ángela Martínez-Gómez, Almudena Gómez-Rojas, Eduardo Berenguer, Pilar S Testillano, Maria Fe Andrés, Carmen Fenoll, Sebastian Eves-van den Akker, Carolina Escobar
Sep 02, 2022
Root-knot nematodes (RKNs) induce giant cells (GCs) within galls which are characterized by large-scale gene repression at early stages. However, the epigenetic mechanism(s) underlying gene silencing is (are) still poorly...
Meloidogyne javanica Arabidopsis DNA methylation/epigenetics signatures galls Giant Cells siRNAs tomato transposons Animals Arabidopsis Protein-Tyrosine Kinases Gene Expression Regulation Plant DNA Methylation Plant Roots Proto-Oncogene Proteins Tylenchoidea Arabidopsis Proteins DNA (Cytosine-5-)-Methyltransferases
In Candida albicans, the Nim1 kinases Gin4 and Hsl1 negatively regulate pseudohypha formation and Gin4 also controls septin organization.
In the development of hyphal germ tubes of Candida albicans, a band of septin forms at the base of the germ tube (basal septin band). Later, a septin ring forms, which organizes the first septum within the germ tube (septin...
Candida albicans Cell Cycle Proteins Cell Division Cyclin-Dependent Kinases Cytoskeletal Proteins Fungal Proteins GTP Phosphohydrolases Humans Hyphae Phenotype Protein Serine-Threonine Kinases Protein-Tyrosine Kinases Recombinant Fusion Proteins Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins
Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization.
Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in a variety of tumor types, most notably in Anaplastic Large Cell Lymphoma (ALCL) where a chromosomal translocation generates the oncogenic...
Anaplastic Lymphoma Kinase Animals Cell Adhesion Cell Cycle Cell Proliferation Cell Transformation Neoplastic Cells Cultured Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Embryo Mammalian FIBROBLASTS Humans Mice Models Biological Mutation Protein Processing Post-Translational Protein Stability Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases Retinoblastoma Protein Transcription Genetic Tumor Suppressor Protein p53
Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
T cell Cell Signaling cluster of differentiation 4 (CD4) immunology non-receptor tyrosine kinase (nRTK) protein phosphorylation sterile α motif (SAM) Adaptor Proteins Signal Transducing Amino Acid Motifs Amino Acid Substitution Animals Humans Jurkat Cells Lymphocyte Activation Mice Mutation Missense Phosphoproteins Phosphorylation Protein Domains Protein-Tyrosine Kinases Receptors Antigen T-Cell T-Lymphocytes Tyrosine
Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates.
Remkes A Scheele, Laurens H Lindenburg, Maya Petek, Markus Schober, Kevin N Dalby, Florian Hollfelder
Mar 15, 2022
Catalysis Epistasis Genetic Humans MAP Kinase Kinase 1 MAP Kinase Signaling System Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinases Molecular Docking Simulation Phosphates Phosphorylation Protein Domains Protein Kinases Protein-Tyrosine Kinases Signal Transduction Substrate Specificity
IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma.
Nina Prokoph, Nicola A Probst, Liam C Lee, Jack M Monahan, Jamie D Matthews, Huan-Chang Liang, Klaas Bahnsen, Ivonne A Montes-Mojarro, Elif Karaca-Atabay, Geeta G Sharma, Vikas Malik, Hugo Larose, Sorcha D Forde, Stephen P Ducray, Cosimo Lobello, Qi Wang, Shi-Lu Luan, Šárka Pospíšilová, Carlo Gambacorti-Passerini, GA Amos Burke, Shahid Pervez, Andishe Attarbaschi, Andrea Janíková, Hélène Pacquement, Judith Landman-Parker, Anne Lambilliotte, Gudrun Schleiermacher, Wolfram Klapper, Ralf Jauch, Wilhelm Woessmann, Gilles Vassal, Lukas Kenner, Olaf Merkel, Luca Mologni, Roberto Chiarle, Laurence Brugières, Birgit Geoerger, Isaia Barbieri, Suzanne D Turner
May 26, 2020
Anaplastic large cell lymphoma (ALCL) is a T-cell malignancy predominantly driven by a hyperactive anaplastic lymphoma kinase (ALK) fusion protein. ALK inhibitors, such as crizotinib, provide alternatives to standard...
Antineoplastic Agents CRISPR-Cas Systems Cell Line Crizotinib Dose-Response Relationship Drug Drug Resistance Neoplasm Gene Editing Gene Expression Humans Immunohistochemistry Interleukin-10 Receptor alpha Subunit Lymphoma Large-Cell Anaplastic Models Biological Nucleophosmin Protein Kinase Inhibitors Protein-Tyrosine Kinases STAT3 Transcription Factor Signal Transduction
Tim IM Malcolm, Patrick Villarese, Camilla J Fairbairn, Laurence Lamant, Amélie Trinquand, C Elizabeth Hook, GA Amos Burke, Laurence Brugières, Katherine Hughes, Dominique Payet, Olaf Merkel, Ana-Iris Schiefer, Ibraheem Ashankyty, Shahid Mian, Mariusz Wasik, Martin Turner, Lukas Kenner, Vahid Asnafi, Elizabeth Macintyre, Suzanne D Turner
Oct 28, 2015
Adult Animals CD4 Antigens Cell Line Tumor Child Disease Models Animal Female Flow Cytometry Gene Rearrangement T-Lymphocyte Genes RAG-1 Genes T-Cell Receptor alpha Genes T-Cell Receptor beta Humans Immunohistochemistry Jurkat Cells Lymphoma Large-Cell Anaplastic Male Mice Mice Transgenic Protein-Tyrosine Kinases Receptor Notch1 Receptors Antigen T-Cell Receptors Antigen T-Cell alpha-beta Reverse Transcriptase Polymerase Chain Reaction Thymocytes Thymus Gland
Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.
Hugo Larose, Nina Prokoph, Jamie D Matthews, Michaela Schlederer, Sandra Högler, Ali F Alsulami, Stephen P Ducray, Edem Nuglozeh, Feroze MS Fazaludeen, Ahmed Elmouna, Monica Ceccon, Luca Mologni, Carlo Gambacorti-Passerini, Gerald Hoefler, Cosimo Lobello, Sarka Pospisilova, Andrea Janikova, Wilhelm Woessmann, Christine Damm-Welk, Martin Zimmermann, Alina Federova, Andrea Malone, Owen Smith, Mariusz Wasik, Giorgio Inghirami, Laurence Lamant, Tom L Blundell, Wolfram Klapper, Olaf Merkel, Amos GA Burke, Shahid Mian, Ibraheem Ashankyty, Lukas Kenner, Suzanne D Turner
Apr 06, 2020
Inclusion and exclusion in the history of developmental biology.
Nick Hopwood
Mar 07, 2019
Scientific disciplines embody commitments to particular questions and approaches, scopes and audiences; they exclude as well as include. Developmental biology is no exception, and it is useful to reflect on what it has kept in...
British Society for Developmental Biology (BSDB) comparative History of embryology Reproductive biology and medicine Society for Developmental Biology (SDB) experimental and human embryology Animals Caenorhabditis elegans Caenorhabditis elegans Proteins developmental biology Forkhead Transcription Factors Mutation Phenotype Protein-Tyrosine Kinases RNA Interference
Genome-wide meta-analysis identifies 3 novel loci associated with stroke.
Rainer Malik, Kristiina Rannikmäe, Matthew Traylor, Marios K Georgakis, Muralidharan Sargurupremraj, Hugh S Markus, Jemma C Hopewell, Stephanie Debette, Cathie LM Sudlow, Martin Dichgans, MEGASTROKE consortium and the International Stroke Genetics Consortium
Dec 21, 2018
We conducted a European-only and transancestral genome-wide association meta-analysis in 72,147 stroke patients and 823,869 controls using data from UK Biobank (UKB) and the MEGASTROKE consortium. We identified an exonic...
The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site.
Katrin de Graaf, Hanna Czajkowska, Sabine Rottmann, Len C Packman, Richard Lilischkis, Bernhard Lüscher, Walter Becker
Jun 13, 2011
Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency.
Monica Ceccon, Maria Elena Boggio Merlo, Luca Mologni, Teresa Poggio, Lydia M Varesio, Matteo Menotti, Silvia Bombelli, Roberta Rigolio, Andrea D Manazza, Filomena Di Giacomo, Chiara Ambrogio, Giovanni Giudici, Cesare Casati, Cristina Mastini, Mara Compagno, Suzanne D Turner, Carlo Gambacorti-Passerini, Roberto Chiarle, Claudia Voena
Jan 08, 2016
Animals Apoptosis Blotting Western Cell Line Tumor Cell Survival Cells Cultured Crizotinib Dose-Response Relationship Drug Drug Synergism Extracellular Signal-Regulated MAP Kinases Histones Humans Hydrazines Lymphoma Large-Cell Anaplastic Mice Inbred NOD Mice Knockout Mice SCID Microscopy Confocal Nucleophosmin Oncogene Proteins Fusion Protein Kinase Inhibitors Protein-Tyrosine Kinases Pyrazoles Pyridines RNA Interference Signal Transduction Transplantation Heterologous Triazoles
Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling.
Melanie R Hassler, Walter Pulverer, Ranjani Lakshminarasimhan, Elisa Redl, Julia Hacker, Gavin D Garland, Olaf Merkel, Ana-Iris Schiefer, Ingrid Simonitsch-Klupp, Lukas Kenner, Daniel J Weisenberger, Andreas Weinhaeusel, Suzanne D Turner, Gerda Egger
Oct 28, 2016
Current and emerging therapeutic approaches for T-cell acute lymphoblastic leukaemia.
leukaemia novel treatments Antineoplastic Agents Antineoplastic Agents Immunological Apoptosis Arabinonucleosides Bridged Bicyclo Compounds Heterocyclic Cyclin-Dependent Kinases Genetic Heterogeneity Humans Immunotherapy Immunotherapy Adoptive Janus Kinase Inhibitors Molecular Targeted Therapy Neoplasm Proteins Phosphoinositide-3 Kinase Inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Protein Kinase Inhibitors Protein-Tyrosine Kinases Receptor Notch1 Receptors Interleukin-7 Salvage therapy Signal Transduction Sulfonamides therapies Investigational Treatment Outcome
TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection.
Diego Peretti, Heather L Smith, Nicholas Verity, Ibrahim Humoud, Lis de Weerd, Dean P Swinden, Joseph Hayes, Giovanna R Mallucci
Feb 15, 2021
Increasing levels of the cold-shock protein, RNA-binding motif 3 (RBM3), either through cooling or by ectopic over-expression, prevents synapse and neuronal loss in mouse models of neurodegeneration. To exploit this process...
Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine.
Siang-Boon Koh, Yann Wallez, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Tashinga E Bapiro, Frances M Richards, Duncan I Jodrell
Jun 29, 2018
Combination of cytotoxic therapy with emerging DNA damage response inhibitors (DDRi) has been limited by tolerability issues. However, the goal of most combination trials has been to administer DDRi with standard-of-care doses...
Animals Antineoplastic Combined Chemotherapy Protocols Cell Cycle Proteins Cell Line Tumor Cell Proliferation Checkpoint Kinase 1 DNA Damage DNA Replication Deoxycytidine Drug Synergism Female Humans Mice Mice Inbred BALB C Mice Nude Nuclear Proteins Protein-Tyrosine Kinases Xenograft Model Antitumor Assays Gemcitabine
Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.
Nicole Prutsch, Elisabeth Gurnhofer, Tobias Suske, Huan Chang Liang, Michaela Schlederer, Simone Roos, Lawren C Wu, Ingrid Simonitsch-Klupp, Andrea Alvarez-Hernandez, Christoph Kornauth, Dario A Leone, Jasmin Svinka, Robert Eferl, Tanja Limberger, Astrid Aufinger, Nitesh Shirsath, Peter Wolf, Thomas Hielscher, Christina Sternberg, Fritz Aberger, Johannes Schmoellerl, Dagmar Stoiber, Birgit Strobl, Ulrich Jäger, Philipp B Staber, Florian Grebien, Richard Moriggl, Mathias Müller, Giorgio G Inghirami, Takaomi Sanda, A Thomas Look, Suzanne D Turner, Lukas Kenner, Olaf Merkel
Nov 06, 2018
TYK2 is a member of the JAK family of tyrosine kinases that is involved in chromosomal translocation-induced fusion proteins found in anaplastic large cell lymphomas (ALCL) that lack rearrangements activating the anaplastic...
Anaplastic Lymphoma Kinase Animals Apoptosis Cell Line Tumor Cell Survival Gene Expression Regulation Neoplastic Humans Lymphoma Large-Cell Anaplastic Mice Myeloid Cell Leukemia Sequence 1 Protein Phosphorylation Protein Kinase Inhibitors Protein-Tyrosine Kinases STAT1 Transcription Factor STAT3 Transcription Factor Signal Transduction TYK2 Kinase Translocation Genetic
DNA REPAIR. Drugging DNA repair.
Inhibiting DNA repair can have a positive outcome on therapeutic interventions
Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.
Patients with mutations in inducible T cell kinase (ITK) are susceptible to viral infections, particularly EBV, suggesting that these patients have defective function of CD8+ CTLs. In this study, we evaluated the effects of ITK...
An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei.
The sleeping sickness parasite, Trypanosoma brucei, uses quorum sensing (QS) to balance proliferation and transmission potential in the mammal bloodstream. A signal transduction cascade regulates this process, a component of...
DYRK Trypanosoma DIFFERENTIATION Gene Expression infectious disease microbiology None PARASITE Protein Kinase Amino Acid Motifs Cell Differentiation Gene Expression Regulation Developmental Protein Serine-Threonine Kinases Protein-Tyrosine Kinases Quorum Sensing Signal Transduction Transcription Genetic Trypanosoma brucei brucei