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Results: 52
How health system factors influence referral decisions in patients that may have cancer
Michael Harris, Peter Frey, Magdalena Esteva, Svjetlana Gasparovic Babic, Mercè Marzo-Castillejo, Davorina Petek, Marija Petek Ster, Hans Thulesius
Jan 01, 0001
Objective: To identify the system and other non-clinical factors that may influence a General Practitioners’ decision on whether to refer a patient who may have cancer. Study design: Expert group discussion and consensus...
How health system factors influence referral decisions in patients that may have cancer
Michael Harris, Peter Frey, Magdalena Esteva, Svjetlana Gasparovic Babic, Mercè Marzo-Castillejo, Davorina Petek, Marija Petek Ster, Hans Thulesius
Jan 01, 0001
Objective: To identify the system and other non-clinical factors that may influence a General Practitioners’ decision on whether to refer a patient who may have cancer. Study design: Expert group discussion and consensus...
Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis
Stephane Emond, Maya Petek, Emily J. Kay, Brennen Heames, Sean R. A. Devenish, Nobuhiko Tokuriki, Florian Hollfelder
Jul 10, 2020
Abstract: Insertions and deletions (InDels) are frequently observed in natural protein evolution, yet their potential remains untapped in laboratory evolution. Here we introduce a transposon-based mutagenesis approach (TRIAD) to...
Accessing unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis
Stephane Emond, Maya Petek, Emily J. Kay, Brennen Heames, Sean R. A. Devenish, Nobuhiko Tokuriki, Florian Hollfelder
Jul 28, 2021
Abstract: Insertions and deletions (InDels) are frequently observed in natural protein evolution, yet their potential remains untapped in laboratory evolution. Here we introduce a transposon-based mutagenesis approach (TRIAD) to...
Historical Ecologies of Pastoralist Overgrazing in Kenya
Abstract: The spectre of ‘overgrazing’ looms large in historical and political narratives of ecological degradation in savannah ecosystems. While pastoral exploitation is a conspicuous driver of landscape variability and...
Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation.
Sports Tourism Products
In addition to good accommodation and sports infrastructure, Slovenia has an extremely developed system of training, testing, and rehabilitation of athletes. Slovenian athletes have always topped in various sports providing...
Published by: IGI Global Scientific Publishing
Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates.
Remkes A Scheele, Laurens H Lindenburg, Maya Petek, Markus Schober, Kevin N Dalby, Florian Hollfelder
Mar 15, 2022
Catalysis Epistasis Genetic Humans MAP Kinase Kinase 1 MAP Kinase Signaling System Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinases Molecular Docking Simulation Phosphates Phosphorylation Protein Domains Protein Kinases Protein-Tyrosine Kinases Signal Transduction Substrate Specificity
A C. elegans model for neurodegeneration in Cockayne syndrome.
Amanda FC Lopes, Katarzyna Bozek, Marija Herholz, Aleksandra Trifunovic, Matthias Rieckher, Björn Schumacher
Nov 24, 2020
Cockayne syndrome (CS) is a congenital syndrome characterized by growth and mental retardation, and premature ageing. The complexity of CS and mammalian models warrants simpler metazoan models that display CS-like phenotypes...
Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates
Abstract The combination of ultrahigh-throughput screening and sequencing informs on function and intragenic epistasis within combinatorial protein mutant libraries. Establishing a droplet-based...
Remkes A Scheele, Laurens H Lindenburg, Maya Petek, Markus Schober, Kevin N Dalby, Florian Hollfelder
Feb 11, 2022
The route of administration, timing, duration and dose of postmenopausal hormone therapy and cardiovascular outcomes in women
Clare Oliver-Williams, Marija Glisic, Sara Shahzad, Elizabeth Brown, Cristina Pellegrino Baena, Mahmuda Chadni, Rajiv Chowdhury, Oscar H Franco, Taulant Muka
Dec 19, 2018
cardiovascular risk coronary heart disease hormone therapy Menopause Myocardial Infarction stroke venous thromboembolism Cardiovascular Diseases Estradiol Estrogen Replacement Therapy Estrogens Female Humans Menopause Middle Aged Postmenopause Progesterone Prospective Studies stroke Thrombosis venous thromboembolism
Hidden Specificities in Enzyme Catalysis
Matthias Häckh, Xavier Lucas, Marija Marolt, Peter F Leadlay, Michael Müller, Stefan Günther, Steffen Lüdeke
Feb 12, 2019
Enzymes often convert both physiological and non-physiological substrates with high stereoselectivity; yet, for some enzymes, opposite product chirality is observed. A possible explanation is the existence of hidden...
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Marija Iljina, Laura Tosatto, Minee L Choi, Jason C Sang, Yu Ye, Craig D Hughes, Clare E Bryant, Sonia Gandhi, David Klenerman
Dec 04, 2017
A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer
Association between progestin-only contraceptive use and cardiometabolic outcomes
Marija Glisic, Sara Shahzad, Stergiani Tsoli, Mahmuda Chadni, Eralda Asllanaj, Lyda Z Rojas, Elizabeth Brown, Rajiv Chowdhury, Taulant Muka, Oscar H Franco
Dec 07, 2018
Aims The association between progestin-only contraceptive (POC) use and the risk of various cardiometabolic outcomes has rarely been studied. We performed a systematic review and meta-analysis to determine the impact of POC use...
Progestogen cardiometabolic risk Contraception Hypertension Myocardial Infarction Progesterone progestin-only pill stroke Type 2 diabetes venous thromboembolism women Administration Oral Adolescent Adult Aged Cardiovascular Diseases Contraceptives Oral Hormonal Diabetes mellitus Drug Implants Female Humans Injections Middle Aged Progestins Risk Assessment Risk Factors Venous Thromboembolism Young Adult
Quantifying Co-Oligomer Formation by α-Synuclein.
Marija Iljina, Alexander J Dear, Gonzalo A Garcia, Suman De, Laura Tosatto, Patrick Flagmeier, Daniel R Whiten, Thomas CT Michaels, Daan Frenkel, Christopher M Dobson, Tuomas PJ Knowles, David Klenerman
Dec 07, 2018
A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer
Silvana Debernardi, Harrison O'Brien, Asma S Algahmdi, Nuria Malats, Grant D Stewart, Marija Plješa-Ercegovac, Eithne Costello, William Greenhalf, Amina Saad, Rhiannon Roberts, Alexander Ney, Stephen P Pereira, Hemant M Kocher, Stephen Duffy, Oleg Blyuss, Tatjana Crnogorac-Jurcevic
Nov 23, 2020
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with around 9% of patients surviving >5 years. Asymptomatic in its initial stages, PDAC is mostly diagnosed late, when already a locally...
Adult Aged Aged 80 and over Antigens Tumor-Associated Carbohydrate Biomarkers Tumor Carcinoma Pancreatic Ductal Early Detection of Cancer Europe Female Humans Lithostathine Male Middle Aged Pancreatic Neoplasms Predictive Value of Tests Reproducibility of Results Retrospective Studies Trefoil Factor-1 Urinalysis Vesicular Transport Proteins Young Adult
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A. Lazarus, Mona Shehata, Bruno M. Simões, Alice R. Greenhalgh, Sacha J. Howell, Robert B. Clarke, Carlos Caldas, Timotheus Y. F. Halim, John C. Marioni, Walid T. Khaled
Mar 09, 2021
Abstract: It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little...
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
Mathew H Horrocks, Steven F Lee, Sonia Gandhi, Nadia K Magdalinou, Serene W Chen, Michael J Devine, Laura Tosatto, Magnus Kjaergaard, Joseph S Beckwith, Henrik Zetterberg, Marija Iljina, Nunilo Cremades, Christopher M Dobson, Nicholas W Wood, David Klenerman
Jan 26, 2016
Guidelines for the functional annotation of microRNAs using the Gene Ontology.
Rachael P Huntley, Dmitry Sitnikov, Marija Orlic-Milacic, Rama Balakrishnan, Peter D'Eustachio, Marc E Gillespie, Doug Howe, Anastasia Z Kalea, Lars Maegdefessel, David Osumi-Sutherland, Victoria Petri, Jennifer R Smith, Kimberly Van Auken, Valerie Wood, Anna Zampetaki, Manuel Mayr, Ruth C Lovering
Jan 22, 2016
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
The Expansion of Approximant /r/ in Dutch
Renée Van Bezooijen
Sep 30, 2014
In present-day Standard Dutch as spoken in the Netherlands, three main categories of pronunciation variants of Irl can be distinguished, namely alveolar /r/, uvular /r/, and approximant /r/. Approximant /r/, the focus of this...
Published by: Atlantic Provinces Linguistic Association
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