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Comparing oncology clinical programs by use of innovative designs and expected net present value optimization
Tom Parke, Olga Marchenko, Vladimir Anisimov, Anastasia Ivanova, Christopher Jennison, Inna Perevozskaya, Guochen Song
Jan 01, 0001
Designing an oncology clinical program is more challenging than designing a single study. The standard approaches have been proven to be not very successful during the last decade; the failure rate of Phase 2 and Phase 3...
Comparing oncology clinical programs by use of innovative designs and expected net present value optimization
Tom Parke, Olga Marchenko, Vladimir Anisimov, Anastasia Ivanova, Christopher Jennison, Inna Perevozskaya, Guochen Song
Jan 01, 0001
Designing an oncology clinical program is more challenging than designing a single study. The standard approaches have been proven to be not very successful during the last decade; the failure rate of Phase 2 and Phase 3...
Entrepreneurial innovative network and the design of socio-economic neural system
Olga Tikhomirova
Apr 01, 2020
This article aims to establish how an idea becomes an innovation and how creativity, collective dynamics, and information are interconnected. The results of the study showed that the emergence of innovations is closely connected...
Published by: IGI Global Scientific Publishing
Mobile Learning to Support Self-Regulated Learning
This paper discusses the possibilities of using and designing mobile technology for learning purposes coupled with learning analytics to support self-regulated learning (SRL). Being able to self-regulate one's own learning is...
Published by: IGI Global Scientific Publishing
Affective Support for Self-Regulation in Mobile-Assisted Language Learning
Mobile-assisted language learning (MALL) research includes examination and development of second language learners' cognitive and metacognitive self-regulated learning skills, but the affective learning component of...
Published by: IGI Global Scientific Publishing
Smartization in Gatchina
In the paper, a case of a Russian town, Gatchina, is examined to find the reasonable balance between international smart city practice, governmental requirements, historical identity preservation, and human-oriented approach....
Published by: IGI Global Scientific Publishing
A one-year study of human milk oligosaccharide profiles in the milk of healthy UK mothers and their relationship to maternal FUT2 genotype.
Sierra D Durham, Randall C Robinson, Laurentya Olga, Ken K Ong, Maciej Chichlowski, David B Dunger, Daniela Barile
Jun 28, 2021
Human milk oligosaccharides (HMOs) are indigestible carbohydrates with prebiotic, pathogen decoy and immunomodulatory activities that are theorized to substantially impact infant health. The objective of this study was to...
A Cyber Sensor Model for Cyber-Physical-Social Systems
Engineering sustainable cyber-physical-social systems demand a transdisciplinary approach. Within an arbitrary domain, many systems, including those of the physical and cyber categories, may already be in-situ; however...
Published by: IGI Global Scientific Publishing
Obtaining the Dynamic Coefficients of Structuredness for Assessing a Domain
Today, effective management of information requires an in-depth study of its internal organization. The structural organization of information affects the efficiency of choosing a method for solving the problem and the...
Published by: IGI Global Scientific Publishing
Butyrate in Human Milk
Laurentya Olga, Janna A van Diepen, Maciej Chichlowski, Clive J Petry, Jacques Vervoort, David B Dunger, Guus AM Kortman, Gabriele Gross, Ken K Ong
Mar 06, 2023
Early weight gain influences duration of breast feeding
OBJECTIVE: While several studies have shown that milk formula feeding is associated with faster infant weight gain compared with exclusively breast feeding (EBF), we explored the possible reverse association that infant weight...
Butyrate in Human Milk
Laurentya Olga, Janna A van Diepen, Maciej Chichlowski, Clive J Petry, Jacques Vervoort, David B Dunger, Guus A M Kortman, Gabriele Gross, Ken K Ong
Mar 28, 2023
Butyrate in human milk (HM) has been suggested to reduce excessive weight and adipo-sity gains during infancy. However, HM butyrate's origins, determinants, and its influencing mechanism on weight gain are not completely...
Infant growth infant weight gain infant adiposity human milk microbiota human milk butyrate human milk intake volume butyrate intake Milk Human Humans Weight Gain Butyrates Prospective Studies Breast Feeding Infant Female Microbiota
Published by: Nutrients
Discipline and Discretionary Power in Policing Homosexuality in Late Imperial St. Petersburg.
Olga Petri
Jun 01, 2018
This article explores queer sexual policing in late Imperial St. Petersburg (c.1900-1917). The focus is on the street-level constables who bore the principal responsibility for policing male homosexual offenses in the city's...
Health Technology Assessment and Health Care Reimbursement in the European Union
Olga Löblová
Jun 15, 2020
Member states have consistently limited the European Union's competences in the area of health care reimbursement. Despite these efforts, there has been a slow but steady tendency toward harmonization of a key tool in...
What has health technology assessment ever done for us?
Olga Löblová
Feb 13, 2018
Health technology assessment (HTA) has over the past three decades become a well-established part of decisions about allocation of resources in many countries. Despite this, little is known about HTA's impact on health systems....
Who's afraid of institutionalizing health technology assessment (HTA)?
Olga Löblová
Feb 13, 2018
This article identifies the interests and policy positions of key health policy stakeholders regarding the creation of a health technology assessment (HTA) agency in the Czech Republic, and what considerations influenced them....
Florigen and its homologs of FT/CETS/PEBP/RKIP/YbhB family may be the enzymes of small molecule metabolism
BACKGROUND: Flowering signals are sensed in plant leaves and transmitted to the shoot apical meristems, where the formation of flowers is initiated. Searches for a diffusible hormone-like signaling entity ("florigen") went on...
Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism.
Samuel Furse, Stuart G Snowden, Laurentya Olga, Philippa Prentice, Ken K Ong, Ieuan A Hughes, Carlo L Acerini, David B Dunger, Albert Koulman
Sep 18, 2019
We tested the hypothesis that both postnatal feeding and conditions in utero affect lipid metabolism in infants. Infants who experienced restrictive growth conditions in utero and others exposed to maternal hyperglycaemia were...
Bottle Feeding Breast Feeding Child Development Diabetes Gestational Female Glycerides Humans Infant Infant Formula Infant Nutritional Physiological Phenomena Infant Newborn Infant Small for Gestational Age Lipid Metabolism Male Phospholipids Pilot Projects Postpartum Period Pregnancy prenatal exposure delayed effects Prospective Studies Sterols
Reduced size at birth and persisting reductions in adiposity in recent, compared with earlier, cohorts of infants born to mothers with gestational diabetes mellitus.
Philippa M Prentice, Laurentya Olga, Clive J Petry, David Simmons, Helen R Murphy, Ieuan A Hughes, Carlo L Acerini, Ken K Ong, David B Dunger
Jul 04, 2019
Adiposity Gestational diabetes mellitus growth Infancy Macrosomia Maternal hyperglycaemia Offspring Skinfold Thickness Weight Gain Adiposity Adult Anthropometry Birth Weight Body Size Child Preschool Diabetes Gestational Female Fetal Macrosomia Glucose Tolerance Test Humans Infant Infant Newborn Life Style Male Maternal Age obesity Phenotype Pregnancy Prospective Studies Retrospective Studies
The grasshopper problem.
We introduce and physically motivate the following problem in geometric combinatorics, originally inspired by analysing Bell inequalities. A grasshopper lands at a random point on a planar lawn of area 1. It then jumps once, a...
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